A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

公民权与美国工业化时期缩短工时运动研究

在工业化时期,美国人们形成了"私人时间"的观念。他们普遍相信,过长的工时侵犯了自己的私人时间,而拥有私人时间是共和国公民的天然权利。这种思想成为缩短工时运动的重要思想基础,促进运动的蓬勃发展。然而,受契约自由传统的影响,运动仅取得了有限的成就,工人获得合理工作时间和私人时间的路途仍很艰辛漫长。     

Book Reviews

Books reviewed:
R.J. Adler, R.E. Feldman & M.S. Taqqu, A Practical Guide to Heavy Tails: Statistical Techniques and Applications.
J.J. Foste, A Beginner's Guide to Data Analysis Using SPSS for Windows.
N. Limnios and G. Oprisan, Semi–Markov Processes and Reliability.     

Confidence Intervals for Current Status Data

Abstract.  The likelihood ratio statistic for testing pointwise hypotheses about the survival time distribution in the current status model can be inverted to yield confidence intervals (CIs). One advantage of this procedure is that CIs can be formed without estimating the unknown parameters that figure in the asymptotic distribution of the maximum likelihood estimator (MLE) of the distribution function. We discuss the likelihood ratio-based CIs for the distribution function and the quantile function and compare these intervals to several different intervals based on the MLE. The quantiles of the limiting distribution of the MLE are estimated using various methods including parametric fitting, kernel smoothing and subsampling techniques. Comparisons are carried out both for simulated data and on a data set involving time to immunization against rubella. The comparisons indicate that the likelihood ratio-based intervals are preferable from several perspectives.     

Making the Best of a Bad Job? Female Part‐Timers’ Orientations and Attitudes to Work

This article uses data from 50 qualitative interviews with female part‐time workers in low‐level jobs in Britain to illustrate their attitudes, orientations and aspirations towards paid work. The research reports two main findings. Firstly, even female part‐time workers at the bottom end of the occupational structure are not a homogeneous group of workers. Secondly, they are not all highly satisfied with their jobs. The article argues that many women (especially those in working‐class households) still do not have a genuine choice between ‘family work’ and ‘market work’. It concludes by presenting a theoretical model of orientations to work.     

一个数据流查询系统的设计与实现

就目前大多数数据流查询处理过程中可能出现的一些问题，根据数据流处理的特点和要求，提出了新的查询处理结构，实现了数据共享及多流多查询环境下查询的处理．     

CCI与中国证券市场走势的实证分析

美英等国的消费者信心指数(CCI)对股市指数收益有很重要的影响力。为探讨CCI与中国证券市场走势的相关关系,通过两类模型对1999年10月~2004年8月间我国股市收益与CCI之间的关系进行了实证分析。结果表明:CCI对深沪五个指数的走势有显著的解释与预测效果,但对我国的B股市场似乎没有显著性。     

An evaluation of the childhood family structure measures from the sixth wave of the British Household Panel Survey

Summary.  The paper performs an evaluation of the data that were collected in the sixth wave of the British Household Panel Survey (BHPS) on childhood family structure. After comparing such data with a large number of studies by using external sources, we find that the BHPS data overestimate the proportion of people who report an experience of life in a non-intact family during childhood by about 10%. Although an explanation based on recall error that deteriorates with the age of the BHPS respondents is possible, the overestimation is likely to be accounted for by non-ignorable attrition that may affect most of the comparison studies based on longitudinal data. Conversely, comparisons with other independent measurements from the BHPS itself reveal that the wave 6 data underestimate the proportion of young people who have lived at least part of their childhood in a non-intact family by about 8%. The probability of disagreement between these two sets of measures is strongly associated with poor interview characteristics, which may affect the comparison measure more than the wave 6 measure. Despite such differences, there is therefore a substantial degree of similarity between the family structure information that was collected in the sixth wave of the BHPS and the host of highly diverse records against which it has been compared.     

基于拥挤收费的动态出发时间选择

针对动态交通分配领域中往往假定所有车辆的出发时间是固定的不正确假设，探讨基于拥挤收费的出发时间选择问题的负效用函数，建立动态出发时间选择问题的变分不等式模型．结果表明，建立的变分不等式模型等价于动态用户最优出发时间选择问题.     

Semiparametric linear transformation models for current status data

Current status data arise when the death of every subject in a study cannot be determined precisely, but is known only to have occurred before or after a random monitoring time. The authors discuss the analysis of such data under semiparametric linear transformation models for which they propose a general inference procedure based on estimating functions. They determine the properties of the estimates they propose for the regression parameters of the model and illustrate their technique using tumorigenicity data.