Offspring of Parents with Gambling Problems: Adjustment Problems and Explanatory Mechanisms

We compared offspring of problem gamblers (n = 42) to offspring of parents without gambling problems (n = 100) to see (1) whether the two groups differed with respect to depressive feelings and conduct/antisociality problems and (2) whether ineffective parenting or the offspring’s own gambling problems played a mediating role in this context. Participants were drawn from a relatively large community-based study (N = 1,872). Parents rated their own gambling and other mental health problems when their children were in mid-adolescence. The children’s self-reports on depressive feelings and conduct/antisociality problems were assessed at two points in time: by mid-adolescence and again by early adulthood. Results showed that children of parents with gambling problems reported more depressive feelings and more conduct problems by mid-adolescence than children of parents without gambling problems. Children of problem gamblers also experienced an increase in their depressive symptoms from mid-adolescence to early adulthood. Importantly, ineffective parenting, but not children’s gambling problems, mediated almost all the links between parental problem gambling and children’s adjustment problems. These results add to a very small data base showing that children of problem gamblers are at risk for a variety of adjustment problems.

超越对数生产函数的半参数变系数估计模型

提出超越对数生产函数的半参数变系数模型,利用Profile方法给出产出弹性函数系数的局部加权最小二乘估计,并利用非参数条件自助法对有限样本的近似分布进行模拟,给出相对精确的广义似然比检验。规模报酬约束下中国1953--2008年的实证结果拒绝超越对数生产函数模型假设,产出弹性不可简单线性化而是对数劳均资本的非线性函数,时变资本弹性表现为倒U型变化趋势,时变劳动力弹性表现为U型变化趋势。     

Graphical displays for clarifying how allocation ratio affects total sample size for the two sample logrank test

For time‐to‐event data, the power of the two sample logrank test for the comparison of two treatment groups can be greatly influenced by the ratio of the number of patients in each of the treatment groups. Despite the possible loss of power, unequal allocations may be of interest due to a need to collect more data on one of the groups or to considerations related to the acceptability of the treatments to patients. Investigators pursuing such designs may be interested in the cost of the unbalanced design relative to a balanced design with respect to the total number of patients required for the study. We present graphical displays to illustrate the sample size adjustment factor, or ratio of the sample size required by an unequal allocation compared to the sample size required by a balanced allocation, for various survival rates, treatment hazards ratios, and sample size allocation ratios. These graphical displays conveniently summarize information in the literature and provide a useful tool for planning sample sizes for the two sample logrank test. Copyright © 2010 John Wiley & Sons, Ltd.     

An alternative phase II/III design for continuous endpoints

The success rate of drug development has been declined dramatically in recent years and the current paradigm of drug development is no longer functioning. It requires a major undertaking on breakthrough strategies and methodology for designs to minimize sample sizes and to shorten duration of the development. We propose an alternative phase II/III design based on continuous efficacy endpoints, which consists of two stages: a selection stage and a confirmation stage. For the selection stage, a randomized parallel design with several doses with a placebo group is employed for selection of doses. After the best dose is chosen, the patients of the selected dose group and placebo group continue to enter the confirmation stage. New patients will also be recruited and randomized to receive the selected dose or placebo group. The final analysis is performed with the cumulative data of patients from both stages. With the pre‐specified probabilities of rejecting the drug at each stage, sample sizes and critical values for both stages can be determined. As it is a single trial with controlling overall type I and II error rates, the proposed phase II/III adaptive design may not only reduce the sample size but also improve the success rate. An example illustrates the applications of the proposed phase II/III adaptive design. Copyright © 2010 John Wiley & Sons, Ltd.     

On a class of m out of n bootstrap confidence intervals

It is widely known that bootstrap failure can often be remedied by using a technique known as the ' m out of n ' bootstrap, by which a smaller number, m say, of observations are resampled from the original sample of size n . In successful cases of the bootstrap, the m out of n bootstrap is often deemed unnecessary. We show that the problem of constructing nonparametric confidence intervals is an exceptional case. By considering a new class of m out of n bootstrap confidence limits, we develop a computationally efficient approach based on the double bootstrap to construct the optimal m out of n bootstrap intervals. We show that the optimal intervals have a coverage accuracy which is comparable with that of the classical double-bootstrap intervals, and we conduct a simulation study to examine their performance. The results are in general very encouraging. Alternative approaches which yield even higher order accuracy are also discussed.     

