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I consider the design of multistage sampling schemes for epidemiologic studies involving latent variable models, with surrogate measurements of the latent variables on a subset of subjects. Such models arise in various situations: when detailed exposure measurements are combined with variables that can be used to assign exposures to unmeasured subjects; when biomarkers are obtained to assess an unobserved pathophysiologic process; or when additional information is to be obtained on confounding or modifying variables. In such situations, it may be possible to stratify the subsample on data available for all subjects in the main study, such as outcomes, exposure predictors, or geographic locations. Three circumstances where analytic calculations of the optimal design are possible are considered: (i) when all variables are binary; (ii) when all are normally distributed; and (iii) when the latent variable and its measurement are normally distributed, but the outcome is binary. In each of these cases, it is often possible to considerably improve the cost efficiency of the design by appropriate selection of the sampling fractions. More complex situations arise when the data are spatially distributed: the spatial correlation can be exploited to improve exposure assignment for unmeasured locations using available measurements on neighboring locations; some approaches for informative selection of the measurement sample using location and/or exposure predictor data are considered.  相似文献   
13.
For semiparametric models, interval estimation and hypothesis testing based on the information matrix for the full model is a challenge because of potentially unlimited dimension. Use of the profile information matrix for a small set of parameters of interest is an appealing alternative. Existing approaches for the estimation of the profile information matrix are either subject to the curse of dimensionality, or are ad-hoc and approximate and can be unstable and numerically inefficient. We propose a numerically stable and efficient algorithm that delivers an exact observed profile information matrix for regression coefficients for the class of Nonlinear Transformation Models [A. Tsodikov (2003) J R Statist Soc Ser B 65:759-774]. The algorithm deals with the curse of dimensionality and requires neither large matrix inverses nor explicit expressions for the profile surface.  相似文献   
14.
Finding optimal, or at least good, maintenance and repair policies is crucial in reliability engineering. Likewise, describing life phases of human mortality is important when determining social policy or insurance premiums. In these tasks, one searches for distributions to fit data and then makes inferences about the population(s). In the present paper, we focus on bathtub‐type distributions and provide a view of certain problems, methods and solutions, and a few challenges, that can be encountered in reliability engineering, survival analysis, demography and actuarial science.  相似文献   
15.
一种基于加权F-范数的半正定矩阵的逼近方法   总被引:1,自引:0,他引:1  
正定性是许多金融预测模型的重要假设前提,然而从实际样本中得到的相关系数矩阵并不能保证其正定性。为此在介绍如何根据样本设定相关系数矩阵以及范数逼近原理的基础上,如何根据该原理找到与之最接近的相关系数矩阵,即最接近的单位对角半正定对称矩阵。通过实证,验证了其方法的有效性。  相似文献   
16.
中国交通运输业发展的实证研究   总被引:1,自引:0,他引:1  
采用协整和误差纠正模型与方法,对中国改革开放20多年来交通运输发展与一些相关影响因素之间的关系进行实证研究。结果表明:旅客运输需求与国民收入、乘车费用之间,货物运输与国民经济、燃油价格之间分别存在长期稳定关系。研究认为:中国交通的发展应适当超前于国民经济的发展。同时,研究还发现:“旅游黄金周”的实施并不是促进中国旅客运输需求的显著影响因素。  相似文献   
17.
It is well known that two-phase (or double) sampling is of significant use in practice when the population parameter(s) (say, population mean X¯) of the auxiliary variate x is not known. Keeping this in view, we have suggested a class of ratio-product estimators in two-phase sampling with its properties. The asymptotically optimum estimators (AOEs) in the class are identified in two different cases with their variances. Conditions for the proposed estimator to be more efficient than the two-phase sampling ratio, product and mean per unit estimator are investigated. Comparison with single phase sampling is also discussed. An empirical study is carried out to demonstrate the efficiency of the suggested estimator over conventional estimators.  相似文献   
18.
Standard methods of estimation for autoregressive models are known to be biased in finite samples, which has implications for estimation, hypothesis testing, confidence interval construction and forecasting. Three methods of bias reduction are considered here: first-order bias correction, FOBC, where the total bias is approximated by the O(T-1) bias; bootstrapping; and recursive mean adjustment, RMA. In addition, we show how first-order bias correction is related to linear bias correction. The practically important case where the AR model includes an unknown linear trend is considered in detail. The fidelity of nominal to actual coverage of confidence intervals is also assessed. A simulation study covers the AR(1) model and a number of extensions based on the empirical AR(p) models fitted by Nelson & Plosser (1982). Overall, which method dominates depends on the criterion adopted: bootstrapping tends to be the best at reducing bias, recursive mean adjustment is best at reducing mean squared error, whilst FOBC does particularly well in maintaining the fidelity of confidence intervals.  相似文献   
19.
提出了一套系统方法用于求解任意导体片位于界面的Chiral分层媒质的谐振频率,衰减因子和电磁场分布。文中的分析是在Fourier变换域的并矢格林函数和矩阵分析的基础上来进行的,给出的公式的最大价值在于它提供了求解Chiral分层媒质问题的方法论。  相似文献   
20.
本文提出了圆锥轴受扭时静、动力的传递矩阵。该方法简便实用,适于工程技术人员在微机上应用。  相似文献   
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