Modifications of sequential designs in bioequivalence trials

Bioequivalence (BE) studies are designed to show that two formulations of one drug are equivalent and they play an important role in drug development. When in a design stage, it is possible that there is a high degree of uncertainty on variability of the formulations and the actual performance of the test versus reference formulation. Therefore, an interim look may be desirable to stop the study if there is no chance of claiming BE at the end (futility), or claim BE if evidence is sufficient (efficacy), or adjust the sample size. Sequential design approaches specially for BE studies have been proposed previously in publications. We applied modification to the existing methods focusing on simplified multiplicity adjustment and futility stopping. We name our method modified sequential design for BE studies (MSDBE). Simulation results demonstrate comparable performance between MSDBE and the original published methods while MSDBE offers more transparency and better applicability. The R package MSDBE is available at https://sites.google.com/site/modsdbe/ . Copyright © 2015 John Wiley & Sons, Ltd.     

Maternal and paternal reactions to child sadness predict children's psychosocial outcomes: A family‐centered approach

Parents' reactions to children's emotions shape their psychosocial outcomes. Extant research on emotion socialization primarily uses variable‐centered approaches. This study explores family patterns of maternal and paternal responses to children's sadness in relation to psychosocial outcomes in middle childhood. Fifty‐one families with 8‐ to 12‐year‐old children participated. Mothers and fathers reported their reactions to children's sadness and children's social competence and psychological adjustment. Cluster analyses revealed three family patterns: Supportive (high supportive and low non‐supportive reactions from both parents), Not Supportive (low supportive reactions from both parents), and Father Dominant (high paternal supportive and non‐supportive reactions, low maternal supportive and non‐supportive reactions). Supportive families had children with higher social competence and more internalizing symptoms whereas Father Dominant families had children with lower social competence and fewer internalizing symptoms. Not Supportive families had children with average social competence and fewer internalizing symptoms. Findings are discussed in relation to the “divergence model” which proposes that a diverse range of parental responses to children's sadness, rather than a uniformly supportive approach, may facilitate children's psychosocial adjustment.     

Land markets and migration trends in Tanzania: A qualitative‐quantitative analysis

While migration has been found to enhance welfare across a range of settings, most of the literature focuses on rural‐to‐urban migrant flows. Using a unique dataset from north‐western Tanzania, this article probes an important, yet overlooked, link between land markets and rural‐to‐rural migration. A mixed‐methods approach is used to discern how these two forces are intertwined in village life. Results indicate that household decisions to migrate are particularly influenced by the ease of market‐based land access in their new communities. This suggests that labour mobility may be facilitated through the development of a well‐functioning land market.     

Hill estimator of projections of functional data on principal components

Functional principal component scores are commonly used to reduce mathematically infinitely dimensional functional data to finite dimensional vectors. In certain applications, most notably in finance, these scores exhibit tail behaviour consistent with the assumption of regular variation. Knowledge of the index of the regular variation, α, is needed to apply methods of extreme value theory. The most commonly used method of the estimation of α is the Hill estimator. We derive conditions under which the Hill estimator computed from the sample scores is consistent for the tail index of the unobservable population scores.     

零售4.0时代先行发货问题的大数据分析

在零售4.0时代，渠道的多样化不仅丰富了数据源，还能迅速生成大量数据，需要通过分析大数据，为决策提取有意义的信息，通过分析先行发货的重要性，提出了一种基于遗传算法（GA）的优化模型，预测顾客何时购买，然后在顾客线下单前将产品运送到距顾客最近的配送中心，解决先行发货中存在的问题。研究认为，需要先部署云计算来存储所有渠道生成的大数据，再应用基于集群的关联规则挖掘研究顾客的购买行为，根据“如果-那么”预测规则预测未来的采购情况，最后利用修正的遗传算法生成最优的先行发货计划；这种遗传算法考虑了其在运输成本和运输距离之外，还有预测规则的置信度，利用大量的数值实验权衡了先行发货中的不同因素，验证了模型的最优可靠性     

论数字货币的私法性质——以日本Bitcoin.Cafe数字货币交易所破产案为中心

数字货币，是一种具有财产性价值属性的电磁记录型数据。数字货币在其依存的区块链体系中所彰显的与不特定者之间的支付对价性、与法定货币之间的互换性、使用电子信息处理系统进行转移的在线转移性等特点，得以从数据说的角度，将其作为一种数据性财产权在现行法律框架内对其私法性质进行讨论。有鉴于我国民法总则已将数据纳入保护客体的范畴，数字货币作为数据之一种，理应成为一种新型法律客体，在得到法律理论支撑的基础上获得保护。     

Parental Divorce and Interpersonal Trust in Adult Offspring

It has been proposed that recent increases in parental divorce have inhibited the development of trust among offspring. This proposition is tested by examining whether parental divorce is associated with offspring trust in parents, intimate partners, and others. Data come from the Marital Instability Over the Life Course Study. Results reveal that although parental divorce is negatively associated with trust, these effects largely disappear once the quality of the past parent‐teen relationship is taken into account. The one exception is trust in fathers where children of divorce remain at higher risk of mistrust. Trust in parents, intimates, and others is strongly linked to positive parent‐teen relationships regardless of parental divorce. Contemporary relationship experiences also influence trusting intimates and others.     

高性能可重构DSP处理器的数据通路设计

介绍了高性能定点可重构DSP处理器的数据通路设计。该数据通路以功能强大的16位定点计算单元为基础,搭建起高速16位数据处理平台;并能以单指令流多数据流的方式灵活支持多维向量运算;通过重构的方法有效地支持了32位数据处理。     

小波分析在管理数据处理中的应用

提出了一种基于小波变换的管理数据处理方法，把公司管理上的数据看成一个非平稳的时间序列，利用小渡函数将该时间序列分解到不同的频率通道上，然后将分解后的信号当作近似的平稳时间序列，用一些传统的统计方法进行预测，同时对中国足球彩票若干期的销售量数据进行了处理和预测，并将结果与实际销量以及用传统的AR模型的预测值进行了比较。     

档案信息利用服务网络化现状的思考

在社会信息化的趋势下,档案信息化已被高度关注。档案信息利用服务网络化是新形势下档案利用的一种新方式。由于诸多因素的制约,使得基于Internet平台的B S模式的网络利用服务明显滞后。本文从档案信息利用服务网络化的现状、产生的原因及对策三个方面做出分析。