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61.
62.
Joel Schwartz 《Revue canadienne de statistique》1994,22(4):471-487
While most of epidemiology is observational, rather than experimental, the culture of epidemiology is still derived from agricultural experiments, rather than other observational fields, such as astronomy or economics. The mismatch is made greater as focus has turned to continue risk factors, multifactorial outcomes, and outcomes with large variation unexplainable by available risk factors. The analysis of such data is often viewed as hypothesis testing with statistical control replacing randomization. However, such approaches often test restricted forms of the hypothesis being investigated, such as the hypothesis of a linear association, when there is no prior empirical or theoretical reason to believe that if an association exists, it is linear. In combination with the large nonstochastic sources of error in such observational studies, this suggests the more flexible alternative of exploring the association. Conclusions on the possible causal nature of any discovered association will rest on the coherence and consistency of multiple studies. Nonparametric smoothing in general, and generalized additive models in particular, represent an attractive approach to such problems. This is illustrated using data examining the relationship between particulate air pollution and daily mortality in Birmingham, Alabama; between particulate air pollution, ozone, and SO2 and daily hospital admissions for respiratory illness in Philadelphia; and between ozone and particulate air pollution and coughing episodes in children in six eastern U.S. cities. The results indicate that airborne particles and ozone are associated with adverse health outcomes at very low concentrations, and that there are likely no thresholds for these relationships. 相似文献
63.
本文通过建立博弈矩阵模型,并利用线性规划理论进行分析,指出房地产企业在提高工资待遇吸引人才的同时,建立有效的动态激励机制才是留住人才的关键. 相似文献
64.
Peter J. Robinson 《Risk analysis》1992,12(1):139-148
Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments. 相似文献
65.
66.
乐茂华 《湛江师范学院学报》2002,23(6):4-6
设p是奇素数,D是适合p D是正奇数,证明了,当D≠Ap^r-1,其中r是正整数时,方程x^2 D=4p^n至多有1组正整数解(x,n)。 相似文献
67.
对偶线性规划问题性质探析 总被引:1,自引:0,他引:1
探讨对偶线性规划的原始问题与对偶问题的属性,阐述两者的区别和内在联系,用较简便的方法论证其重要性质,揭示可行解与目标函数、可行解与最优解的关系,指出线性规划问题最优解从约束条件较少的对偶问题寻求为另一较简便之方法。 相似文献
68.
从篇章语言学的角度看 ,英文段落依层级的概括性推展 ,并呈典型的直线性发展模式。英文作者主要利用词汇相等链、链式结构和编列结构衔接段中各语句来推展段落 ,从而使段落具有交际功能。英文语篇结构模式对英文习得者来说具有实际指导意义 相似文献
69.
Grard Letac 《Revue canadienne de statistique》1991,19(2):229-232
This note exhibits two independent random variables on integers, X1 and X2, such that neither X1 nor X2 has a generalized Poisson distribution, but X1 + X2 has. This contradicts statements made by Professor Consul in his recent book. 相似文献
70.
Paramjit S. Gill Tim B. Swartz 《Journal of the Royal Statistical Society. Series C, Applied statistics》2004,53(2):249-260
Summary. A fully Bayesian analysis of directed graphs, with particular emphasis on applica- tions in social networks, is explored. The model is capable of incorporating the effects of covariates, within and between block ties and multiple responses. Inference is straightforward by using software that is based on Markov chain Monte Carlo methods. Examples are provided which highlight the variety of data sets that can be entertained and the ease with which they can be analysed. 相似文献