美国与英国公益性科技管理体系研究

从国家科技管理机构、科研体系及公共科研成果转化三个方面分析美国和英国的公益性科技管理制度及其发展变化.随着经济全球化和知识自由流动的发展,科学技术在国家经济发展与社会进步方面的作用越来越大,政府在科技管理上的职能与地位也随之发生变化,总的来说是由原来的主要资助者和实施者转变为催化者和促进者.     

综合文科教育专业人才培养和课程体系的理论研究与教学实践

为适应基础教育改革,开办了综合文科教育专业,在思想政治教育、历史教育和地理教育三个专业进行“主辅修制”改革的基础上,探讨以素质教育为核心,由传统分科教育为主向现代综合教育转变,由专业学科知识为中心向知识整合为中心转变。兼顾初中综合改革发展需要和传统分科教学的现实,培养的学生既能胜任初中综合课程《公民》、《社会》或《人文教育》等的教学,又能适应政治、历史和思想品德等分科课程的教学,还能适应乡镇经济、文化和社会发展需要的新型复合型师资。本文坚持理论研究与实践探索相结合的原则,确定了符合教育规律和实际的综合文科教育专业全新的培养目标和规格,建立了人才培养新模式,构建了全新的教育内容和课程体系。     

基于知识链的管理

论述了知识链的有关概念和特点,通过分析以往的知识链模型,提出了改进的知识链模型;对知识链管理的机制进行了分析;从控制论的角度,对知识链内部知识成长的机制进行了分析,并指出知识链内部知识转移的影响因素,为知识管理的发展提供了一定的理论依据。     

Geometric Method and Generalized Linear Models. Two Opposite Multiparametric Approaches Illustrated on a Sample of Pituitary Adenomas

We used two statistical methods to identify prognostic factors: a log-linear model (logistic and COX regression, based on the notions of linearity and multiplicative relative risk), and the CORICO method (ICOnography of CORrelations) based on the geometric significance of the correlation coefficient. We applied the methods to two different situations (a "case-control study' and a "historical cohort'). We show that the geometric exploratory tool is particularly suited to the analysis of small samples with a large number of variables. It could save time when setting up new study protocols. In this instance, the geometric approach highlighted, without preconceived ideas, the potential role of multihormonality in the course of pituitary adenoma and the unexpected influence of the date of tumour excision on the risk attached to haemorrhage.     

社会转型与先进文化

社会转型为先进化的产生提供了基础，先进化是社会转型成功的客观要求。社会转型决定先进化，先进化又反作用于社会转型。当前中国的快速转型为先进化发挥作用提供了历史舞台，先进化只能服务于建设有中国特色的社会主义的任务，它对当前中国的社会转型起推动作用。发展当代中国的先进化，关键是要从中国先进化的基本内容上搞清楚和把握好主流性、创新性、开放性、先导性、民族性这几个中国先进化建设的重要特点，从而更好地指导当代中国的先进化建设。     

司空图《诗品》篇天人合一思维模式的原型追溯

以原型的方法对司空图《诗品》天人合一思维模式进行了全面分析。指出司空图《诗品》的思维模式遵循了中国古代由诗歌品阶、天时、时律、时历等形成的系统的天人合一模式，是典型的中国思维。     

素质拓展探索——建立数学教学新模式

本文简述建立数学教学新模式的必要性;论述了知识、能力、品质、方法之间的辨证关 系;提出了“知识、能力、品质”相结合的教学模式和一定的方法。     

Statistical Analyses and Modelling of the Mixing Process of Euro Coins in Germany and Europe

This paper reports on the mixing of Euro coins from different countries of origin in Europe, which started on 1 January 2002. There is an interesting conclusion: that the mobility of small and large denominations is different. The long‐term behaviour of the mixing process is studied using a simple deterministic model and data from Germany, France and the Netherlands. The analysis leads to predictions about the future progress of the mixing process.     

高师技法课改革的专业特殊性与科学性

本文从高师技法课(声乐、钢琴)教学改革的大潮中,提出了教学改革中应注意专业的特殊性和科学性,阐述了教学改革应遵循的基本原则以及合理的课型模式。     

Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.