Fairness of the national health service in Italy: a bivariate correlated random effects model

The primary purpose of this paper is to comprehensively assess households’ burden due to health payments. Starting from the fairness approach developed by the World Health Organization, we analyse the burden of healthcare payments on Italian households by modeling catastrophic payments and impoverishment due to healthcare expenditures. For this purpose, we propose to extend the analysis of fairness in financing contribution through a generalized linear mixed models by introducing a bivariate correlated random effects model, where association between the outcomes is modeled through individual- and outcome-specific latent effects which are assumed to be correlated. We discuss model parameter estimation in a finite mixture context. By using such model specification, the fairness of the Italian national health service is investigated.     

Is Marriage More Than Cohabitation? Well‐Being Differences in 30 European Countries

The study aims to assess, first, whether there is a gap in well‐being between unmarried cohabitants and the married, second, if selection factors can explain this so‐called cohabitation gap, and third, if the size of the cohabitation gap differs across countries and how this can be explained. We use pooled data from young adults (18–44) in 3 rounds of the European Social Survey (N ? 31, 500). Multilevel regression analyses show that there is a moderate cohabitation gap that can be partly explained with the selection factors material resources and religiosity. Country differences were clear and could partly be explained with the level of institutionalization: In countries where cohabitation is more accepted and more prevalent, the cohabitation gap is smaller.     

Spatially-adaptive Penalties for Spline Fitting

The paper studies spline fitting with a roughness penalty that adapts to spatial heterogeneity in the regression function. The estimates are p th degree piecewise polynomials with p − 1 continuous derivatives. A large and fixed number of knots is used and smoothing is achieved by putting a quadratic penalty on the jumps of the p th derivative at the knots. To be spatially adaptive, the logarithm of the penalty is itself a linear spline but with relatively few knots and with values at the knots chosen to minimize the generalized cross validation (GCV) criterion. This locally-adaptive spline estimator is compared with other spline estimators in the literature such as cubic smoothing splines and knot-selection techniques for least squares regression. Our estimator can be interpreted as an empirical Bayes estimate for a prior allowing spatial heterogeneity. In cases of spatially heterogeneous regression functions, empirical Bayes confidence intervals using this prior achieve better pointwise coverage probabilities than confidence intervals based on a global-penalty parameter. The method is developed first for univariate models and then extended to additive models.     

Multichannel electroencephalographic analyses via dynamic regression models with time-varying lag–lead structure

Multiple time series of scalp electrical potential activity are generated routinely in electroencephalographic (EEG) studies. Such recordings provide important non-invasive data about brain function in human neuropsychiatric disorders. Analyses of EEG traces aim to isolate characteristics of their spatiotemporal dynamics that may be useful in diagnosis, or may improve the understanding of the underlying neurophysiology or may improve treatment through identifying predictors and indicators of clinical outcomes. We discuss the development and application of non-stationary time series models for multiple EEG series generated from individual subjects in a clinical neuropsychiatric setting. The subjects are depressed patients experiencing generalized tonic–clonic seizures elicited by electroconvulsive therapy (ECT) as antidepressant treatment. Two varieties of models—dynamic latent factor models and dynamic regression models—are introduced and studied. We discuss model motivation and form, and aspects of statistical analysis including parameter identifiability, posterior inference and implementation of these models via Markov chain Monte Carlo techniques. In an application to the analysis of a typical set of 19 EEG series recorded during an ECT seizure at different locations over a patient's scalp, these models reveal time-varying features across the series that are strongly related to the placement of the electrodes. We illustrate various model outputs, the exploration of such time-varying spatial structure and its relevance in the ECT study, and in basic EEG research in general.     

Bayesian integrative analysis for multi-fidelity computer experiments

This paper proposes a Bayesian integrative analysis method for linking multi-fidelity computer experiments. Instead of assuming covariance structures of multivariate Gaussian process models, we handle the outputs from different levels of accuracy as independent processes and link them via a penalization method that controls the distance between their overall trends. Based on the priors induced by the penalty, we build Bayesian prediction models for the output at the highest accuracy. Simulated and real examples show that the proposed method is better than existing methods in terms of prediction accuracy for many cases.     

Skew-mixed effects model for multivariate longitudinal data with categorical outcomes and missingness

A longitudinal study commonly follows a set of variables, measured for each individual repeatedly over time, and usually suffers from incomplete data problem. A common approach for dealing with longitudinal categorical responses is to use the Generalized Linear Mixed Model (GLMM). This model induces the potential relation between response variables over time via a vector of random effects, assumed to be shared parameters in the non-ignorable missing mechanism. Most GLMMs assume that the random-effects parameters follow a normal or symmetric distribution and this leads to serious problems in real applications. In this paper, we propose GLMMs for the analysis of incomplete multivariate longitudinal categorical responses with a non-ignorable missing mechanism based on a shared parameter framework with the less restrictive assumption of skew-normality for the random effects. These models may contain incomplete data with monotone and non-monotone missing patterns. The performance of the model is evaluated using simulation studies and a well-known longitudinal data set extracted from a fluvoxamine trial is analyzed to determine the profile of fluvoxamine in ambulatory clinical psychiatric practice.     

A self-normalizing approach to the specification test of mixed-frequency models

In econometrics and finance, variables are collected at different frequencies. One straightforward regression model is to aggregate the higher frequency variable to match the lower frequency with a fixed weight function. However, aggregation with fixed weight functions may overlook useful information in the higher frequency variable. On the other hand, keeping all higher frequencies may result in overly complicated models. In literature, mixed data sampling (MIDAS) regression models have been proposed to balance between the two. In this article, a new model specification test is proposed that can help decide between the simple aggregation and the MIDAS model.     

Sparse matrices,and the estimation of variance components by likelihood methods

It is generally considered that analysis of variance by maximum likelihood or its variants is computationally impractical, despite existing techniques for reducing computational effect per iteration and for reducing the number of iterations to convergence. This paper shows thata major reduction in the overall computational effort can be achieved through the use of sparse-matrix algorithms that take advantage of the factorial designs that characterize most applications of large analysis-of-variance problems. In this paper, an algebraic structure for factorial designsis developed. Through this structure, it is shown that the required computations can be arranged so that sparse-matrix methods result in greatly reduced storage and time requirements.     

Search With Dirichlet Priors: Estimation and Implications for Consumer Demand

This article is an empirical application of the search model with an unknown distribution, as introduced by Rothschild in 1974. For searchers who hold Dirichlet priors, we develop a novel characterization of optimal search behavior. Our solution delivers easily computable formulas for the ex-ante purchase probabilities as outcomes of search, as required by discrete-choice-based estimation. Using our method, we investigate the consequences of consumer learning on the properties of search-generated demand. Holding search costs constant, the search model from a known distribution predicts larger price elasticities, mainly for the lower-priced products. We estimate a search model with Dirichlet priors, on a dataset of prices and market shares of S&P 500 mutual funds. We find that the assumption of no uncertainty in consumer priors leads to substantial biases in search cost estimates.