Modified likelihood ratio tests in heteroskedastic multivariate regression models with measurement error

In this paper, we develop modified versions of the likelihood ratio test for multivariate heteroskedastic errors-in-variables regression models. The error terms are allowed to follow a multivariate distribution in the elliptical class of distributions, which has the normal distribution as a special case. We derive the Skovgaard-adjusted likelihood ratio statistics, which follow a chi-squared distribution with a high degree of accuracy. We conduct a simulation study and show that the proposed tests display superior finite sample behaviour as compared to the standard likelihood ratio test. We illustrate the usefulness of our results in applied settings using a data set from the WHO MONICA Project on cardiovascular disease.     

Goodness—of—fit for the two—parameter weibull distribution with estimated parameters

Goodness—of—fit statistics based on the empirical distribution function (EDF) are not distribution—free when parameters for the hypothesized distribution are estimated. Tables are percentile values of several EDF statistics are available for the two—parameter Weibull distribution when parameters are estimated by maximum likelihood. To determine how these tabled values change when simpler estimators are employed, percentile scores for EDF goodness—of—fit tests were obtained by Monte—Carlo simulation for maximum likelihood estimators (MLEs), good linear unbiased estimators (GLUEs), and modified Cramer—von Mises, Anderson—Darling, and Watson statistics are presented for GLUEs for both complete and censored samples. Critical values for Kolmogorov—Smirnov statistics were less affected by the method of estimation than were closer for MLEs and MGLUEs than for MGLUEs and GLUEs. On the other hand, MGLUE and GLUE results were much more similar to each other than to the MLE results when censoring was light and sample sizes were large.     

Exact distributions of two non-central generalized Wilks's statistics

We derive the exact expressions of the probability density function (pdf) and the cumulative distribution function (cdf) of Wilks's likelihood ratio criterion Λ and Wilks-Lawley's statistic U in the non-central linear and the non-central planar cases. Those expressions are given in rapidly converging infinite series and can be used for numerical computation. For applications, we compute the exact power of these statistics in a multivariate analysis of variance exercise, and show by simulation the precision of our analytic formulae.     

The exponential distribution analog of the Grubbs–Weaver method

Abstract

Grubbs and Weaver (1947 Grubbs, F. E., and C. L. Weaver. 1947. The best unbiased estimate of population standard deviation based on group ranges. Journal of the American Statistical Association 42 (238):224–41. doi: 10.2307/2280652.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) suggest a minimum-variance unbiased estimator for the population standard deviation of a normal random variable, where a random sample is drawn and a weighted sum of the ranges of subsamples is calculated. The optimal choice involves using as many subsamples of size eight as possible. They verified their results numerically for samples of size up to 100, and conjectured that their “rule of eights” is valid for all sample sizes. Here we examine the analogous problem where the underlying distribution is exponential and find that a “rule of fours” yields optimality and prove the result rigorously.     

Testing for Serial Independence: Beyond the Portmanteau Approach

Portmanteau tests are typically used to test serial independence even if, by construction, they are generally powerful only in presence of pairwise dependence between lagged variables. In this article, we present a simple statistic defining a new serial independence test, which is able to detect more general forms of dependence. In particular, differently from the Portmanteau tests, the resulting test is powerful also under a dependent process characterized by pairwise independence. A diagram, based on p-values from the proposed test, is introduced to investigate serial dependence. Finally, the effectiveness of the proposal is evaluated in a simulation study and with an application on financial data. Both show that the new test, used in synergy with the existing ones, helps in the identification of the true data-generating process. Supplementary materials for this article are available online.     

The generalized odd half-Cauchy family of distributions: Properties and applications

We introduce and study general mathematical properties of a new generator of continuous distributions with one extra parameter called the generalized odd half-Cauchy family. We present some special models and investigate the asymptotics and shapes. The new density function can be expressed as a linear mixture of exponentiated densities based on the same baseline distribution. We derive a power series for the quantile function. We discuss the estimation of the model parameters by maximum likelihood and prove empirically the flexibility of the new family by means of two real data sets.     

Asymptotic hypothesis test to simultaneously compare the weighted kappa coefficients of multiple binary diagnostic tests in the presence of ignorable missing data

The weighted kappa coefficient of a binary diagnostic test is a measure of the beyond-chance agreement between the diagnostic test and the gold standard, and is a measure that allows us to assess and compare the performance of binary diagnostic tests. In the presence of partial disease verification, the comparison of the weighted kappa coefficients of two or more binary diagnostic tests cannot be carried out ignoring the individuals with an unknown disease status, since the estimators obtained would be affected by verification bias. In this article, we propose a global hypothesis test based on the chi-square distribution to simultaneously compare the weighted kappa coefficients when in the presence of partial disease verification the missing data mechanism is ignorable. Simulation experiments have been carried out to study the type I error and the power of the global hypothesis test. The results have been applied to the diagnosis of coronary disease.     

Locally best invariant test for outliers in a gamma type distribution

It is shown that the locally best invariant test for the existence of outliers for scale parameters of the gamma distribution is given by Bartholomew's test for exponentiality which is the ratio of the sum of squares of the data to the square of the sample mean. The optimality robustness, including null and nonnull robustness of the test is shown. A small simulation study to compare the power among the other eight competitive tests for testing exponentiality is performed. It is seen that the locally best invariant test is not always best but is reasonably good. It is slightly better than Cochran's test and suffers less from the limiting masking effect.     

Group sequential monitoring based on the weighted log‐rank test statistic with the Fleming–Harrington class of weights in cancer vaccine studies

In recent years, immunological science has evolved, and cancer vaccines are now approved and available for treating existing cancers. Because cancer vaccines require time to elicit an immune response, a delayed treatment effect is expected and is actually observed in drug approval studies. Accordingly, we propose the evaluation of survival endpoints by weighted log‐rank tests with the Fleming–Harrington class of weights. We consider group sequential monitoring, which allows early efficacy stopping, and determine a semiparametric information fraction for the Fleming–Harrington family of weights, which is necessary for the error spending function. Moreover, we give a flexible survival model in cancer vaccine studies that considers not only the delayed treatment effect but also the long‐term survivors. In a Monte Carlo simulation study, we illustrate that when the primary analysis is a weighted log‐rank test emphasizing the late differences, the proposed information fraction can be a useful alternative to the surrogate information fraction, which is proportional to the number of events. Copyright © 2016 John Wiley & Sons, Ltd.     

A Note on the Large Sample Properties of Estimators Based on Generalized Linear Models for Correlated Pseudo‐observations

Pseudo‐values have proven very useful in censored data analysis in complex settings such as multi‐state models. It was originally suggested by Andersen et al., Biometrika, 90, 2003, 335 who also suggested to estimate standard errors using classical generalized estimating equation results. These results were studied more formally in Graw et al., Lifetime Data Anal., 15, 2009, 241 that derived some key results based on a second‐order von Mises expansion. However, results concerning large sample properties of estimates based on regression models for pseudo‐values still seem unclear. In this paper, we study these large sample properties in the simple setting of survival probabilities and show that the estimating function can be written as a U‐statistic of second order giving rise to an additional term that does not vanish asymptotically. We further show that previously advocated standard error estimates will typically be too large, although in many practical applications the difference will be of minor importance. We show how to estimate correctly the variability of the estimator. This is further studied in some simulation studies.