Dependency and truncated forms of combinations in multivariate combination-based permutation tests and ordered categorical variables

ABSTRACT

Quite an important problem usually occurs in several multi-dimensional hypotheses testing problems when variables are correlated. In this framework the non-parametric combination (NPC) of a finite number of dependent permutation tests is suitable to cover almost all real situations of practical interest since the dependence relations among partial tests are implicitly captured by the combining procedure itself without the need to specify them [Pesarin F, Salmaso L. Permutation tests for complex data: theory, applications and software. Chichester: Wiley; 2010a]. An open problem related to NPC-based tests is the impact of the dependency structure on combined tests, especially in the presence of categorical variables. This paper’s goal is firstly to investigate the impact of the dependency structure on the possible significance of combined tests in cases of ordered categorical responses using Monte Carlo simulations, then to propose some specific procedures aimed at improving the power of multivariate combination-based permutation tests. The results show that an increasing level of correlation/association among responses negatively affects the power of combination-based multivariate permutation tests. The application of special forms of combination functions based on the truncated product method [Zaykin DV, Zhivotovsky LA, Westfall PH, Weir BS. Truncated product method for combining p-values. Genet Epidemiol. 2002;22:170–185; Dudbridge F, Koeleman BPC. Rank truncated product of p-values, with application to genomewide association scans. Genet Epidemiol. 2003;25:360–366] or on Liptak combination allowed us, using Monte Carlo simulations, to demonstrate the possibility of mitigating the negative effect on power of combination-based multivariate permutation tests produced by an increasing level of correlation/association among responses.     

Effect of tuberculosis on immune restoration among HIV-infected patients receiving antiretroviral therapy

In this article, time to immune recovery during antiretroviral therapy was estimated and compared between HIV-infected children with and without tuberculosis (TB). CD4?T-cell restoration was used as a criterion for determining immune recovery. The median residual lifetime function, which is more intuitive and robust compared to the frequently used measures of lifetime data, was used to estimate time to CD4?T-cell restoration. The median residual lifetime is not influenced by extreme observations and heavy-tailed distributions which are commonly encountered in clinical studies. Permutation-based methods were used to compare the CD4?T-cell restoration times between the two groups of patients. Our results indicate that children with TB had uniformly higher median residual lifetimes to immune recovery compared to those without TB. Although TB was associated with slower CD4?T-cell restoration, the differences between the restoration times of the two groups were not statistically significant.     

New innovational outlier unit root test with a break at an unknown time

The Perron test which is based on a Dickey–Fuller test regression is a commonly employed approach to test for a unit root in the presence of a structural break of unknown timing. In the case of an innovational outlier (IO), the Perron test tends to exhibit spurious rejections in finite samples when the break occurs under the null hypothesis. In the present paper, a new Perron-type IO unit root test is developed. It is shown in Monte Carlo experiments that the new test does not over-reject the null hypothesis. Even for the case of a level and slope break for trending data, the empirical size is near its nominal level. The test distribution equals the case of a known break date. Furthermore, the test is able to identify the true break date very accurately even for small breaks. As an application serves the Nelson–Plosser data set.     

Unconditional analogues of Cochran–Mantel–Haenszel tests

The Cochran–Mantel–Haenszel tests are a suite of tests that are usually defined as conditional tests, tests that assume all marginal totals are known before sighting the data. Here unconditional analogues of these tests are defined for the more usual situation when the marginal totals are not known before sighting the data.     

A comparison of some conditional and unconditional exact tests for 2x2 contingency tables

In 1935, R.A. Fisher published his well-known “exact” test for 2x2 contingency tables. This test is based on the conditional distribution of a cell entry when the rows and columns marginal totals are held fixed. Tocher (1950) and Lehmann (1959) showed that Fisher s test, when supplemented by randomization, is uniformly most powerful among all the unbiased tests UMPU). However, since all the practical tests for 2x2 tables are nonrandomized - and therefore biased the UMPU test is not necessarily more powerful than other tests of the same or lower size. Inthis work, the two-sided Fisher exact test and the UMPU test are compared with six nonrandomized unconditional exact tests with respect to their power. In both the two-binomial and double dichotomy models, the UMPU test is often less powerful than some of the unconditional tests of the same (or even lower) size. Thus, the assertion that the Tocher-Lehmann modification of Fisher's conditional test is the optimal test for 2x2 tables is unjustified.     

