ROBUST METHODS FOR DEPENDENT CELL PEDIGREE DATA

This paper studies a robust approach to the analysis of cell pedigree data, building on the work of Huggins & Marschner (1991) which discussed M-estimation for the so-called bifurcating autoregressive process. The study allows for incomplete observation of the pedigree, and incorporates the possibility of additive effects outliers, as discussed in the time series literature. Some properties of the proposed estimation procedure are studied, including a Monte Carlo investigation of robustness in the presence of contamination.     

TESTING SPHERICITY UNDER A MIXTURE MODEL

The robustness of Mauchly's sphericity test criterion when sampling from a mixture of two multivariate normal distributions is studied. The distribution of the sphericity test criterion when the sample covariance matrix has a non-central Wishart density of rank one is derived in terms of Meijer's G-functions; its distribution under the mixture model is then deduced. The robustness is studied by computing actual significance levels of the test under the mixture model using the critical values under the usual normal model.     

现象学的问题如何发生--德里达对胡塞尔发生现象学的解读

德里达对胡塞尔的发生现象学有他自己的特殊理解,他研究了观念的历史,以及根据所形成的心理习惯构成的观念,当然,这也是观念对象构成的历史过程。发生是一个陌生的过程:在即将来临的历史中包含着一种中断。德里达描述了从某种确定的目的论返回到胡塞尔所新近确立的起源问题的运动结构。德里达研究稳定的结构与发生现象学之间的关系,在这个过程中,德里达提出了关于解构的基本问题。     

数控机床功能的扩展

本文主要分析了HEIDENHAIN TNC 310数控铣床系统中圆弧铣削指令及螺纹铣削指令,对螺纹铣削功能进行延伸,扩展到圆弧三轴联动,并对螺纹铣削指令格式进行了修改,从而具有圆弧三轴联动铣削功能。     

贾岛为僧及还俗时间地点考

贾岛出家及还俗的时间地点问题是贾岛生平仕历研究的一个重要问题。通过对现有史料记载以及贾岛等人诗文的考证分析,可知贾岛贞元九年(793)在北岳恒山出家为僧,时年15岁。后曾住洛阳石楼及嵩山一带。贞元十七年(801)在石楼与韩愈初次相识。元和六年(811)春在洛阳又遇到时任河南县令的韩愈,同年秋跟随韩愈赴长安准备应进士举,但并未马上还俗。冬十一月返回家乡范阳,处理僧俗事务。至迟于次年即元和七年(812)春还俗并参加进士考试,时年34岁。     

Marginal and association regression models for longitudinal binary data with drop‐outs: A likelihood‐based approach

Longitudinal data often contain missing observations, and it is in general difficult to justify particular missing data mechanisms, whether random or not, that may be hard to distinguish. The authors describe a likelihood‐based approach to estimating both the mean response and association parameters for longitudinal binary data with drop‐outs. They specify marginal and dependence structures as regression models which link the responses to the covariates. They illustrate their approach using a data set from the Waterloo Smoking Prevention Project They also report the results of simulation studies carried out to assess the performance of their technique under various circumstances.     

A note on interval‐censored lifetime data and the constant‐sum condition of oiler,gómez & calle (2004)

Oiler, Gomez & Calle (2004) give a constant sum condition for processes that generate interval‐censored lifetime data. They show that in models satisfying this condition, it is possible to estimate non‐parametrically the lifetime distribution based on a well‐known simplified likelihood. The author shows that this constant‐sum condition is equivalent to the existence of an observation process that is independent of lifetimes and which gives the same probability distribution for the observed data as the underlying true process.     

A theoretical basis for perturbation methods

In this paper we discuss a new theoretical basis for perturbation methods. In developing this new theoretical basis, we define the ideal measures of data utility and disclosure risk. Maximum data utility is achieved when the statistical characteristics of the perturbed data are the same as that of the original data. Disclosure risk is minimized if providing users with microdata access does not result in any additional information. We show that when the perturbed values of the confidential variables are generated as independent realizations from the distribution of the confidential variables conditioned on the non-confidential variables, they satisfy the data utility and disclosure risk requirements. We also discuss the relationship between the theoretical basis and some commonly used methods for generating perturbed values of confidential numerical variables.     

The analysis of incomplete data using stochastic covariates

In the development of many diseases there are often associated random variables which continuously reflect the progress of a subject towards the final expression of the disease (failure). At any given time these processes, which we call stochastic covariates, may provide information about the current hazard and the remaining time to failure. Likewise, in situations when the specific times of key prior events are not known, such as the time of onset of an occult tumour or the time of infection with HIV-1, it may be possible to identify a stochastic covariate which reveals, indirectly, when the event of interest occurred. The analysis of carcinogenicity trials which involve occult tumours is usually based on the time of death or sacrifice and an indicator of tumour presence for each animal in the experiment. However, the size of an occult tumour observed at the endpoint represents data concerning tumour development which may convey additional information concerning both the tumour incidence rate and the rate of death to which tumour-bearing animals are subject. We develop a stochastic model for tumour growth and suggest different ways in which the effect of this growth on the hazard of failure might be modelled. Using a combined model for tumour growth and additive competing risks of death, we show that if this tumour size information is used, assumptions concerning tumour lethality, the context of observation or multiple sacrifice times are no longer necessary in order to estimate the tumour incidence rate. Parametric estimation based on the method of maximum likelihood is outlined and is applied to simulated data from the combined model. The results of this limited study confirm that use of the stochastic covariate tumour size results in more precise estimation of the incidence rate for occult tumours.     

Local spatial data infrastructure, Trujillo-Peru

The development of a Municipal Information System, or currently better known as a local spatial data infrastructure, is considered complex due to the required inter-institutional relationships. In many developing countries Geographical Information Systems (GISs) are introduced but the benefits are modest as no changes take place in technical and organisational structure of organisations. Digital databases and computer-aided design (CAD) maps are mushrooming in great variety within different private and public institutions, municipal organisations and even within single departments and with structures similar to the paper period and thus operating on a stand-alone basis.Many national mapping agencies are not able to provide large-scale digital urban base maps, while the absence or low quality of cadastres makes those basic core data sets unavailable or inaccessible. The result is that duplication and incompatible data are frequently observed and also donor-driven stand-alone projects have a limited impact through the lack of institutional embedding and are not able to mature from the project to the institutional level. However, a positive sign is that there is an increasing awareness among data producers and consumers that investments in the development of digital data sets should be combined to reduce costs and increase benefits from especially GIS, and information and communication technology (ICT) in general.Within Trujillo a long-term vision was developed to make full use of ICT and GIS to modernise all operations of the Municipality to increase the efficiency and effectiveness of its tasks. However, large investments are not feasible due to the very limited municipal budgets. To guarantee the support of the municipal council, short-term results are required. This paper describes three ‘products’ as part of the vision to develop through a step-by-step approach a local spatial data infrastructure for Trujillo.The three, rather different, products are:

1. fiscal cadastre, to increase municipal revenues through property taxation;

2. an ‘environmental atlas’ based on a compatible spatial and attribute data sets from a variety of organisations; and

3. a municipal website with interactive GIS and meta data information.

The paper concludes with some comments on the institutional and political requirements for the successful development of a local spatial data infrastructure and stresses that such an infrastructure is not a product but an incremental development process that will progress only in case such a process is simple, cost effective, user-friendly, and flexible with clear products.Political interest and institutional stability and genuine interest for inter-institutional cooperation will add much to the success of this process.