Reference‐based sensitivity analysis for time‐to‐event data

The analysis of time‐to‐event data typically makes the censoring at random assumption, ie, that—conditional on covariates in the model—the distribution of event times is the same, whether they are observed or unobserved (ie, right censored). When patients who remain in follow‐up stay on their assigned treatment, then analysis under this assumption broadly addresses the de jure, or “while on treatment strategy” estimand. In such cases, we may well wish to explore the robustness of our inference to more pragmatic, de facto or “treatment policy strategy,” assumptions about the behaviour of patients post‐censoring. This is particularly the case when censoring occurs because patients change, or revert, to the usual (ie, reference) standard of care. Recent work has shown how such questions can be addressed for trials with continuous outcome data and longitudinal follow‐up, using reference‐based multiple imputation. For example, patients in the active arm may have their missing data imputed assuming they reverted to the control (ie, reference) intervention on withdrawal. Reference‐based imputation has two advantages: (a) it avoids the user specifying numerous parameters describing the distribution of patients' postwithdrawal data and (b) it is, to a good approximation, information anchored, so that the proportion of information lost due to missing data under the primary analysis is held constant across the sensitivity analyses. In this article, we build on recent work in the survival context, proposing a class of reference‐based assumptions appropriate for time‐to‐event data. We report a simulation study exploring the extent to which the multiple imputation estimator (using Rubin's variance formula) is information anchored in this setting and then illustrate the approach by reanalysing data from a randomized trial, which compared medical therapy with angioplasty for patients presenting with angina.     

城市社会公德缺失问题及对策

在城市伦理视阈下,从人与人、人与社会、人与自然之间的关系,列举了社会公德缺失现状;从封建传统社会、现代社会、社会公德自身特点及建设难点3个方面,分析了社会公德缺失产生的原因;从培育公德意识、加强法制化建设和培养公德精神3个方面提出了解决城市社会公德缺失问题的对策。     

网络学习中文化传统的缺失

经济的全球化引发对文化传统的反思,文化传统是民族精神,是民族共同的心理状态。网络的虚拟性背离了民族魂的核心———真、善、美、诚信;浮躁心理引发道德信仰的危机;追逐时尚使传统价值观变成商品而被贬值;数字化推进着传统技艺的匮竭。文化传统的缺失正在动摇着中华民族安身立命的精神家园。     

Estimation of regression parameters in missing data problems

Let Y be a response variable, possibly multivariate, with a density function f (y|x, v; β) conditional on vectors x and v of covariates and a vector β of unknown parameters. The authors consider the problem of estimating β when the values taken by the covariate vector v are available for all observations while some of those taken by the covariate x are missing at random. They compare the profile estimator to several alternatives, both in terms of bias and standard deviation, when the response and covariates are discrete or continuous.     

Working With Missing Values

Less than optimum strategies for missing values can produce biased estimates, distorted statistical power, and invalid conclusions. After reviewing traditional approaches (listwise, pairwise, and mean substitution), selected alternatives are covered including single imputation, multiple imputation, and full information maximum likelihood estimation. The effects of missing values are illustrated for a linear model, and a series of recommendations is provided. When missing values cannot be avoided, multiple imputation and full information methods offer substantial improvements over traditional approaches. Selected results using SPSS, NORM, Stata (mvis/micombine), and Mplus are included as is a table of available software and an appendix with examples of programs for Stata and Mplus.     

A kernel smoothing method of adjusting for unit non‐response in sample surveys

Non‐response is a common problem in survey sampling and this phenomenon can only be ignored at the risk of invalidating inferences from a survey. In order to adjust for unit non‐response, the authors propose a weighting method in which kernel regression is used to estimate the response probabilities. They show that the adjusted estimator is consistent and they derive its asymptotic distribution. They also suggest a means of estimating its variance through a replication‐based technique. Furthermore, a Monte Carlo study allows them to illustrate the properties of the non‐response adjustment and its variance estimator.     

数据分析中的数据质量识别

数据的质量直接影响数据分析的效率和分析结果的可靠性。数据质量包括数据结构质量和给定数据结构后的数据真实性、一致性和完整性。在着重考虑拿到数据之后,从单元格、记录、变量三个角度如何识别数据中潜在的质量问题,并以案例为支撑,介绍了各种可能出现的问题。     

ESTIMATION IN RICKER'S TWO-RELEASE METHOD: A BAYESIAN APPROACH

The Ricker's two‐release method is a simplified version of the Jolly‐Seber method, from Seber's Estimation of Animal Abundance (1982) , used to estimate survival rate and abundance in animal populations. This method assumes there is only a single recapture sample and no immigration, emigration or recruitment. In this paper, we propose a Bayesian analysis for this method to estimate the survival rate and the capture probability, employing Markov chain Monte Carlo methods and a latent variable analysis. The performance of the proposed method is illustrated with a simulation study as well as a real data set. The results show that the proposed method provides favourable inference for the survival rate when compared with the modified maximum likelihood method.     

Rate/Mean Regression for Multiple-Sequence Recurrent Event Data with Missing Event Category

Abstract.  Censored recurrent event data frequently arise in biomedical studies. Often, the events are not homogenous, and may be categorized. We propose semiparametric regression methods for analysing multiple-category recurrent event data and consider the setting where event times are always known, but the information used to categorize events may be missing. Application of existing methods after censoring events of unknown category (i.e. 'complete-case' methods) produces consistent estimators only when event types are missing completely at random, an assumption which will frequently fail in practice. We propose methods, based on weighted estimating equations, which are applicable when event category missingness is missing at random. Parameter estimators are shown to be consistent and asymptotically normal. Finite sample properties are examined through simulations and the proposed methods are applied to an end-stage renal disease data set obtained from a national organ failure registry.