Hypothesis Testing Problems in an Unbalanced Longitudinal Ophthalmology Study

ABSTRACT

The analysis of clustered data in a longitudinal ophthalmology study is complicated by correlations between repeatedly measured visual outcomes of paired eyes in a participant and missing observations due to the loss of follow-up. In the present article we consider hypothesis testing problems in an ophthalmology study, where eligible eyes are randomized to two treatments (when two eyes of a participant are eligible, the paired eyes are assigned to different treatments), and vision function outcomes are repeatedly measured over time. A large sample-based nonparametric test statistic and a nonparametric Bootstrap test analog are proposed for testing an interaction effect of two factors and testing an effect of a eye-specific factor within a level of the other person-specific factor on visual function outcomes. Both test statistics allow for missing observations, correlations between repeatedly measured outcomes on individual eyes, and correlations between repeatedly measured outcomes on both eyes of each participant. A simulation study shows that these proposed test statistics maintain nominal significance levels approximately and comparable powers to each other, as well as higher powers than the naive test statistic ignoring correlations between repeated bilateral measurements of both eyes in the same person. For illustration, we apply the proposed test statistics to the changes of visual field defect score in the Advanced Glaucoma Intervention Study.     

Estimators for the Finite Mixture of Rayleigh Model Based on Progressively Censored Data

In this article, based on progressively Type-II censored samples from a heterogeneous population that can be represented by a finite mixture of two-component Rayleigh lifetime model, the problem of estimating the parameters and some lifetime parameters (reliability and hazard functions) are considered. Both Bayesian and maximum likelihood estimators are of interest. A class of natural conjugate prior densities is considered in the Bayesian setting. The Bayes estimators are obtained using both the symmetric (squared error) loss function, and the asymmetric (LINEX and General Entropy) loss functions. It has been seen that the estimators obtained can be easily evaluated for this type of censoring by using suitable numerical methods. Finally, the performance of the estimates have been compared on the basis of their simulated maximum square error via a Monte Carlo simulation study.     

A Note on Influence Assessment in Score Tests

Recently, [1] Ebrahimi, N. 1996. How to measure uncertainty about residual life time. Sankhya Ser. A, 58: 48–57.  [Google Scholar] proposed a dynamic measure based on differential entropy applied to the residual lifetime. This measure has been used for the classification and ordering of survival functions. More recently, [2] Ebrahimi, N. 1997. Testing whether lifetime distribution is decreasing uncertainty. Journal of Statistical Planning and Inference, 64: 9–19. [Crossref], [Web of Science ®] , [Google Scholar] has considered the problem of testing the monotonicity of this measure. We propose and study several kernel type estimators of the entropy of residual life through the estimation of f(x) log f(x). These estimators can be applied to the classification and comparison of lifetime distribution.     

Combining Univariate Tests for Multivariate Location Problem

In this article, three methods of combining dependent univariate tests are studied. The Bahadur approximate efficiencies are derived under the asymptotic normal assumption. These procedures are applied to the multivariate location problem and compared with two Hotelling-type tests. A Monte Carlo study indicates that in certain cases the powers of the combination methods are much better than Hotelling's T ² and other multivariate nonparametric tests.     

Admissibility of Test Procedures for Linear Hypotheses in General Linear Model

This article shows that an F-test procedure is admissible for testing a linear hypothesis concerning one of the split mean vectors in a general linear model and an F-test procedure is also admissible for testing a linear hypothesis concerning another of the split mean vectors in the same model. These results are proved by showing that the critical functions of the tests are unique Bayes procedures with respect to proper prior distributions set in common for the null hypotheses and for the alternative ones, respectively.     

Bayes Prediction for a Heteroscedastic Regression Superpopulation Model Using Balanced Loss Function

We consider Prais–Houthakker heteroscedastic normal regression model having variance of the dependent variable same as square of its expectation. Bayes predictors for the regression coefficient and the mean of a finite population are derived using Zellner's balanced loss function. Bayes predictive expected losses are obtained and compared with those of classical predictors and Bayes predictors under squared error loss function to examine their loss robustness.     

Marshall–Olkin Extended Lomax Distribution and Its Application to Censored Data

The problem of making statistical inference about θ =P(X > Y) has been under great investigation in the literature using simple random sampling (SRS) data. This problem arises naturally in the area of reliability for a system with strength X and stress Y. In this study, we will consider making statistical inference about θ using ranked set sampling (RSS) data. Several estimators are proposed to estimate θ using RSS. The properties of these estimators are investigated and compared with known estimators based on simple random sample (SRS) data. The proposed estimators based on RSS dominate those based on SRS. A motivated example using real data set is given to illustrate the computation of the newly suggested estimators.     

Pseudo New Modified Latin Square (NML m (m)) Type PBIB Designs

A New Modified Latin square [NML _i (m)] association scheme with i constraints for v = m ² treatments was introduced by Garg (2008 Garg , D. K. ( 2008 ). New modified Latin square (NMLi) type PBIB designs . J. Math. Syst. Sci. 1 ( 4 ): 83 – 89 . [Google Scholar]). In this article, a new association scheme known as Pseudo New Modified Latin square [Pseudo NML _m (m)] type association scheme is defined. The parameters of Pseudo NML _m (m) association scheme turned out to be parameters of NML _i (m) association scheme by taking i = m in NML _i (m) association scheme. The Pseudo NML _m (m) association scheme will be the usual NML _m (m) association scheme when m is a prime or a prime power. The PBIB designs following Pseudo NML _m (m) association scheme will be called the Pseudo NML _m (m) type PBIB designs. Analysis of Pseudo NML _m (m) designs along with a construction method of these designs is also given in this article.     

Detection and Interpretation of a Multivariate Signal Using Combined Charts

A control procedure is presented in this article that is based on jointly using two separate control statistics in the detection and interpretation of signals in a multivariate normal process. The procedure detects the following three situations: (i) a mean vector shift without a shift in the covariance matrix; (ii) a shift in process variation (covariance matrix) without a mean vector shift; and (iii) both a simultaneous shift in the mean vector and covariance matrix as the result of a change in the parameters of some key process variables. It is shown that, following the occurrence of a signal on either of the separate control charts, the values from both of the corresponding signaling statistics can be decomposed into interpretable elements. Viewing the two decompositions together helps one to specifically identify the individual components and associated variables that are being affected. These components may include individual means or variances of the process variables as well as the correlations between or among variables. An industrial data set is used to illustrate the procedure.