Akaike Information Criterion for Selecting Variables in the Nested Error Regression Model

The Akaike Information Criterion (AIC) is developed for selecting the variables of the nested error regression model where an unobservable random effect is present. Using the idea of decomposing the likelihood into two parts of “within” and “between” analysis of variance, we derive the AIC when the number of groups is large and the ratio of the variances of the random effects and the random errors is an unknown parameter. The proposed AIC is compared, using simulation, with Mallows' C _p , Akaike's AIC, and Sugiura's exact AIC. Based on the rates of selecting the true model, it is shown that the proposed AIC performs better.     

Computer-Generated Change-Over Designs for Correlated Observations

Change-over designs with independently distributed errors in the model have been studied extensively in the literature. Martin and Eccleston (2001 Martin , R. J. , Eccleston , J. A. ( 2001 ). Optimal and near optimal designs for dependent observations . Statist. Applic. 3 : 101 – 116 . [Google Scholar]) gave an algorithm for the generation of efficient change-over designs when the errors are correlated. This article proposes an algorithm for the generation of efficient change-over designs for estimation of direct effects of treatments in the presence of first-order residual effects in the model and when the errors are correlated.     

Diagnostic tests for the distribution of random effects in multivariate mixed effects models

Abstract

Fourier methods are proposed for testing the distribution of random effects in classical and robust multivariate mixed effects models. The test statistics involve estimation of the characteristic function of random effects. Theoretical and computational issues are addressed while Monte Carlo results show that the new procedures compare favorably with other methods.     

A variance shift model for detection of outliers in the linear mixed measurement error models

ABSTRACT

In this paper, we extend a variance shift model, previously considered in the linear mixed models, to the linear mixed measurement error models using the corrected likelihood of Nakamura (1990 Nakamura, T. (1990). Corrected score function for errors in variables models: methodology and application to generalized linear models. Biometrika 77:127–137.[Crossref], [Web of Science ®] , [Google Scholar]). This model assumes that a single outlier arises from an observation with inflated variance. We derive the score test and the analogue of the likelihood ratio test, to assess whether the ith observation has inflated variance. A parametric bootstrap procedure is implemented to obtain empirical distributions of the test statistics. Finally, results of a simulation study and an example of real data are presented to illustrate the performance of proposed tests.     

Modeling of covariance structures of random effects and random errors in linear mixed models

Abstract

In this paper, we discuss how to model the mean and covariancestructures in linear mixed models (LMMs) simultaneously. We propose a data-driven method to modelcovariance structures of the random effects and random errors in the LMMs. Parameter estimation in the mean and covariances is considered by using EM algorithm, and standard errors of the parameter estimates are calculated through Louis’ (1982 Louis, T.A. (1982). Finding observed information using the EM algorithm. J. Royal Stat. Soc. B 44:98–130. [Google Scholar]) information principle. Kenward’s (1987 Kenward, M.G. (1987). A method for comparing profiles of repeated measurements. Appl. Stat. 36:296–308.[Crossref], [Web of Science ®] , [Google Scholar]) cattle data sets are analyzed for illustration,and comparison to the literature work is made through simulation studies. Our numerical analysis confirms the superiority of the proposed method to existing approaches in terms of Akaike information criterion.     

A comparison of three methods of estimating the logistic regression coefficients

A Sampling experiment performed using data collected for a large clinical trial shows that the discriminant function estimates of the logistic regression coefficients for discrete variables may be severely biased. The simulations show that the mixed variable location model coefficient estimates have bias which is of the same magnitude as the bias in the coefficient estimates obtained using conditional maximum likelihood estimates but require about one-tenth of the computer time.     

Optimal allocation of time points for the random effects model

In this article the problem of the optimal selection and allocation of time points in repeated measures experiments is considered. D‐ optimal designs for linear regression models with a random intercept and first order auto‐regressive serial correlations are computed numerically and compared with designs having equally spaced time points. When the order of the polynomial is known and the serial correlations are not too small, the comparison shows that for any fixed number of repeated measures, a design with equally spaced time points is almost as efficient as the D‐ optimal design. When, however, there is no prior knowledge about the order of the underlying polynomial, the best choice in terms of efficiency is a D‐ optimal design for the highest possible relevant order of the polynomial. A design with equally‐spaced time points is the second best choice     

Generalized additive mixed models

Following the extension from linear mixed models to additive mixed models, extension from generalized linear mixed models to generalized additive mixed models is made, Algorithms are developed to compute the MLE's of the nonlinear effects and the covariance structures based on the penalized marginal likelihood. Convergence of the algorithms and selection of the smooth param¬eters are discussed.     

A boundary kernel for local polynomial regression

We define and compute a boundary kernel for local polynomial regression, We prove that the new kernel provides improvement over the existing kernels, Simulations show the improvement in finite samples.     

Likelihood-Based Inference for Multivariate Skew-Normal Regression Models

In this article, we present EM algorithms for performing maximum likelihood estimation for three multivariate skew-normal regression models of considerable practical interest. We also consider the restricted estimation of the parameters of certain important special cases of two models. The methodology developed is applied in the analysis of longitudinal data on dental plaque and cholesterol levels.