Confidence intervals for the difference in paired Youden indices

Comparison of accuracy between two diagnostic tests can be implemented by investigating the difference in paired Youden indices. However, few literature articles have discussed the inferences for the difference in paired Youden indices. In this paper, we propose an exact confidence interval for the difference in paired Youden indices based on the generalized pivotal quantities. For comparison, the maximum likelihood estimate‐based interval and a bootstrap‐based interval are also included in the study for the difference in paired Youden indices. Abundant simulation studies are conducted to compare the relative performance of these intervals by evaluating the coverage probability and average interval length. Our simulation results demonstrate that the exact confidence interval outperforms the other two intervals even with small sample size when the underlying distributions are normal. A real application is also used to illustrate the proposed intervals. Copyright © 2012 John Wiley & Sons, Ltd.     

The Appropriateness of Some Common Procedures for Testing the Equality of Two Independent Binomial Populations

For testing the equality of two independent binomial populations the Fisher exact test and the chi-squared test with Yates's continuity correction are often suggested for small and intermediate size samples. The use of these tests is inappropriate in that they are extremely conservative. In this article we demonstrate that, even for small samples, the uncorrected chi-squared test (i.e., the Pearson chi-squared test) and the two-independent-sample t test are robust in that their actual significance levels are usually close to or smaller than the nominal levels. We encourage the use of these latter two tests.     

New approximate confidence intervals for the difference between two Poisson means and comparison

The problem of estimating the difference between two Poisson means is considered. A new moment confidence interval (CI), and a fiducial CI for the difference between the means are proposed. The moment CI is simple to compute, and it specializes to the classical Wald CI when the sample sizes are equal. Numerical studies indicate that the moment CI offers improvement over the Wald CI when the sample sizes are different. Exact properties of the CIs based on the moment, fiducial and hybrid methods are evaluated numerically. Our numerical study indicates that the hybrid and fiducial CIs are in general comparable, and the moment CI seems to be the best when the expected total counts from both distributions are two or more. The interval estimation procedures are illustrated using two examples.     

Exact distribution of the MLEs of the parameters and of the quantiles of two-parameter exponential distribution under hybrid censoring

Epstein [Truncated life tests in the exponential case, Ann. Math. Statist. 25 (1954), pp. 555–564] introduced a hybrid censoring scheme (called Type-I hybrid censoring) and Chen and Bhattacharyya [Exact confidence bounds for an exponential parameter under hybrid censoring, Comm. Statist. Theory Methods 17 (1988), pp. 1857–1870] derived the exact distribution of the maximum-likelihood estimator (MLE) of the mean of a scaled exponential distribution based on a Type-I hybrid censored sample. Childs et al. [Exact likelihood inference based on Type-I and Type-II hybrid censored samples from the exponential distribution, Ann. Inst. Statist. Math. 55 (2003), pp. 319–330] provided an alternate simpler expression for this distribution, and also developed analogous results for another hybrid censoring scheme (called Type-II hybrid censoring). The purpose of this paper is to derive the exact bivariate distribution of the MLE of the parameter vector of a two-parameter exponential model based on hybrid censored samples. The marginal distributions are derived and exact confidence bounds for the parameters are obtained. The results are also used to derive the exact distribution of the MLE of the pth quantile, as well as the corresponding confidence bounds. These exact confidence intervals are then compared with parametric bootstrap confidence intervals in terms of coverage probabilities. Finally, we present some numerical examples to illustrate the methods of inference developed here.     

Bayes designs for multiple linear regression on the unit sphere

We deal with experimental designs minimizing the mean square error of the linear BAYES estimator for the parameter vector of a multiple linear regression model where the experimental region is the k-dimensional unit sphere. After computing the uniquely determined optimum information matrix, we construct, separately for the homogeneous and the inhomogeneous model, both approximate and exact designs having such an information matrix.     

A more powerful unconditional exact test of homogeneity for 2 × c contingency table analysis

The classical unconditional exact p-value test can be used to compare two multinomial distributions with small samples. This general hypothesis requires parameter estimation under the null which makes the test severely conservative. Similar property has been observed for Fisher's exact test with Barnard and Boschloo providing distinct adjustments that produce more powerful testing approaches. In this study, we develop a novel adjustment for the conservativeness of the unconditional multinomial exact p-value test that produces nominal type I error rate and increased power in comparison to all alternative approaches. We used a large simulation study to empirically estimate the 5th percentiles of the distributions of the p-values of the exact test over a range of scenarios and implemented a regression model to predict the values for two-sample multinomial settings. Our results show that the new test is uniformly more powerful than Fisher's, Barnard's, and Boschloo's tests with gains in power as large as several hundred percent in certain scenarios. Lastly, we provide a real-life data example where the unadjusted unconditional exact test wrongly fails to reject the null hypothesis and the corrected unconditional exact test rejects the null appropriately.     

Asymptotic Minimax Risk for the White Noise Model on the Sphere

Estimation of an unknown function on the unit sphere of the Euclidean space is considered. The function is observed in Gaussian continuous time white noise. Uniform norm is chosen as a loss function and exact asymptotic minimax risk is derived extending the result of Korostelev (1993). The exact asymptotic minimax risk is also given for the L ₂-loss, applying the result of Pinsker (1980).