On the maximum number of constraints for s-symbol balanced arrays of strength t

Several upper bounds on the maximum number of constraints for s-symbol balanced arrays of strength t are given. Some bounds derived here include the results obtained by Rafter and Seiden (1974), Chopra (1982, 1983) and Saha, Mukerjee and Kageyama (1983).     

On the analysis of multivariate repeated measures designs

The relationship between the mixed-model analysis and multivariate approach to a repeated measures design with multiple responses is presented. It is shown that by taking the trace of the appropriate submatrix of the hypothesis (error) sums of squares and crossproducts (SSCP) matrix obtained from the multivariate approach, one can get the hypothesis (error) SSCP matrix for the mixed-model analysis. Thus, when analyzing data from a multivariate repeated measures design, it is advantageous to use the multivariate approach because the result of the mixed-model analysis can also be obtained without additional computation.     

De-aliasing effects using semifoldover techniques

Semifoldover designs, obtained by semifolding a regular two-level factorial design, have been discussed recently in the literature. In this article, with the use of indicator functions, we investigate various semifoldover designs that are obtained from a general two-level factorial design. We discuss when a main factor or a two-factor interaction can be de-aliased from their aliased two-factor interactions, and extend some of the existing results from regular designs to non-regular designs. Finally, we present some examples to illustrate the results developed here.     

A study of BIB designs through support matrices

This paper deals with the existence and nonexistence of BIB designs with repeated blocks. The approach is an algebraic one. The concept of a support matrix is introduced and some of its basic properties are noted. Some basic examples of support matrices are given when the block size is 3. The connection between full column rank proper support matrices and irreducible designs is explored and some examples of such matrices are given.     

On the equivalence of two approaches to simplicity in the analysis of block designs and some related results

Two seemingly different approaches to simplicity in the analysis of connected block designs, and their relationship to the concepts of balance are discussed.     

New balanced sampling plans excluding adjacent units

Hedayat et al. [1988a. Sampling plans excluding contiguous units. J. Statist. Plann. Inference 19, 159–170; 1988b. Designs in survey sampling avoiding contiguous units. In: Krishnaiah, P.R., Rao, C.R. (Eds.). Handbook of Statistics, vol. 6. Elsevier, Amsterdam, pp. 575–583] first introduced balanced sampling designs for the exclusion of contiguous units. Sampling plans that excluded the selection of contiguous units within a given sample, while maintaining a constant second-order inclusion probability for non-contiguous units, were investigated for finite populations of N units arranged in a circular, one-dimensional ordering. There remain many open questions about the existence of such plans and their extension to plans excluding adjacent units. We present new generation techniques and new balanced sampling plans for the exclusion of adjacent units under finite, one-dimensional, circularly and linearly ordered populations.     

Comparing search and estimation performances of designs based on a compound criterion

Since the introduction of the search design by Srivastava [Designs for searching non-negligible effects. In: Srivastava, editor. A survey of statistical design and linear models. Amsterdam: North-Holland, Elsevier; 1975. p. 507–519], construction of such designs has been considered by many researchers. The efficient performances of constructed search designs in terms of parameter estimation and search ability of parameters have also been investigated by several authors. They have proposed suitable optimality measures such as DD- and AD-optimality for estimation in the early stage of search design construction. Moreover, since 1990s, some criteria have been developed to evaluate search performance of a design. Although these criteria are useful none of them is able to evaluate both estimation and search efficiency of a design simultaneously. In this paper, we propose dual-task criteria to deal with searching and estimating performances of search designs. These compound criteria are weighted multiplication of estimation and search suitable criteria. They will be used for design comparison and the results will be presented.     

Three-stage designs for monitoring clinical trials

Optimal three-stage designs with equal sample sizes at each stage are presented and compared to fixed sample designs, fully sequential designs, designs restricted to use the fixed sample critical value at the final stage, and to modifications of other group sequential designs previously proposed in the literature. Typically, the greatest savings realized with interim analyses are obtained by the first interim look. More than 50% of the savings possible with a fully sequential design can be realized with a simple two-stage design. Three-stage designs can realize as much as 75% of the possible savings. Without much loss in efficiency, the designs can be modified so that the critical value at the final stage equals the usual fixed sample value while maintaining the overall level of significance, alleviating some potential confusion should a final stage be necessary. Some common group sequential designs, modified to allow early acceptance of the null hypothesis, are shown to be nearly optimal in some settings while performing poorly in others. An example is given to illustrate the use of several three-stage plans in the design of clinical trials.     

(M,S)-optimal row-column designs

Row-column designs may be considered to have two blocking schemes, namely the treatments by rows and treatments by columns component block designs. The (M,S)-optimality criterion is applied to row-column designs, and che connection between the (M,S)-optimal design and its component block designs is demonstrated.