《汉语大词典》误释词目研究报告

《汉语大词典》是目前国内最大的一部历史性、民族性的大型汉语词典。它在释义方面存在着大量的"硬伤"和一般性释义失误。通过资料积累调查和抽样调查两种方法,对它的失误词目进行初步测估,发现它失误的词目当在1万条以上。这些失误严重影响了它的总体质量,并在一定程度上对读者产生一些误导作用。因此,发现并纠正这些释义错误,将是以后《汉语大词典》修订的一个核心任务。     

Outlier identification and robust parameter estimation in a zero-inflated Poisson model

The Zero-inflated Poisson distribution has been used in the modeling of count data in different contexts. This model tends to be influenced by outliers because of the excessive occurrence of zeroes, thus outlier identification and robust parameter estimation are important for such distribution. Some outlier identification methods are studied in this paper, and their applications and results are also presented with an example. To eliminate the effect of outliers, two robust parameter estimates are proposed based on the trimmed mean and the Winsorized mean. Simulation results show the robustness of our proposed parameter estimates.     

District-level poverty estimation: a proposed method

This paper develops a method of estimating micro-level poverty in cases where data are scarce. The method is applied to estimate district-level poverty using the household level Indian national sample survey data for two states, viz., West Bengal and Madhya Pradesh. The method involves estimation of state-level poverty indices from the data formed by pooling data of all the districts (each time excluding one district) and multiplying this poverty vector with a known weight matrix to obtain the unknown district-level poverty vector. The proposed method is expected to yield reliable estimates at the district level, because the district-level estimate is now based on a much larger sample size obtained by pooling data of several districts. This method can be an alternative to the “small area estimation technique” for estimating poverty at sub-state levels in developing countries.     

Relative risk regression for current status data in case‐cohort studies

We propose using the weighted likelihood method to fit a general relative risk regression model for the current status data with missing data as arise, for example, in case‐cohort studies. The missingness probability is either known or can be reasonably estimated. Asymptotic properties of the weighted likelihood estimators are established. For the case of using estimated weights, we construct a general theorem that guarantees the asymptotic normality of the M‐estimator of a finite dimensional parameter in a class of semiparametric models, where the infinite dimensional parameter is allowed to converge at a slower than parametric rate, and some other parameters in the objective function are estimated a priori. The weighted bootstrap method is employed to estimate the variances. Simulations show that the proposed method works well for finite sample sizes. A motivating example of the case‐cohort study from an HIV vaccine trial is used to demonstrate the proposed method. The Canadian Journal of Statistics 39: 557–577; 2011. © 2011 Statistical Society of Canada     

A domain outlier robust design and smooth estimation approach

Outliers that commonly occur in business sample surveys can have large impacts on domain estimates. The authors consider an outlier‐robust design and smooth estimation approach, which can be related to the so‐called “Surprise stratum” technique [Kish, “Survey Sampling,” Wiley, New York (1965)]. The sampling design utilizes a threshold sample consisting of previously observed outliers that are selected with probability one, together with stratified simple random sampling from the rest of the population. The domain predictor is an extension of the Winsorization‐based estimator proposed by Rivest and Hidiroglou [Rivest and Hidiroglou, “Outlier Treatment for Disaggregated Estimates,” in “Proceedings of the Section on Survey Research Methods,” American Statistical Association (2004), pp. 4248–4256], and is similar to the estimator for skewed populations suggested by Fuller [Fuller, Statistica Sinica 1991;1:137–158]. It makes use of a domain Winsorized sample mean plus a domain‐specific adjustment of the estimated overall mean of the excess values on top of that. The methods are studied in theory from a design‐based perspective and by simulations based on the Norwegian Research and Development Survey data. Guidelines for choosing the threshold values are provided. The Canadian Journal of Statistics 39: 147–164; 2011 © 2010 Statistical Society of Canada