The measurement of capital utilisation rates

A strategy using spline function interpolation is developed f o r estimating capital utilisation rates . Cobb-Douglas, CES and translog functional forms are used in estimation. Tests for functional forms are conducted leading t o t h e s e l e c t i o n of the Cobb-Douglas form. Quarterly series of estimated utilisation rates and excess capacity measures are presented.     

The Effects of Detrending in Granger Causality Tests

Nonstationary time series are frequently detrended in empirical investigations by regressing the series on time or a function of time. The effects of the detrending on the tests for causal relationships in the sense of Granger are investigated using quarterly U.S. data. The causal relationships between nominal or real GNP and M1, inferred from the Granger–Sims tests, are shown to depend very much on, among other factors, whether or not series are detrended. Detrending tends to remove or weaken causal relationships, and conversely, failure to detrend tends to introduce or enhance causal relationships. The study suggests that we need a more robust test or a better definition of causality.     

NONPARAMETRIC TWO SAMPLE TESTS BASED ON AREA STATISTICS

ABSTRACT

Area statistics are sample versions of areas occurring in a probability plot of two distribution functions F and G. This paper presents a unified basis for five statistics of this type. They can be used for various testing problems in the framework of the two sample problem for independent observations, such as testing equality of distributions against inequality or testing stochastic dominance of distributions in one or either direction against nondominance. Though three of the statistics considered have already been suggested in literature, two of them are new and deserve our interest. The finite sample distributions of the statistics (under F=G) can be calculated via recursion formulae. Two tables with critical values of the new statistics are included. The asymptotic distribution of the properly normalized versions of the area statistics are functionals of the Brownian bridge. The distribution functions and quantiles thereof are obtained by Monte Carlo simulation. Finally, the power functions of the two new tests based on area statistics are compared to the power functions of the tests based on the corresponding supremum statistics, i.e., statistics of the Kolmogorov–Smirnov type.     

Psychologically and biochemically assessed stress in a follow-up study of long-term unemployed

Abstract

It has been suggested that psychological stress is one of the reasons for the high morbidity among unemployed people in Western countries. The same may apply to the well-documented high mortality. It would be expected that increased levels of biological stress would be found in these people. In the present study a sample of 310 long-term unemployed people from Norway was followed for 2 years. Psychologcal stress was assessed by medical examination and by the psychometric tests GHQ-28 and HSCL-30, the latter compared with a reference population of employed people. Serum levels of cortisol, prolactin and testosterone, together with immunoglobulins IgA, IgG and IgM, were compared with working controls. The unemployed had a high level of psychological distress at the first examination, the sanie for men and women. At the 2-year follow up distress was reduced by re-employment. This fits the ‘causation hypothesis' which explains the high distress level as caused by unemployment. The other direction of causation, ‘the selection hypothesis', assuming that distressed persons have an increased chance of continuous unemployment, was also confirmed in the present study. As for biological stress, significant differences were not found between the unemployment, the re-employed and the working controls.     

Bayesian Analysis of Contingency Tables

ABSTRACT

The display of the data by means of contingency tables is used in different approaches to statistical inference, for example, to broach the test of homogeneity of independent multinomial distributions. We develop a Bayesian procedure to test simple null hypotheses versus bilateral alternatives in contingency tables. Given independent samples of two binomial distributions and taking a mixed prior distribution, we calculate the posterior probability that the proportion of successes in the first population is the same as in the second. This posterior probability is compared with the p-value of the classical method, obtaining a reconciliation between both results, classical and Bayesian. The obtained results are generalized for r × s tables.