Testing parallelism of regression lines against ordered alternatives

For the problem of testing the equality of slopes of several regression lines against the alternative that the slopes are in increasing (decreasing) order of magnitude, two types of tests are proposed. These are the likelihood ratio test and a test that depends on suitable linear combination of one group statistics. Rank analogues of the two tests are also examined.     

Prediction Techniques for Box–Cox Regression Models

This article reviews several techniques useful for forming point and interval predictions in regression models with Box-Cox transformed variables. The techniques reviewed—plug-in, mean squared error analysis, predictive likelihood, and stochastic simulation—take account of nonnormality and parameter uncertainty in varying degrees. A Monte Carlo study examining their small-sample accuracy indicates that uncertainty about the Box–Cox transformation parameter may be relatively unimportant. For certain parameters, deterministic point predictions are biased, and plug-in prediction intervals are also biased. Stochastic simulation, as usually carried out, leads to badly biased predictions. A modification of the usual approach renders stochastic simulation predictions largely unbiased.     

Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

Gaining insight with recursive partitioning of generalized linear models

Recursive partitioning algorithms separate a feature space into a set of disjoint rectangles. Then, usually, a constant in every partition is fitted. While this is a simple and intuitive approach, it may still lack interpretability as to how a specific relationship between dependent and independent variables may look. Or it may be that a certain model is assumed or of interest and there is a number of candidate variables that may non-linearly give rise to different model parameter values. We present an approach that combines generalized linear models (GLM) with recursive partitioning that offers enhanced interpretability of classical trees as well as providing an explorative way to assess a candidate variable's influence on a parametric model. This method conducts recursive partitioning of a GLM by (1) fitting the model to the data set, (2) testing for parameter instability over a set of partitioning variables, (3) splitting the data set with respect to the variable associated with the highest instability. The outcome is a tree where each terminal node is associated with a GLM. We will show the method's versatility and suitability to gain additional insight into the relationship of dependent and independent variables by two examples, modelling voting behaviour and a failure model for debt amortization, and compare it to alternative approaches.     

Approximate Bayes estimation of the parameters and reliability function of a mixture of two inverse Weibull distributions under Type-2 censoring

The main goal of this paper is to develop the approximate Bayes estimation of the five-dimensional vector of the parameters and reliability function of a mixture of two inverse Weibull distributions (MTIWD) under Type-2 censoring. Usually, the posterior distribution is complicated under the scheme of Type-2 censoring and the integrals that are involved cannot be obtained in a simple explicit form. In this study, we use Lindley's [Approximate Bayesian method, Trabajos Estadist. 31 (1980), pp. 223–237] approximate form of Bayes estimation in the case of an MTIWD under Type-2 censoring. Later, we calculate the estimated risks (ERs) of the Bayes estimates and compare them with the corresponding ERs of the maximum-likelihood estimates through Monte Carlo simulation. Finally, we analyse a real data set using the findings.     

A consistent method of estimation for the parameters of the three-parameter inverse Gaussian distribution

In this paper, we propose a consistent method of estimation for the parameters of the three-parameter inverse Gaussian distribution. We then discuss some properties of these estimators and show by means of a Monte Carlo simulation study that the proposed estimators perform better than some other prominent estimators in terms of bias and root mean squared error. Finally, we present two real-life examples to illustrate the method of inference developed here.     

Semiparametric ROC surface estimation for continuous diagnostic tests via polytomous logistic regression procedures

In this paper, we propose a semiparametric method of estimating receiver operating characteristic (ROC) surfaces for continuous diagnostic tests under density ratio models. Implementation of our method is easy since the usual polytomous logistic regression procedures in many statistical software packages can be employed. A simulated example is provided to facilitate the implementation of our method. Simulation results show that the proposed semiparametric ROC surface estimator is more efficient than the nonparametric counterpart and the parametric counterpart whether the normality assumption of data holds or not. Moreover, some simulation results on the underlying semiparametric distribution function estimators are also reported. In addition, some discussions on the proposed method as well as analysis of a real data set are provided.     

An Empirical Likelihood Ratio Test for Normality

The empirical likelihood ratio (ELR) test for the problem of testing for normality is derived in this article. The sampling properties of the ELR test and four other commonly used tests are provided and analyzed using the Monte Carlo simulation technique. The power comparisons against a wide range of alternative distributions show that the ELR test is the most powerful of these tests in certain situations.     

Estimation of the Proportion of Defective Units by Using Group Testing Under the Existence of a Threshold of Detection

Group testing procedures, in which groups containing several units are tested without testing each unit, are widely used as cost-effective procedures in estimating the proportion of defective units in a population. A problem arises when we apply these procedures to the detection of genetically modified organisms (GMOs), because the analytical instrument for detecting GMOs has a threshold of detection. If the group size (i.e., the number of units within a group) is large, the GMOs in a group are not detected due to the dilution even if the group contains one unit of GMOs. Thus, most people conventionally use a small group size (which we call conventional group size) so that they can surely detect the existence of defective units if at least one unit of GMOs is included in the group. However, we show that we can estimate the proportion of defective units for any group size even if a threshold of detection exists; the estimate of the proportion of defective units is easily obtained by using functions implemented in a spreadsheet. Then, we show that the conventional group size is not always optimal in controlling a consumer's risk, because such a group size requires a larger number of groups for testing.     

Robust Correlation Structure for Multivariate Failure Time Data

When incomplete repeated failure times are collected from a large number of independent individuals, interest is focused primarily on the consistent and efficient estimation of the effects of the associated covariates on the failure times. Since repeated failure times are likely to be correlated, it is important to exploit the correlation structure of the failure data in order to obtain such consistent and efficient estimates. However, it may be difficult to specify an appropriate correlation structure for a real life data set. We propose a robust correlation structure that can be used irrespective of the true correlation structure. This structure is used in constructing an estimating equation for the hazard ratio parameter, under the assumption that the number of repeated failure times for an individual is random. The consistency and efficiency of the estimates is examined through a simulation study, where we consider failure times that marginally follow an exponential distribution and a Poisson distribution is assumed for the random number of repeated failure times. We conclude by using the proposed method to analyze a bladder cancer dataset.