An EM type estimation procedure for the destructive exponentially weighted Poisson regression cure model under generalized gamma lifetime

In this paper, we assume the number of competing causes to follow an exponentially weighted Poisson distribution. By assuming the initial number of competing causes can undergo destruction and that the population of interest has a cure fraction, we develop the EM algorithm for the determination of the MLEs of the model parameters of such a general cure model. This model is more flexible than the promotion time cure model and also provides an interesting and realistic interpretation of the biological mechanism of the occurrence of an event of interest. Instead of assuming a particular parametric distribution for the lifetime, we assume the lifetime to belong to the wider class of generalized gamma distribution. This allows us to carry out a model discrimination to select a parsimonious lifetime distribution that provides the best fit to the data. Within the EM framework, a two-way profile likelihood approach is proposed to estimate the shape parameters. An extensive Monte Carlo simulation study is carried out to demonstrate the performance of the proposed estimation method. Model discrimination is carried out by means of the likelihood ratio test and information-based methods. Finally, a data on melanoma is analyzed for illustrative purpose.     

LEVERAGE ADJUSTMENTS FOR DISPERSION MODELLING IN GENERALIZED NONLINEAR MODELS

For normal linear models, it is generally accepted that residual maximum likelihood estimation is appropriate when covariance components require estimation. This paper considers generalized linear models in which both the mean and the dispersion are allowed to depend on unknown parameters and on covariates. For these models there is no closed form equivalent to residual maximum likelihood except in very special cases. Using a modified profile likelihood for the dispersion parameters, an adjusted score vector and adjusted information matrix are found under an asymptotic development that holds as the leverages in the mean model become small. Subsequently, the expectation of the fitted deviances is obtained directly to show that the adjusted score vector is unbiased at least to O(1/n) . Exact results are obtained in the single‐sample case. The results reduce to residual maximum likelihood estimation in the normal linear case.     

A multivariate von mises distribution with applications to bioinformatics

Motivated by problems of modelling torsional angles in molecules, Singh, Hnizdo & Demchuk (2002) proposed a bivariate circular model which is a natural torus analogue of the bivariate normal distribution and a natural extension of the univariate von Mises distribution to the bivariate case. The authors present here a multivariate extension of the bivariate model of Singh, Hnizdo & Demchuk (2002). They study the conditional distributions and investigate the shapes of marginal distributions for a special case. The methods of moments and pseudo‐likelihood are considered for the estimation of parameters of the new distribution. The authors investigate the efficiency of the pseudo‐likelihood approach in three dimensions. They illustrate their methods with protein data of conformational angles     

Shared gamma frailty models based on reversed hazard rate for modeling Australian twin data

In this paper, we consider shared gamma frailty model with the reversed hazard rate (RHR) with two different baseline distributions, namely the generalized inverse Rayleigh and the exponentiated Gumbel distributions. With these two baseline distributions we propose two different shared frailty models. We develop the Bayesian estimation procedure using Markov Chain Monte Carlo technique to estimate the parameters involved in these models. We present a simulation study to compare the true values of the parameters with the estimated values. A search of the literature suggests that currently no work has been done for these two baseline distributions with a shared gamma frailty with the RHR so far. We also apply these two models by using a real life bivariate survival data set of Australian twin data given by Duffy et a1. (1990) and a better model is suggested for the data.     

EXACT DISTRIBUTION OF CERTAIN GENERAL TEST STATISTICS IN MULTIVARIATE ANALYSIS

In this paper, exact solution of Wilks' type-B integral equation has been obtained in its most general form as a series of weighted gamma distributions. This general result then gives the distributions of many test statistics in multivariate analysis. In particular the distributions of Wilks' Λ, the sphericity test criterion, and Bartlett's test statistic, are derived in easily computable form.     

Assessing gamma frailty models for clustered failure time data

Proportional hazards frailty models use a random effect, so called frailty, to construct association for clustered failure time data. It is customary to assume that the random frailty follows a gamma distribution. In this paper, we propose a graphical method for assessing adequacy of the proportional hazards frailty models. In particular, we focus on the assessment of the gamma distribution assumption for the frailties. We calculate the average of the posterior expected frailties at several followup time points and compare it at these time points to 1, the known mean frailty. Large discrepancies indicate lack of fit. To aid in assessing the goodness of fit, we derive and estimate the standard error of the mean of the posterior expected frailties at each time point examined. We give an example to illustrate the proposed methodology and perform sensitivity analysis by simulations.     

Approximations to noncentral distributions

Two methods for approximating the distribution of a noncentral random variable by a central distribution in the same family are presented. The first consists of relating a stochastic expansion of a random variable to a corresponding asymptotic expansion for its distribution function. The second approximates the cumulant generating function and is used to provide central χ² and gamma approximations to the noncentral χ² and gamma distributions.     

Dispersive ordering—Some applications and examples

A basic concept for comparing spread among probability distributions is that of dispersive ordering. Let X and Y be two random variables with distribution functions F and G, respectively. Let F ⁻¹ and G ⁻¹ be their right continuous inverses (quantile functions). We say that Y is less dispersed than X (Y≤ _disp X) if G ⁻¹(β)−G ⁻¹(α)≤F ⁻¹(β)−F ⁻¹(α), for all 0<α≤β<1. This means that the difference between any two quantiles of G is smaller than the difference between the corresponding quantiles of F. A consequence of Y≤ _disp X is that |Y ₁−Y ₂| is stochastically smaller than |X ₁−X ₂| and this in turn implies var(Y)≤var(X) as well as E[|Y ₁−Y ₂|]≤E[|X ₁−X ₂|], where X ₁, X ₂ (Y ₁, Y ₂) are two independent copies of X(Y). In this review paper, we give several examples and applications of dispersive ordering in statistics. Examples include those related to order statistics, spacings, convolution of non-identically distributed random variables and epoch times of non-homogeneous Poisson processes. This work was supported in part by KOSEF through Statistical Research Center for Complex Systems at Seoul National University. Subhash Kochar is thankful to Dr. B. Khaledi for many helpful discussions.     

A zero-augmented gamma mixed model for longitudinal data with many zeros

In many occupational safety interventions, the objective is to reduce the injury incidence as well as the mean claims cost once injury has occurred. The claims cost data within a period typically contain a large proportion of zero observations (no claim). The distribution thus comprises a point mass at 0 mixed with a non-degenerate parametric component. Essentially, the likelihood function can be factorized into two orthogonal components. These two components relate respectively to the effect of covariates on the incidence of claims and the magnitude of claims, given that claims are made. Furthermore, the longitudinal nature of the intervention inherently imposes some correlation among the observations. This paper introduces a zero-augmented gamma random effects model for analysing longitudinal data with many zeros. Adopting the generalized linear mixed model (GLMM) approach reduces the original problem to the fitting of two independent GLMMs. The method is applied to evaluate the effectiveness of a workplace risk assessment teams program, trialled within the cleaning services of a Western Australian public hospital.     

The distribution of random determinants

The exact distribution of |Δn| where Δn is a random determinant with independent and identically distributed exponential elements is given for the cases n = 2 and 3. From the investigation of the behaviour of the density functions for these cases it is conjectured that for any fixed n, the probability density of |Δn| for large values of the argument is the same as the density of (Y/n)ⁿ, where Y is a gamma random variable.