Testing for lack of fit in linear multiresponse models based on exact or near replicates

Three procedures for testing the adequacy of a proposed linear multiresponse regression model against unspecified general alternatives are considered. The model has an error structure with a matrix normal distribution which allows the vector of responses for a particular run to have an unknown covariance matrix while the responses for different runs are uncorrelated. Furthermore, each response variable may be modeled by a separate design matrix. Multivariate statistics corresponding to the classical univariate lack of fit and pure error sums of squares are defined and used to determine the multivariate lack of fit tests. A simulation study was performed to compare the power functions of the test procedures in the case of replication. Generalizations of the tests for the case in which there are no independent replicates on all responses are also presented.     

On detection of outliers in symmetric normal models

Extensions of recent results for detection of mean slippage type outliers from i.i.d. multivariate normal and elliptically symmetric distributions are made to symmetric case, that is, when the observations are equicorrelated. The main tool used is Wijsman's (1967) representation theorem. The results obtained can be viewed as a robustness property of the use of Mardia's multivariate kurtosis as a locally optimal test statistic to detect outliers against equicorrelated distributions.     

The exact noncentral distribution of the generalized multiple correlation matrix

Given p×n X N(βY, ∑?I), β, ∑ unknown, the noncentral multivariate beta density of the matrix L = [(YY′)^-1/2Y X′ (XX′)^-1XY′ (YY′)^-1/2] is desired. Khatri (1964) finds this density when β is of rank unity. The present paper derives the noncentral density of L and the density of the roots matrix of L for full rank β. The dual case density of L is also obtained. The derivations are based on generalized Sverdrup's lemma, Kabe (1965), and the relationship between primal and dual density of L is explicitly established.     

On estimating the dimensionality in discriminant analysis

In discriminant analysis, the dimension of the hyperplane which population mean vectors span is called the dimensionality. The procedures commonly used to estimate this dimension involve testing a sequence of dimensionality hypotheses as well as model fitting approaches based on (consistent) Akaike's method, (modified) Mallows' method and Schwarz's method. The marginal log-likelihood (MLL) method is developed and the asymptotic distribution of the dimensionality estimated by this method for normal populations is derived. Furthermore a modified marginal log-likelihood (MMLL) method is also considered. The MLL method is not consistent for large samples and two modified criteria are proposed which attain asymptotic consistency. Some comments are made with regard to the robustness of this method to departures from normality. The operating characteristics of the various methods proposed are examined and compared.     

Predictive inference for linear and multivariate linear models with ma(1) error processes

The prediction distributions of future responses from the linear and multivariate linear models with errors having a first order moving average (MA(1)) process have been derived. First, we obtained the marginal likelihood function for the moving average parameter 6 and from this likelihood function we estimate the maximum likelihood estimates (MLE) of θ. Using the estimated value θ, we have derived the prediction distributions as well as prediction regions for the future responses. An example has been included.     

Group sequential x2 statistic for testing the difference of two mean vectors in clinical trials

In this study we discuss the group sequential procedures for comparing two treatments based on multivariate observations in clinical trials. Also we suppose that a response vector on each of two treatments has a multivariate normal distribution with unknown covariance matrix. Then we propose a group sequential x² statistic in order to carry out repeated significance test for hypothesis of no difference between two population mean vectors. In order to realize the group sequential test where average sample number is reduced, we propose another modified group sequential x² statistic by extension of Jennison and Turnbull ( 1991 ). After construction of repeated confidence boundaries for making the repeated significance test, we compare two group sequential procedures based on two statistics regarding the average sample number and the power of the test in the simulations.     

P-value adjustment for multiple binary endpoints

The p-value-based adjustment of individual endpoints and the global test for an overall inference are the two general approaches for the analysis of multiple endpoints. Statistical procedures developed for testing multivariate outcomes often assume that the multivariate endpoints are either independent or normally distributed. This paper presents a general approach for the analysis of multivariate binary data under the framework of generalized linear models. The generalized estimating equations (GEE) approach is applied to estimate the correlation matrix of the test statistics using the identity and exchangeable working correlation matrices with the model-based as well as robust estimators. The objectives of the approaches are the adjustment of p-values of individual endpoints to identify the affected endpoints as well as the global test of an overall effect. A Monte Carlo simulation was conducted to evaluate the overall family wise error (FWE) rates of the single-step down p-value adjustment approach from two adjustment methods to three global test statistics. The p-value adjustment approach seems to control the FWE better than the global approach Applications of the proposed methods are illustrated by analyzing a carcinogenicity experiment designed to study the dose response trend for 10 tumor sites, and a developmental toxicity experiment with three malformation types: external, visceral, and skeletal.     

A network algorithm for the exact treatment of the 2×k contingency table

A common statistical problem encountered in biomedical research is to test the hypothesis that the parameters of k binomial populations are all equal. An exact test of significance of this hypothesis is possible in principle, the appropriate null distribution being a normalized product of k binomial coefficients. However, the problem of computing the tail area of this distribution can be formidable since it requires the enumeration of all sets of k binomial coefficients whose product is less than a given constant. Existing algorithms, all of which rely on explicit enumeration to generate feasible binomial coefficients