Graphical methods for comparing confounding in two or more designs

In many circumstances it is necessary to design an experiment with partial confounding of parameter estimates. In this situation, one would like to have tools to assess and compare candidate designs graphically. In this paper we discuss two graphical representations of design properties, and illustrate their application with two examples.     

A correlation-theoretical interpretation of schur analysis

This paper is heavily leaned on the author's recent investigations concerning SCHUR analysis of non-negative Hermitian block matrices. The parameters of the matrix balls and the triangular choice scheme which describe a non-negative Hermitian block matrix will be interpreted in the framework of correlation theory     

In Search of the Optimum Harvey Wallbanger Recipe via Mixture Experiment Techniques

A Harvey Wallbanger is an alcoholic drink composed of three ingredients: orange juice, vodka, and Galliano. One of the authors (Sahrmann), a connoisseur of the libation, was perplexed upon discovering that different bartender handbooks listed different recipes for the drink. Determined to shed some light on this irksome problem, he issued invitations for an evening workshop session (party) to former and current attendees of an experimental-design training course taught within his company. A mixture experiment was designed and data collected using the class participants. This article describes the experimental design and the analysis of the data. The results of the experiment indicate that reducing the proportion of vodka produces better-flavored drinks. The results of the experiment were not entirely conclusive, however, so recommendations are made for future experimentation.     

A formula for a missing plot in a general incomplete block design,when recovery of interblock information is used

In this paper, Yate's missing plot technique is used to derive the formula for substitution in a missing plot in a general incomplete block design, where blocks are assumed to be independent normal. The use of penalized normal equations, using BLUPS, makes this task simpler.     

A method for obtaining randomized block designs in preclinical studies with multiple quantitative blocking variables

A method is proposed for block randomization of treatments to experimental units that can accommodate both multiple quantitative blocking variables and unbalanced designs. Hierarchical clustering in conjunction with leaf‐order optimization is used to block experimental units in multivariate space. The method is illustrated in the context of a diabetic mouse assay. A simulation study is presented to explore the utility of the proposed randomization method relative to that of a completely randomized approach, both in the presence and absence of covariate adjustment. An example R function is provided to illustrate the implementation of the method. Copyright © 2010 John Wiley & Sons, Ltd.     

Exclusion restrictions in instrumental variables equations

In this paper we consider two-stage estimators of parameters of a structural equation in a model with recursive exclusion restrictions on the instrumental variables equations. The estimations considered are simple OLS and GLS estimators after substitution of estimates of the systematic part of the IV equations for the endogenous variables. It is known in the literature that neither imposing the restrictions in the first stage nor ignoring them will in general be more efficient than the alternative. We introduce a class of mixed instrumental variables estimators (MIV) with these possibilities as special cases which yields an estimator which is not only more efficient than the two stage estimators considered in the literature but as efficient as an efficient system estimator like 3SLS.     

On the recovery of intra- and interblock information in n-ary designs

This note presents an extension of Q-method of analysis for binary designs given by Rao (1956) to n-ary balanced and partially balanced block designs. Here a linked n-ary block (LNB) design is defined as the dual of balanced n-ary (BN) design. Having a note on Yates’ (1939, 1940) method of P-analysis, we further extend the expressions for binary linked block (LB) designs given by Rao (1956) to linked n-ary block (LNB) designs which admit easy estimation of parameters for these type of all n-ary designs.     

The mad estimator: when is it non-linear? applications to two-way design models

The mean absolute deviation (MAD) estimator has recently received a great deal of attention as applied to full-rank linear regression models. This paper provides a necessary and sufficient condition for the MAD estimator to be a non-linear estimator, in which case conditions for the variance of the MAD estimator to be larger or smaller than those for OLS are, in general, unknown. The non-linearity of the MAD estimator is examined for several two-way designs; in particular (1) randomized block design (2) two-way nested design (3) two-way classification with interaction and (4) partially balanced incomplete block design     

Chain graph models: topological sorting of meta-arrows and efficient construction of $${\mathcal{B}}$$ -essential graphs

Essential graphs and largest chain graphs are well-established graphical representations of equivalence classes of directed acyclic graphs and chain graphs respectively, especially useful in the context of model selection. Recently, the notion of a labelled block ordering of vertices was introduced as a flexible tool for specifying subfamilies of chain graphs. In particular, both the family of directed acyclic graphs and the family of “unconstrained” chain graphs can be specified in this way, for the appropriate choice of . The family of chain graphs identified by a labelled block ordering of vertices is partitioned into equivalence classes each represented by means of a -essential graph. In this paper, we introduce a topological ordering of meta-arrows and use this concept to devise an efficient procedure for the construction of -essential graphs. In this way we also provide an efficient procedure for the construction of both largest chain graphs and essential graphs. The key feature of the proposed procedure is that every meta-arrow needs to be processed only once.     

欧盟最新技术转让协议竞争规则研究

在知识经济时代,为了避免重复研发,并使技术的投入产出最大化,技术转让成为企业间的一项重要的交易内容。但是在促进技术创新的知识产权制度在保护创新技术的同时,在技术转让的过程中也会造成技术垄断和市场垄断,给市场公平竞争带来损害。欧盟是技术转让市场频繁和活跃的地区,随着经济的发展,欧盟修改了规制知识产权技术转让协议的竞争规则,通过以技术转让协议集体豁免条例为主的考察方法,全面、深入地分析相关竞争规则的立法背景、主要内容、特点及实践中的运行状况,特别是新协议中的安全港制度、经济分析的方法,为我国参与欧盟技术转让的企业提供借鉴。