Measures of lack of fit from tests of chi-squared type

If X² is the Pearson chi-squared statistic for testing fit, then $\text{X}{}^2\text{n}$ has long been considered an associated measure of the degree of lack of fit. Here we consider two classes of statistics of chi-squared type, each having X² as a member. The first is a class of directed divergence statistics discussed by Cressie and Read, the second consists of nonnegative definite quadratic forms in the standardized cell frequencies. We investigate the large sample behavior of $\text{T}\text{n}$, where T is any of these statistics. A number of auxiliary results on the Cressie-Read statistics are also obtained. The measures are illustrated by application to data from classical physics compiled by Stigler.     

TEST FOR TREATMENT EFFECT BASED ON BINARY DATA WITH RANDOM SAMPLE SIZES

The problem of testing for treatment effect based on binary response data is considered, assuming that the sample size for each experimental unit and treatment combination is random. It is assumed that the sample size follows a distribution that belongs to a parametric family. The uniformly most powerful unbiased tests, which are equivalent to the likelihood ratio tests, are obtained when the probability of the sample size being zero is positive. For the situation where the sample sizes are always positive, the likelihood ratio tests are derived. These test procedures, which are unconditional on the random sample sizes, are useful even when the random sample sizes are not observed. Some examples are presented as illustration.     

Designing historical control studies with survival endpoints using exact statistical inference

Historical control trials compare an experimental treatment with a previously conducted control treatment. By assigning all recruited samples to the experimental arm, historical control trials can better identify promising treatments in early phase trials compared with randomized control trials. Existing designs of historical control trials with survival endpoints are based on asymptotic normal distribution. However, it remains unclear whether the asymptotic distribution of the test statistic is close enough to the true distribution given relatively small sample sizes in early phase trials. In this article, we address this question by introducing an exact design approach for exponentially distributed survival endpoints, and compare it with an asymptotic design in both real examples and simulation examples. Simulation results show that the asymptotic test could lead to bias in the sample size estimation. We conclude the proposed exact design should be used in the design of historical control trials.     

A Note on the Estimation of Binomial Probabilities

I am concerned with the admissibility under quadratic loss of certain estimators of binomial probabilities. The minimum variance unbiased estimator is shown to be admissible for Pr(X = 0) and Pr(X = n), but it is inadmissible for Pr(X = k), where 0 < k < n. An example is given of an admissible maximum likelihood estimator (MLE). It is conjectured that the MLE is always admissible.     

The Gauss—Markov Theorem and Random Regressors

In the standard linear regression model with independent, homoscedastic errors, the Gauss—Markov theorem asserts that = (X'X)^-1(X'y) is the best linear unbiased estimator of β and, furthermore, that is the best linear unbiased estimator of c'β for all p × 1 vectors c. In the corresponding random regressor model, X is a random sample of size n from a p-variate distribution. If attention is restricted to linear estimators of c'β that are conditionally unbiased, given X, the Gauss—Markov theorem applies. If, however, the estimator is required only to be unconditionally unbiased, the Gauss—Markov theorem may or may not hold, depending on what is known about the distribution of X. The results generalize to the case in which X is a random sample without replacement from a finite population.     

Using generalized doubly robust estimator to estimate average treatment effects of multiple treatments in observational studies

The generalized doubly robust estimator is proposed for estimating the average treatment effect (ATE) of multiple treatments based on the generalized propensity score (GPS). In medical researches where observational studies are conducted, estimations of ATEs are usually biased since the covariate distributions could be unbalanced among treatments. To overcome this problem, Imbens [The role of the propensity score in estimating dose-response functions, Biometrika 87 (2000), pp. 706–710] and Feng et al. [Generalized propensity score for estimating the average treatment effect of multiple treatments, Stat. Med. (2011), in press. Available at: http://onlinelibrary.wiley.com/doi/10.1002/sim.4168/abstract] proposed weighted estimators that are extensions of a ratio estimator based on GPS to estimate ATEs with multiple treatments. However, the ratio estimator always produces a larger empirical sample variance than the doubly robust estimator, which estimates an ATE between two treatments based on the estimated propensity score (PS). We conduct a simulation study to compare the performance of our proposed estimator with Imbens’ and Feng et al.’s estimators, and simulation results show that our proposed estimator outperforms their estimators in terms of bias, empirical sample variance and mean-squared error of the estimated ATEs.     

On discrete-domain multidimensional sinusoidal models

We consider three-dimensional sinusoidal frequency model in a random field. Three-dimensional frequency model has wide applications in statistical signal processing. In this article, we mainly consider the usual least squares estimators and the estimators that can be obtained by maximizing the periodogram function. We obtain consistency and asymptotic normality property of both the estimators. It is observed that they are asymptotically equivalent. Finally we generalize the results to the multidimensional case.     

On robust Bayesian estimation under some asymmetric and bounded loss function

The problem of Bayesian and robust Bayesian estimation with some bounded and asymmetric loss function ABL is considered for various models. The prior distribution is not exactly specified and covers the conjugate family of prior distributions. The posterior regret, most robust and conditional Γ-minimax estimators are constructed and a preliminary comparison with square-error loss and LINEX loss is presented.     

Estimation of the location of a 0-type or ∞-type singularity by Poisson observations

We consider an inhomogeneous Poisson process X on [0, T]. The intensity function of X is supposed to be strictly positive and smooth on [0, T] except at the point θ, in which it has either a 0-type singularity (tends to 0 like |x| ^p , p∈(0, 1)), or an ∞-type singularity (tends to ∞ like |x| ^p , p∈(?1, 0)). We suppose that we know the shape of the intensity function, but not the location of the singularity. We consider the problem of estimation of this location (shift) parameter θ based on n observations of the process X. We study the Bayesian estimators and, in the case p>0, the maximum-likelihood estimator. We show that these estimators are consistent, their rate of convergence is n ^1/(p+1), they have different limit distributions, and the Bayesian estimators are asymptotically efficient.     

On a distributionfree method in discriminant analysis

Linear discriminant rules for two symmetrical distributions, which only need the first and second moments of these distributions, are presented. The rules are based on Zhezhel's idea using the most unfavourable probabilities of misclassification as an optimality criterion. Also a rule is considered which deals with distributions differing in a location and scale parameter.