Geometric Method and Generalized Linear Models. Two Opposite Multiparametric Approaches Illustrated on a Sample of Pituitary Adenomas

We used two statistical methods to identify prognostic factors: a log-linear model (logistic and COX regression, based on the notions of linearity and multiplicative relative risk), and the CORICO method (ICOnography of CORrelations) based on the geometric significance of the correlation coefficient. We applied the methods to two different situations (a "case-control study' and a "historical cohort'). We show that the geometric exploratory tool is particularly suited to the analysis of small samples with a large number of variables. It could save time when setting up new study protocols. In this instance, the geometric approach highlighted, without preconceived ideas, the potential role of multihormonality in the course of pituitary adenoma and the unexpected influence of the date of tumour excision on the risk attached to haemorrhage.     

Herd behavior and the quality of opinions

This paper analyzes a decentralized decision model by adding some inertia in the social leaning process. Before making a decision, an agent can observe the group opinion in a society. Social learning can result in a variety of equilibrium behavioral patterns. For insufficient ranges of quality (precision) of opinions, the chosen stationary state is unique and globally accessible, in which all agents adopt the superior action. Sufficient quality of opinions gives rise to multiple stationary states. One of them will be characterized by inefficient herding. The confidence in the majority opinion then has serious welfare consequences.     

世界经济增速下滑与中国经济持续快速增长

世界经济增速下滑对我国经济虽有严重的不利影响 ,但只要我们坚持扩大内需的方针 ,继续实施积极的财政政策和稳健的货币政策 ,大力调整经济结构 ,进一步提高对外开放水平 ,深化经济体制改革 ,中国经济就能保持持续快速健康发展     

司空图《诗品》篇天人合一思维模式的原型追溯

以原型的方法对司空图《诗品》天人合一思维模式进行了全面分析。指出司空图《诗品》的思维模式遵循了中国古代由诗歌品阶、天时、时律、时历等形成的系统的天人合一模式，是典型的中国思维。     

素质拓展探索——建立数学教学新模式

本文简述建立数学教学新模式的必要性;论述了知识、能力、品质、方法之间的辨证关 系;提出了“知识、能力、品质”相结合的教学模式和一定的方法。     

Statistical Analyses and Modelling of the Mixing Process of Euro Coins in Germany and Europe

This paper reports on the mixing of Euro coins from different countries of origin in Europe, which started on 1 January 2002. There is an interesting conclusion: that the mobility of small and large denominations is different. The long‐term behaviour of the mixing process is studied using a simple deterministic model and data from Germany, France and the Netherlands. The analysis leads to predictions about the future progress of the mixing process.     

工厂供电课程教学方法探讨

工厂供电课程存在着教学任务肾、课时少的现象,按传统的讲授法进行教学,会出现教不好、学不透的两难境地。为避免此类现象的发生,提出了引导法、角色转换法、对比论证法、现代教育法等多种教学方法。经过教学实践证明,这些方法能有效地提高学生的学习效率,促进学生综合能力的提高。     

高师技法课改革的专业特殊性与科学性

本文从高师技法课(声乐、钢琴)教学改革的大潮中,提出了教学改革中应注意专业的特殊性和科学性,阐述了教学改革应遵循的基本原则以及合理的课型模式。     

Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

论我国外贸代理制度的完善

从20世纪80年代起施行的我国外贸代理制度,在制度设计和实践操作上都存在着较大缺陷。本文以WTO对我国外贸代理制度的要求为指针,认为应采取转变对外贸代理制度的认识、整合外贸代理立法、改革我国外贸经营权制度等措施,完善我国的外贸代理制度,使其与国际商事规则接轨。