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61.
62.
Clinical trials are often designed to compare continuous non‐normal outcomes. The conventional statistical method for such a comparison is a non‐parametric Mann–Whitney test, which provides a P‐value for testing the hypothesis that the distributions of both treatment groups are identical, but does not provide a simple and straightforward estimate of treatment effect. For that, Hodges and Lehmann proposed estimating the shift parameter between two populations and its confidence interval (CI). However, such a shift parameter does not have a straightforward interpretation, and its CI contains zero in some cases when Mann–Whitney test produces a significant result. To overcome the aforementioned problems, we introduce the use of the win ratio for analysing such data. Patients in the new and control treatment are formed into all possible pairs. For each pair, the new treatment patient is labelled a ‘winner’ or a ‘loser’ if it is known who had the more favourable outcome. The win ratio is the total number of winners divided by the total numbers of losers. A 95% CI for the win ratio can be obtained using the bootstrap method. Statistical properties of the win ratio statistic are investigated using two real trial data sets and six simulation studies. Results show that the win ratio method has about the same power as the Mann–Whitney method. We recommend the use of the win ratio method for estimating the treatment effect (and CI) and the Mann–Whitney method for calculating the P‐value for comparing continuous non‐Normal outcomes when the amount of tied pairs is small. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
63.
在新常态的话语背景下,传统高校形势与政策课程模式越来越不适应现代需求,与教学对象的新特点存在若干不协调、不衔接、不到位之处。为适应新常态,改进高校形势与政策课程模式,提升实效性,文章从宏观层面分析新常态下高校形势与政策课程目标及现实困境,认为需要从优化教学力量构成、改进理论教学体系、拓展实践教学平台及构建管理保障机制等方面做出改进。 相似文献
64.
Shaun R. Seaman Daniel Farewell Ian R. White 《Scandinavian Journal of Statistics》2016,43(4):996-1018
Linear increments (LI) are used to analyse repeated outcome data with missing values. Previously, two LI methods have been proposed, one allowing non‐monotone missingness but not independent measurement error and one allowing independent measurement error but only monotone missingness. In both, it was suggested that the expected increment could depend on current outcome. We show that LI can allow non‐monotone missingness and either independent measurement error of unknown variance or dependence of expected increment on current outcome but not both. A popular alternative to LI is a multivariate normal model ignoring the missingness pattern. This gives consistent estimation when data are normally distributed and missing at random (MAR). We clarify the relation between MAR and the assumptions of LI and show that for continuous outcomes multivariate normal estimators are also consistent under (non‐MAR and non‐normal) assumptions not much stronger than those of LI. Moreover, when missingness is non‐monotone, they are typically more efficient. 相似文献
65.
This article proposes a linearly weighted unit root test with a new weighting scheme which reflects the trade-off in power between the ADF and LM tests regarding the initial value of a time series. Simulation results indicate that the proposed test has better power performance and works better than other available tests in the literature for a range of initial conditions. 相似文献
66.
Most existing reduced-form macroeconomic multivariate time series models employ elliptical disturbances, so that the forecast densities produced are symmetric. In this article, we use a copula model with asymmetric margins to produce forecast densities with the scope for severe departures from symmetry. Empirical and skew t distributions are employed for the margins, and a high-dimensional Gaussian copula is used to jointly capture cross-sectional and (multivariate) serial dependence. The copula parameter matrix is given by the correlation matrix of a latent stationary and Markov vector autoregression (VAR). We show that the likelihood can be evaluated efficiently using the unique partial correlations, and estimate the copula using Bayesian methods. We examine the forecasting performance of the model for four U.S. macroeconomic variables between 1975:Q1 and 2011:Q2 using quarterly real-time data. We find that the point and density forecasts from the copula model are competitive with those from a Bayesian VAR. During the recent recession the forecast densities exhibit substantial asymmetry, avoiding some of the pitfalls of the symmetric forecast densities from the Bayesian VAR. We show that the asymmetries in the predictive distributions of GDP growth and inflation are similar to those found in the probabilistic forecasts from the Survey of Professional Forecasters. Last, we find that unlike the linear VAR model, our fitted Gaussian copula models exhibit nonlinear dependencies between some macroeconomic variables. This article has online supplementary material. 相似文献
67.
In this paper we propose a new lifetime model for multivariate survival data in presence of surviving fractions and examine some of its properties. Its genesis is based on situations in which there are m types of unobservable competing causes, where each cause is related to a time of occurrence of an event of interest. Our model is a multivariate extension of the univariate survival cure rate model proposed by Rodrigues et al. [37]. The inferential approach exploits the maximum likelihood tools. We perform a simulation study in order to verify the asymptotic properties of the maximum likelihood estimators. The simulation study also focus on size and power of the likelihood ratio test. The methodology is illustrated on a real data set on customer churn data. 相似文献
68.
This paper provides a Bayesian estimation procedure for monotone regression models incorporating the monotone trend constraint subject to uncertainty. For monotone regression modeling with stochastic restrictions, we propose a Bayesian Bernstein polynomial regression model using two-stage hierarchical prior distributions based on a family of rectangle-screened multivariate Gaussian distributions extended from the work of Gurtis and Ghosh [7]. This approach reflects the uncertainty about the prior constraint, and thus proposes a regression model subject to monotone restriction with uncertainty. Based on the proposed model, we derive the posterior distributions for unknown parameters and present numerical schemes to generate posterior samples. We show the empirical performance of the proposed model based on synthetic data and real data applications and compare the performance to the Bernstein polynomial regression model of Curtis and Ghosh [7] for the shape restriction with certainty. We illustrate the effectiveness of our proposed method that incorporates the uncertainty of the monotone trend and automatically adapts the regression function to the monotonicity, through empirical analysis with synthetic data and real data applications. 相似文献
69.
胡鸣焕 《宝鸡文理学院学报(社会科学版)》2007,27(1):122-125
基础教育与高等师范教育是人才成长的摇篮,而且是教育的两个不同等级的环节.基础教育对中小学生基本素质的形成与知识能力的培养起着不可替代的作用,基础教育质量的提高取决于中小学教师质量的提高;高等师范教育及高等师范院校是学生素质提升与能力提高的关键时期,高等师范教育的目标是为基础教育服务,双方的合作与交流是成功培养人才的需求和必由之路. 相似文献
70.
蒋清华 《北京化工大学学报(社会科学版)》2007,(3):17-20
以义务性规范的形式对宪法权利作出的限制规定,就是宪法中的权界式公民义务规范,它有概括限制型和具体限制型两种类型。宪法权利的法律保留限制式规定,不应视为公民义务规范。权界式义务规范在创设目的、出现位置、表述转换等方面与明示式义务规范有着重大区别。权界式义务规范附属于公民宪法权利规范本身,它可以转换成非义务性的表述,其实质是表示权利应当有所约束。关于宪法权利之限制规定能否被视为公民义务规范的争议,可通过形式与实质的双重视角予以化解。 相似文献