Pairwise comparisons of treatments with ordinal responses in a two-way setting

In clinical studies, pairwise comparisons are frequently performed to examine differences in efficacy between treatments. The statistical methods of pairwise comparisons are available when treatment responses are measured on an ordinal scale. The Wilcoxon–Mann–Whitney test and the latent normal model are popular examples. However, these procedures cannot be used to compare treatments in parallel groups (a two-way design) when overall type I error must be controlled. In this paper, we explore statistical approaches to the pairwise testing of treatments that satisfy the requirements of a two-way layout. The results of our simulation indicate that the latent normal approach is superior to the Wilcoxon–Mann–Whitney test. Clinical examples are used to illustrate our suggested testing methods.     

Adaptive phase I/II clinical trials for drug combination assessment in oncology using the outcomes of each cycle

Many new anticancer agents can be combined with existing drugs, as combining a number of drugs may be expected to have a better therapeutic effect than monotherapy owing to synergistic effects. Furthermore, to drive drug development and to reduce the associated cost, there has been a growing tendency to combine these as phase I/II trials. With respect to phase I/II oncology trials for the assessment of dose combinations, in the existing methodologies in which efficacy based on tumor response and safety based on toxicity are modeled as binary outcomes, it is not possible to enroll and treat the next cohort of patients unless the best overall response has been determined in the current cohort. Thus, the trial duration might be potentially extended to an unacceptable degree. In this study, we proposed a method that randomizes the next cohort of patients in the phase II part to the dose combination based on the estimated response rate using all the available observed data upon determination of the overall response in the current cohort. We compared the proposed method to the existing method using simulation studies. These demonstrated that the percentage of optimal dose combinations selected in the proposed method is not less than that in the existing method and that the trial duration in the proposed method is shortened compared to that in the existing method. The proposed method meets both ethical and financial requirements, and we believe it has the potential to contribute to expedite drug development.     

A stratified unrelated question randomized response model using Neyman allocation

This paper applies stratified random sampling using Neyman allocation to Mangat et al. (1992 Mangat, N.S., Singh, R., Singh, S. (1992). An improved unrelated question randomized response strategy. Cal. Stat. Assoc. Bull. 42:277–281.[Crossref] , [Google Scholar]) unrelated question randomized response (RR) strategy for both completely truthful reporting and less than completely truthful reporting. It is shown that, for the prior information given, our new model is more efficient in terms of variance (in the case of completely truthful reporting) and mean square error (in terms of less than completely truthful reporting) than Kim and Elam's (2007 Kim, J.M., Elam, M.E. (2007). A stratified unrelated question randomized response model. Stat. Papers 48:215–233.[Crossref], [Web of Science ®] , [Google Scholar]) model. Numerical illustrations and graphs are also given in support of the present study.     

An optional randomized response model for estimating a rare sensitive attribute using Poisson distribution

The crux of this article is to estimate the mean of the number of persons possessing a rare sensitive attribute based on the Mangat (1991 Mangat, N.S. (1991). An optional randomized response sampling technique using non–stigmatized attribute. Statistica. 51(4):595–602. [Google Scholar]) randomization device by utilizing the Poisson distribution in simple random sampling and stratified sampling. Properties of the proposed randomized response (RR) model have been studied along with recommendations. It is also shown that the proposed model is more efficient than that of Land et al. (2011 Land, M., Singh, S., Sedory, S.A. (2011). Estimation of a rare attribute using Poisson distribution. Statistics. 46(3):351–360.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) in simple random sampling and that of Lee et al. (2013 Lee, G.S., Uhm, D., Kim, J.M. (2013). Estimation of a rare sensitive attribute in stratified sampling using Poisson distribution. Statistics. 47(3):575–589.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) in stratified random sampling when the proportion of persons possessing a rare unrelated attribute is known. Numerical illustrations are also given in support of the present study.     

The effect of product-harm crisis situations on firms’ spokesperson strategies: Evidence from China's emerging market economy

The purpose of this paper is to examine the influence product-harm crisis situations have on, a firm's spokesperson strategies in China's emerging market economy. Through the content analysis of, 127 product-harm crises, crisis type is found to be a predictor of spokesperson strategies. Compared, with Chinese brands, foreign brands are less likely to employ top-executive spokesperson strategies, during product-harm crises. Crisis severity was found to have no impact on the adoption of, spokesperson strategies.     

Examining the interplay of an organization's prior reputation,CEO's visibility,and immediate response to a crisis

In one of only a few crisis communication research studies taking a relational approach, examining the effects of a company's prior reputation in publics’ responses to a given crisis situation, Lyons and Cameron (2004) found that both reputation and response profoundly affected publics’ attitude and behavioral intentions toward an organization involved in a crisis situation, using hypothetical, fictitious organizations and crises. Using actual organizations and crises, our research team designed a 2 (reputation: good vs. bad) × 2 (crisis response: apologetic vs. defensive) × 2 (CEO visibility in immediate crisis response: visible vs. invisible) within-subjects experiment (N = 102) to examine the variances in stakeholders’ attitudes and behavioral intentions toward a company after being exposed to online video that delivered a corporate crisis response. Findings were counter-intuitive: a defensive response to a crisis is as acceptable to crisis stakeholders as an apologetic response if the CEO is visible (or audible) in the response and if the pre-crisis company-stakeholder reputation is positive. Good reputation, defensive crisis response and CEO visibility in immediate response to a crisis resulted in the best stakeholder attitudes and purchase intentions.     

Initial teacher training: understanding ‘race,’ diversity and inclusion

There is little research which has explored how students on Initial Teacher Training (ITT) courses understand and conceptualise discourses of ‘race’, diversity and inclusion. This article will focus on student understandings of racialised identities; it will explore the discourses by which students understand what it means to be White and what it means to be Black, within the context of ITT. The article will examine the different facets and themes of identity within the context of belonging and exclusion which exist within higher education in the cultural and social contexts of English universities. The findings indicate that students’ understandings of ‘race’, diversity and inclusion on ITT courses are complex and multifaceted. The article argues that greater training is needed in relation to the practical assistance that student teachers require in terms of increasing their understanding of diversity and dealing with racism in the classroom.     

论《傲慢与偏见》反讽色彩在译本中的欠额翻译

反讽可以达到戏谑、嘲弄及讽刺的效果,使作品生动幽默,富有艺术感染力。反讽在《傲慢与偏见》中塑造了鲜活的人物形象,使作品妙趣横生,令读者百读不厌。因此,成功的译文必须将其完全再现出来。然而,在阅读三个中文译本的过程中发现存在反讽的欠额翻译现象。从语言学角度分析了其原因,并给出了新的翻译建议,指出译者不仅要具备足够的源语文化和语言知识,还必须具有熟练驾驭目标语的能力,才能避免反讽的欠额翻译,达到译语读者和源语读者反应的对等。     

马克思主义的时代回应

在深入领会“三个代表”重要思想的科学内涵,特别是“代表中国先进文化的前进方向”的基础上,正确运用汤因比“挑战——应战”模式,分析世界和中国哲学界存在的各种思潮之间,包括主流和边缘之间的互动关系,可以看出“三个代表”重要思想是对于现代挑战的应战。