泰乐松注射液的毒理学试验研究

为提供泰乐松注射液的安全性毒理学评价资料,本试验采用改进Karber法测定小鼠LD_(50);以剂量递增法测定小鼠蓄积性和耐受性;分别以剂量340、130、30mg／kg为3个试验组．设阴性和阳性对照组进行小鼠骨髓微核试验;分别以剂量500、250、120mg／kg为3个剂量组．设阴性和阳性对照组进行小鼠精于畸形试验。结果表明：其LD_(50)为669．80mg／kg,蓄积系数大于5．3,无明显蓄积毒性和耐受性（P＞0．05）,小鼠骨髓微核试验和精子畸形试验结果均为阴性。     

沪市认购权证与其标的股票价格走势的Granger因果检验

运用G ranger因果检验的方法,检验沪市6只认购权证与其标的股票之间的因果关系。分析结果表明:在大样本条件下,认购权证与其标的股票之间存在单向的G ranger因果关系,权证的价格走势影响其标的股票的价格走势,说明从长期来看,认购权证发挥了其潜在的投资杠杆的作用,其价值发现与风险对冲功能在市场中得到实现;在小样本条件下,认购权证与其标的股票之间不存在显著的G ranger因果关系,表明短期内权证与其标的股票价格走势相互独立,市场中有可能存在对权证投机炒作,人为放大权证的投资风险,使权证背离其正常的投资价值。     

Testing Inference in Inflated Beta Regressions under Model Misspecification

We consider testing inference in inflated beta regressions subject to model misspecification. In particular, quasi-z tests based on sandwich covariance matrix estimators are described and their finite sample behavior is investigated via Monte Carlo simulations. The numerical evidence shows that quasi-z testing inference can be considerably more accurate than inference made through the usual z tests, especially when there is model misspecification. Interval estimation is also considered. We also present an empirical application that uses real (not simulated) data.     

大型低速重载径向动压轴承研究

为了开发大型贯流式水轮发电机组径向轴承,在试验台上采用了360的模型轴承对1740可倾6瓦块原型轴承进行模拟试验研究,最高试验比压3.37 MPa、最低线速度3.77 m/s、最高线速度22.62 m/s。试验表明:载荷、进油压力、转速、进油温度和安装间隙比等,对轴承油温升、油流量、功耗、瓦温及油膜厚度等都存在不同程度的影响,其中载荷和转速的影响比较显著。按照模型轴承指导设计的红岩子机组1740轴承已在电站可靠运行,同时开发了径向轴承热弹流计算程序,可以预测径向轴承的油膜压力、油膜温度、油膜厚度、损耗、流量等参数。     

Influence Diagnostics on Testing Linear Hypothesis in Linear Models with Correlated Errors

To assess the influence of observations on the parameter estimates, case deletion diagnostics are commonly used in linear regression models. For linear models with correlated errors we study the influence of observations on testing a linear hypothesis using single and multiple case deletions. The change in likelihood ratio test and F test theoretically is derived and it is shown these tests to be completely determined by two proposed generalized externally studentized residuals. An illustrative example of a real data set is also reported.     

An algorithm for maximum likelihood estimation in incomplete block variance component models

In the recovery of interblock information to improve the treatment differences estimates in incomplete block designs, the parameter p is usually unknown. Many authors have worked on the problem of estimating it and of studying its properties together with the properties of the treatment differences estimates. In this paper a numerically efficient algorithm is developed which yields the maximum likelihood estimates (MLE) of all the parameters in the mixed incomplete block design model (treatment effects, ρ and variance)     

A goodness of fit test for the multilevel proportional odds model

It is essential to test the goodness of fit of the model before making inferences based on it. Multilevel modeling of ordinal categorical responses is not as developed as for continuous responses. Assessing model adequacy in terms of the goodness of fit with ordinal categorical responses is still being developed and no satisfactory tests are available so far. As a consequence of that, this study concentrates on developing such a goodness of fit test for Multilevel Proportional Odds models and to study the properties of the test.     

Accounting for Uncertainty in Heteroscedasticity in Nonlinear Regression

Toxicologists and pharmacologists often describe toxicity of a chemical using parameters of a nonlinear regression model. Thus estimation of parameters of a nonlinear regression model is an important problem. The estimates of the parameters and their uncertainty estimates depend upon the underlying error variance structure in the model. Typically, a priori the researcher would not know if the error variances are homoscedastic (i.e., constant across dose) or if they are heteroscedastic (i.e., the variance is a function of dose). Motivated by this concern, in this paper we introduce an estimation procedure based on preliminary test which selects an appropriate estimation procedure accounting for the underlying error variance structure. Since outliers and influential observations are common in toxicological data, the proposed methodology uses M-estimators. The asymptotic properties of the preliminary test estimator are investigated; in particular its asymptotic covariance matrix is derived. The performance of the proposed estimator is compared with several standard estimators using simulation studies. The proposed methodology is also illustrated using a data set obtained from the National Toxicology Program.     

Support for a Fluid-Continuum Model of Sexual Orientation: A Large-Scale Internet Study

In a study with 17,785 subjects obtained over the Internet from the United States and 47 other countries, Kinsey's hypothesis that sexual orientation lies on a continuum was supported. Self-identifications of subjects as gay, straight, bisexual, and other corresponded to broad, skewed distributions, suggesting that such terms are misleading for many people. Sexual orientation range—roughly, how much flexibility someone has in expressing sexual orientation—was also measured. The results support a fluid-continuum model of sexual orientation, according to which genetic and environmental factors determine both the size of the sexual orientation range and the point at which an individual's sexual orientation is centered on the continuum.     

On an asymptotic relative efficiency concept based on expected volumes of confidence regions

ABSTRACT

The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.