Human Salmonellosis: Estimation of Dose-Illness from Outbreak Data

The quantification of the relationship between the amount of microbial organisms ingested and a specific outcome such as infection, illness, or mortality is a key aspect of quantitative risk assessment. A main problem in determining such dose-response models is the availability of appropriate data. Human feeding trials have been criticized because only young healthy volunteers are selected to participate and low doses, as often occurring in real life, are typically not considered. Epidemiological outbreak data are considered to be more valuable, but are more subject to data uncertainty. In this article, we model the dose-illness relationship based on data of 20 Salmonella outbreaks, as discussed by the World Health Organization. In particular, we model the dose-illness relationship using generalized linear mixed models and fractional polynomials of dose. The fractional polynomial models are modified to satisfy the properties of different types of dose-illness models as proposed by Teunis et al . Within these models, differences in host susceptibility (susceptible versus normal population) are modeled as fixed effects whereas differences in serovar type and food matrix are modeled as random effects. In addition, two bootstrap procedures are presented. A first procedure accounts for stochastic variability whereas a second procedure accounts for both stochastic variability and data uncertainty. The analyses indicate that the susceptible population has a higher probability of illness at low dose levels when the combination pathogen-food matrix is extremely virulent and at high dose levels when the combination is less virulent. Furthermore, the analyses suggest that immunity exists in the normal population but not in the susceptible population.     

土家族历史上的传统分配和交换制度研究

土家族长期繁衍生息于湘鄂渝黔边的武陵山区，受这里的自然环境和历史上生产力状况的影响，形成了这个民族在生产中的许多特点。尤其是土家族的传统分配和交换制度在阶级社会中仍然保留着原始民族的一般互惠性分配方式的遗迹，在封建社会的产品交换中仍然表现出浓厚的等价互惠性。但是，由于阶级的出现，传统的分配和交换已打上了阶级压迫的烙印。     

Bootstrap Estimation of Benchmark Doses and Confidence Limits with Clustered Quantal Data

The benchmark dose (BMD) is an exposure level that would induce a small risk increase (BMR level) above the background. The BMD approach to deriving a reference dose for risk assessment of noncancer effects is advantageous in that the estimate of BMD is not restricted to experimental doses and utilizes most available dose-response information. To quantify statistical uncertainty of a BMD estimate, we often calculate and report its lower confidence limit (i.e., BMDL), and may even consider it as a more conservative alternative to BMD itself. Computation of BMDL may involve normal confidence limits to BMD in conjunction with the delta method. Therefore, factors, such as small sample size and nonlinearity in model parameters, can affect the performance of the delta method BMDL, and alternative methods are useful. In this article, we propose a bootstrap method to estimate BMDL utilizing a scheme that consists of a resampling of residuals after model fitting and a one-step formula for parameter estimation. We illustrate the method with clustered binary data from developmental toxicity experiments. Our analysis shows that with moderately elevated dose-response data, the distribution of BMD estimator tends to be left-skewed and bootstrap BMDL s are smaller than the delta method BMDL s on average, hence quantifying risk more conservatively. Statistically, the bootstrap BMDL quantifies the uncertainty of the true BMD more honestly than the delta method BMDL as its coverage probability is closer to the nominal level than that of delta method BMDL. We find that BMD and BMDL estimates are generally insensitive to model choices provided that the models fit the data comparably well near the region of BMD. Our analysis also suggests that, in the presence of a significant and moderately strong dose-response relationship, the developmental toxicity experiments under the standard protocol support dose-response assessment at 5% BMR for BMD and 95% confidence level for BMDL.     

水资源跨流域配置的经济学分析

由于我国水资源空间分布不均匀的突出特点 ,大型跨流域调水工程已经成为我国国民经济可持续发展的重要支撑。文章从水资源的经济特点出发 ,结合南水北调中线工程 ,对水资源跨流域配置的市场供求、成本收益等资源经济学问题进行了分析 ,并对社会主义市场经济条件下水资源跨流域配置的利益分配机制进行了探讨     

A note on LeCam’s bound for the distance between the Poisson binomial and the Poisson distribution

n possibly different success probabilities p ₁, p ₂, ..., p _n is frequently approximated by a Poisson distribution with parameter λ = p ₁ + p ₂ + ... + p _n . LeCam's bound p ² ₁ + p ² ₂ + ... + p _n ² for the total variation distance between both distributions is particularly useful provided the success probabilities are small. The paper presents an improved version of LeCam's bound if a generalized d-dimensional Poisson binomial distribution is to be approximated by a compound Poisson distribution. Received: May 10, 2000; revised version: January 15, 2001     

随机变量投影的一种应用

利用随机变量的投影关系,定义了偏方差矩阵,从而导出了逆方差阵元素的一种形式在随机变量是正态的条件,它为判别条件独立性有方便的操作办法。     

Mapping water quality by local scoring

The mean density of bacteria in a water body is commonly monitored using quantal assay. This paper describes the use of local scoring in estimating the spatial distribution of mean density from quantal assay results at a set of point locations. An application to estimating the mean density of fecal conform bacteria in a coastal pond is presented. Model diagnostics based on a parametric bootstrap are also presented.     

用Powell法求颗粒尺寸分布

本文用最优化理论中的Powell直接法求激光粒度仪中的颗粒尺寸分布。数值模拟及对标准颗粒的实测表明,该算法的计算精度高,能较好地解决粒度仪通常存在的计算结果随初始设定值变化的多值性问题。     

In Memoriam: Emeritus Professor Henry Oliver Lancaster, AO FAA 1 February 1913 – 2 December 2001

The death, in Sydney, of Oliver Lancaster marks the end of an era in the histories of the Statistical Society of Australia, which (in its previous existence as the Statistical Society of New South Wales) he helped found in 1947, and of the Australian Journal of Statistics of which he was founding editor (1959–1971). Oliver Lancaster was Foundation Professor of Mathematical Statistics at the University of Sydney (1959–1978), where he spent his life as student and academic. During his academic career, he achieved scholarly distinction in at least four fields: mathematical statistics, medical and public health statistics, the history of medicine and of statistics, and statistical bibliography. With E.J.G. Pitman (1897–1993), M.H. Belz (1897–1975), E.A. Cornish (1909–1973) and P.A.P. Moran (1917–1988) he was part of a cohort of renowned Australian mathematical statisticians who laid the foundation of the glory days of Australian mathematical statistics. This obituary and tribute focuses on some of these aspects, within a broader historical picture.     

Confidence Intervals for Current Status Data

Abstract.  The likelihood ratio statistic for testing pointwise hypotheses about the survival time distribution in the current status model can be inverted to yield confidence intervals (CIs). One advantage of this procedure is that CIs can be formed without estimating the unknown parameters that figure in the asymptotic distribution of the maximum likelihood estimator (MLE) of the distribution function. We discuss the likelihood ratio-based CIs for the distribution function and the quantile function and compare these intervals to several different intervals based on the MLE. The quantiles of the limiting distribution of the MLE are estimated using various methods including parametric fitting, kernel smoothing and subsampling techniques. Comparisons are carried out both for simulated data and on a data set involving time to immunization against rubella. The comparisons indicate that the likelihood ratio-based intervals are preferable from several perspectives.