Assessing Effects on Long-term Survival after Early Termination of Randomized Trials

In this paper we present an approach to using historical control data to augment information from a randomized controlled clinical trial, when it is not possible to continue the control regimen to obtain the most reliable and valid assessment of long term treatment effects. Using an adjustment procedure to the historical control data, we investigate a method of estimating the long term survival function for the clinical trial control group and for evaluating the long term treatment effect. The suggested method is simple to interpret, and particularly motivated in clinical trial settings when ethical considerations preclude the long term follow-up of placebo controls. A simulation study reveals that the bias in parameter estimates that arises in the setting of group sequential monitoring will be attenuated when long term historical control information is used in the proposed manner. Data from the first and second National Wilms' Tumor studies are used to illustrate the method.     

Kernel Density Estimation with Generalized Binning

We propose kernel density estimators based on prebinned data. We use generalized binning schemes based on the quantiles points of a certain auxiliary distribution function. Therein the uniform distribution corresponds to usual binning. The statistical accuracy of the resulting kernel estimators is studied, i.e. we derive mean squared error results for the closeness of these estimators to both the true function and the kernel estimator based on the original data set. Our results show the influence of the choice of the auxiliary density on the binned kernel estimators and they reveal that non-uniform binning can be worthwhile.     

Beta-Bernstein Smoothing for Regression Curves with Compact Support

ABSTRACT. The problem of boundary bias is associated with kernel estimation for regression curves with compact support. This paper proposes a simple and uni(r)ed approach for remedying boundary bias in non-parametric regression, without dividing the compact support into interior and boundary areas and without applying explicitly different smoothing treatments separately. The approach uses the beta family of density functions as kernels. The shapes of the kernels vary according to the position where the curve estimate is made. Theyare symmetric at the middle of the support interval, and become more and more asymmetric nearer the boundary points. The kernels never put any weight outside the data support interval, and thus avoid boundary bias. The method is a generalization of classical Bernstein polynomials, one of the earliest methods of statistical smoothing. The proposed estimator has optimal mean integrated squared error at an order of magnitude n ^−4/5, equivalent to that of standard kernel estimators when the curve has an unbounded support.     

Non-parametric estimation of the long-range dependence exponent for Gaussian processes

We consider a class of long-range-dependent Gaussian processes defined in a semiparametric framework. We propose a new estimator of the long-range dependence parameter, based on the integration of the periodogram in two windows. We show that it is asymptotically Gaussian and calculate the rate of convergence. We optimise parameters defining the window function for the minimum mean-square-error criterion. In a Monte-Carlo study, we compare the proposed estimator with previously studied estimators.     

人机工程学的发展及人机系统的可靠性

本文介绍了人机工程学(工效学)这一新兴边缘学科的研究内容、发展及现状,讨论了人-机系统的可靠性并着重讨论了人的操作可靠性,探讨了按人为差错进行可靠性分析与可靠性估计的人为差错和可靠性分析逻辑推演法(HERALD法)及系统能力方法(SC方法)。 本文的结论可供系统管理工作者及设计工作者,特别是可靠性管理及可靠性设计工作者参考。     

Out-of-sample forecast errors in misspecific perturbed long memory processes

In this paper we examine the relative increase in mean square forecast error fro fitting a weakly stationary process to the series of interest when in fact the true model is a so-called perturbed long-memory process recently introduced by Granger and Marmol (1997). This model has the property of being unidentifiable from a white noise process on the basis of the correlogram and the usual rule-of-thumbs in the Box-Jenkins methodology. We prove that this kind of missspecification can lead to serious errors in terms of forecasting. We also show that corrections based on the AR(1) model can in some cases partially solve the problem. Received: March 15, 1999; revised version: February 14, 2000     

Book Reviews

Books reviewed:
Philip Hans Franses & Dick van Dijk, Non-linear Time Series Models in Empirical Finance
Herbert Spirer, Louise Spirer & A.J. Jaffe, Misused Statistics
Deborah J. Bennett, Randomness
C.E. Linneborg, Data Analysis by Resampling: Concepts and Applications
I. Clark and W.V. Harper, Practical Geostatistics 2000     

Overcoming biases and misconceptions in ecological studies

The aggregate data study design provides an alternative group level analysis to ecological studies in the estimation of individual level health risks. An aggregate model is derived by aggregating a plausible individual level relative rate model within groups, such that population-based disease rates are modelled as functions of individual level covariate data. We apply an aggregate data method to a series of fictitious examples from a review paper by Greenland and Robins which illustrated the problems that can arise when using the results of ecological studies to make inference about individual health risks. We use simulated data based on their examples to demonstrate that the aggregate data approach can address many of the sources of bias that are inherent in typical ecological analyses, even though the limited between-region covariate variation in these examples reduces the efficiency of the aggregate study. The aggregate method has the potential to estimate exposure effects of interest in the presence of non-linearity, confounding at individual and group levels, effect modification, classical measurement error in the exposure and non-differential misclassification in the confounder.     

Error rates in classification consisting of discrete and continuous variables in the presence of covariates

We consider classifying an object based on mixed continuous and discrete variables between two populations. Mixed discrete and continuous covariates with identical means in both populations are amongst the variables. Under the location model with homogeneous location specific conditional dispersion matrices for both populations, the Bayes rule is given. Classification is implemented by a plug-in version of the Bayes rule with full covariate adjustment. An asymptotic expansion of the overall expected error of the procedure is derived. Our findings generalize several classical results.     

Statistical inference for partially time-varying coefficient errors-in-variables models

This paper studies the partially time-varying coefficient models where some covariates are measured with additive errors. In order to overcome the bias of the usual profile least squares estimation when measurement errors are ignored, we propose a modified profile least squares estimator of the regression parameter and construct estimators of the nonlinear coefficient function and error variance. The proposed three estimators are proved to be asymptotically normal under mild conditions. In addition, we introduce the profile likelihood ratio test and then demonstrate that it follows an asymptotically χ²${\chi }^2$ distribution under the null hypothesis. Finite sample behavior of the estimators is investigated via simulations too.