浅谈洁净手术部在医院基建工程中的特殊需求

随着现代医学的发展,洁净手术部成为各手术学科建设与发展的重要前提与支柱,对原有手术室功能进行改造势在必行。为了实现医院洁净手术部向信息化、智能化、集约化发展,从洁净手术部的选址、功能等方面介绍了当前省内部分二级以上医疗单位洁净手术室建设的新进展,总结近年来在洁净手术室规划、建设过程中的经验,为现代医院基建工程管理提供借鉴,保障医院医疗、教学、科研工作的顺利开展。     

An improved two-stage procedure to compare hazard curves

Qiu and Sheng has proposed a powerful and robust two-stage procedure to compare two hazard rate functions. In this paper we improve their method by using the Fisher test to combine the asymptotically independent p-values obtained from the two stages of their procedure. In addition, we extend the procedure to situations with multiple hazard rate functions. Our comprehensive simulation study shows that the proposed method has a good performance in terms of controlling the type I error rate and of detecting power. Three real data applications are considered for illustrating the use of the new method.     

Generalizing the standardized hazard ratio to multivariate proportional hazards regression,with an application to clinical~genomic studies

The standardized hazard ratio for univariate proportional hazards regression is generalized as a scalar to multivariate proportional hazards regression. Estimators of the standardized log hazard ratio are developed, with corrections for bias and for regression to the mean in high-dimensional analyses. Tests of point and interval null hypotheses and confidence intervals are constructed. Cohort sampling study designs, commonly used in prospective–retrospective clinical genomic studies, are accommodated.     

充分发挥大众传媒思想政治教育功能的对策研究

本文归纳总结了切实发挥大众传媒思想政治教育功能应遵循的基本原则,深入分析当前我国发挥大众传媒思想政治教育功能的现状、存在的主要问题以及导致这些问题的原因,并进而深入挖掘隐藏在这些问题背后的深层次制约因素,提出了如何充分发挥大众传媒思想政治教育功能的对策性意见。     

A simple algorithm for calculating values for folded normal distribution

Folded normal distribution originates from the modulus of normal distribution. In the present article, we have formulated the cumulative distribution function (cdf) of a folded normal distribution in terms of standard normal cdf and the parameters of the mother normal distribution. Although cdf values of folded normal distribution were earlier tabulated in the literature, we have shown that those values are valid for very particular situations. We have also provided a simple approach to obtain values of the parameters of the mother normal distribution from those of the folded normal distribution. These results find ample application in practice, for example, in obtaining the so-called upper and lower α-points of folded normal distribution, which, in turn, is useful in testing of the hypothesis relating to folded normal distribution and in designing process capability control chart of some process capability indices. A thorough study has been made to compare the performance of the newly developed theory to the existing ones. Some simulated as well as real-life examples have been discussed to supplement the theory developed in this article. Codes (generated by R software) for the theory developed in this article are also presented for the ease of application.     

Testing for parameter constancy in the time series direction in panel data models

We propose tests for parameter constancy in the time series direction in panel data models. We construct a locally best invariant test based on Tanaka [Time series analysis: nonstationary and noninvertible distribution theory. New York: Wiley; 1996] and an asymptotically point optimal test based on Elliott and Müller [Efficient tests for general persistent time variation in regression coefficients. Rev Econ Stud. 2006;73:907–940]. We derive the limiting distributions of the test statistics as T→∞ while N is fixed, and calculate the critical values by applying numerical integration and response surface regression. Simulation results show that the proposed tests perform well if we apply them appropriately.     

General results for the Kumaraswamy-G distribution

For any continuous baseline G distribution [G.M. Cordeiro and M. de Castro, A new family of generalized distributions, J. Statist. Comput. Simul. 81 (2011), pp. 883–898], proposed a new generalized distribution (denoted here with the prefix ‘Kw-G’ (Kumaraswamy-G)) with two extra positive parameters. They studied some of its mathematical properties and presented special sub-models. We derive a simple representation for the Kw-G density function as a linear combination of exponentiated-G distributions. Some new distributions are proposed as sub-models of this family, for example, the Kw-Chen [Z.A. Chen, A new two-parameter lifetime distribution with bathtub shape or increasing failure rate function, Statist. Probab. Lett. 49 (2000), pp. 155–161], Kw-XTG [M. Xie, Y. Tang, and T.N. Goh, A modified Weibull extension with bathtub failure rate function, Reliab. Eng. System Safety 76 (2002), pp. 279–285] and Kw-Flexible Weibull [M. Bebbington, C.D. Lai, and R. Zitikis, A flexible Weibull extension, Reliab. Eng. System Safety 92 (2007), pp. 719–726]. New properties of the Kw-G distribution are derived which include asymptotes, shapes, moments, moment generating function, mean deviations, Bonferroni and Lorenz curves, reliability, Rényi entropy and Shannon entropy. New properties of the order statistics are investigated. We discuss the estimation of the parameters by maximum likelihood. We provide two applications to real data sets and discuss a bivariate extension of the Kw-G distribution.     

Using In Vitro High‐Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards

Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high‐throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k]fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline‐based meta‐regression can be used to integrate data across multiple assay replicates to generate a concentration–response curve. We used this analysis to calculate an in vitro point of departure of 0.751 μM and risk‐specific in vitro concentrations of 0.29 μM and 0.28 μM for 1:1,000 and 1:10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta‐regression, may allow risk assessors to identify points of departure and risk‐specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods.