A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

Progress and cumulation in the human sciences after the fall

What do we mean by progress and cumulation in the social and human sciences? Recent thinking in the philosophy and history of science has led to an abandonment of some versions of logical positivism and of verificationism that had a strong deductive and theory testing orientation. What is to replace them is less clear. This paper argues that progress and cumulation can be seen as a process of evaluation and retention within an epistemic community. Scholarly disciplines differ in their social structure and in their epistemic and normative commitments. Since sociology is a fragmented discipline, progress and cumulation differ within its multiple subdisciplines, which to varying extents represent epistemic communities. Brief sketches of progress (advance) and cumulation in several subdisciplines are offered.     

语言冗余现象在英语教学中的作用初探

冗余是人类语言的固有特征。冗余现象的研究在语言学中占据重要地位,它对语言教学的影响也日益受到重视。本文利用语言测试手段,通过实验验证了冗余理论在英语教学中的积极作用     

民族地区构建和谐社会应加强对传统多元生态文化的利用和改造

“人与自然和谐相处”是社会主义和谐社会的六个基本特征之一,民族地区构建社会主义和谐社会必须考虑到传统多元生态文化的功能。在开放的、以市场经济为主导的现代社会生态经济系统下,传统多元生态文化的约束力远不如在传统社会生态经济系统中那么有效、广泛。民族地区只有在维护自身生态经济系统可持续运作的基础上,进一步加强对传统多元生态文化的利用和改造,才能充分发挥生态文化的协调功能。因此,民族地区应当在继续维护传统生态文化的多元性、科学性和合理性的同时,根据现行社会生态经济系统的特征,把其改造成为“强生态文化”,构建以科学发展观为基础,具有较强约束力的、适应现行社会生态经济系统的、协调人与自然关系的,包括精神、物质、制度层面的整体文化体系。     

Joint impact of multiple observations on a subset of variables in multiple linear regression

In multiple linear regression analysis, each observation affects the fitted regression equation differently and has varying influences on the regression coefficients of the different variables. Chatterjee & Hadi (1988) have proposed some measures such as DSSE_ij (Impact on Residual Sum of Squares of simultaneously omitting the ith observation and the jth variable), F_j (Partial F-test for the jth variable) and F_j(i) (Partial F-test for the jth variable omitting the ith observation) to show the joint impact and the interrelationship that exists among a variable and an observation. In this paper we have proposed more extended form of those measures DSSE_IJ, F_J and F_J(I) to deal with the interrelationships that exist among the multiple observations and a subset of variables by monitoring the effects of the simultaneous omission of multiple variables and multiple observations.     

互联网信息服务业多元共治模式的作用机制研究——基于多参数影响的演化博弈视角

互联网信息服务业多元共治模式需要政府部门积极引导社会相关主体参与治理过程,若政府部门对协会与公众在治理过程中的作用条件认识不清,易导致片面追求二者的高参与度水平,难以实现多元共治模式的最大效用。本文考虑协会参与度、权力空间以及公众参与度、举报公正程度四个影响参数,运用博弈理论分析政府部门与互联网信息服务企业在治理过程中的行为策略演化过程,通过分析参数变动对系统稳定性的影响,探究有效发挥多元共治模式作用的条件。研究表明提高协会权利空间及公众举报公正程度有助于多元共治模式作用的发挥;公众举报存在失真情况时,政府自身监管能力的大小决定公众参与对治理效果的影响。     

“一核多元”型社区综合整治合作生产模式研究 ———以北京市 J 社区为例

老旧小区综合整治事关公众切身利益,体现国家服务效能与治理能力。 基于合作生产理论、公共价值和战略三角模 型间关系,从党建引领视角提出“一核多元”型综合整治合作生产模式。 以北京市 J 社区为例,采用张力分析工具,从使命管 理、政治管理与运营管理层面建构综合整治张力分析模型。 分析发现,党建引领的综合整治合作生产可促进社区合作生产网 络的形成与发展,这对社区治理模式创新与社区治理共同体建设具有重要意义。     

The design of organizations and the right to act

Recent innovations in the structure of formal organizations suggest possible directions for the design of schools to bring about high achievement. The structure of output-driven in contrast to administratively-driven schools is described, and designs are described which address both the goal of high achievement and the goal of reduced inequality.An earlier version of this paper was presented as the author's Sorokin Lecture at the annual meeting of the Eastern Sociological Society, Boston, March 1993.     

经济收敛理论与检验方法研究综述

在大量文献研究的基础上,对收敛问题的产生及收敛概念的发展作了全面概括,并对绝对收敛、条件收敛、俱乐部收敛和σ收敛作了深入辨析,对各种识别方法作了全面归纳。归纳了对世界大多数国家和地区数据所作识别的结果。还从收敛理论与传统理论的冲突与协调方面作了深入分析。最后对近年收敛研究的深化与扩展研究的趋势作了概括。