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11.
Xing-De Duan 《Statistics》2016,50(3):525-539
This paper develops a Bayesian approach to obtain the joint estimates of unknown parameters, nonparametric functions and random effects in generalized partially linear mixed models (GPLMMs), and presents three case deletion influence measures to identify influential observations based on the φ-divergence, Cook's posterior mean distance and Cook's posterior mode distance of parameters. Fisher's iterative scoring algorithm is developed to evaluate the posterior modes of parameters in GPLMMs. The first-order approximation to Cook's posterior mode distance is presented. The computationally feasible formulae for the φ-divergence diagnostic and Cook's posterior mean distance are given. Several simulation studies and an example are presented to illustrate our proposed methodologies. 相似文献
12.
This paper discusses regression analysis of clustered current status data under semiparametric additive hazards models. In particular, we consider the situation when cluster sizes can be informative about correlated failure times from the same cluster. To address the problem, we present estimating equation-based estimation procedures and establish asymptotic properties of the resulting estimates. Finite sample performance of the proposed method is assessed through an extensive simulation study, which indicates the procedure works well. The method is applied to a motivating data set from a lung tumorigenicity study. 相似文献
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Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation
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Margaret Gamalo‐Siebers Jasmina Savic Cynthia Basu Xin Zhao Mathangi Gopalakrishnan Aijun Gao Guochen Song Simin Baygani Laura Thompson H. Amy Xia Karen Price Ram Tiwari Bradley P. Carlin 《Pharmaceutical statistics》2017,16(4):232-249
Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics. 相似文献
15.
In this paper, we propose a new partial correlation, the so-called composite quantile partial correlation, to measure the relationship of two variables given other variables. We further use this correlation to screen variables in ultrahigh-dimensional varying coefficient models. Our proposed method is fast and robust against outliers and can be efficiently employed in both single index variable and multiple index variable varying coefficient models. Numerical results indicate the preference of our proposed method. 相似文献
16.
This paper addresses the collinearity problems in semi-parametric linear models. Under the difference-based settings, we introduce a new diagnostic, the difference-based variance inflation factor (DVIF), for detecting the presence of multicollinearity in semi-parametric models. The DVIF is then used to device a difference-based matrix perturbation method for solving the problem. The electricities distribution data set is analyzed, and numerical evidences validate the effectiveness of the proposed method. 相似文献
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This paper discusses the regression analysis of current status failure time data arising from the additive hazards model with auxiliary covariates. As often occurs in practice, it is impossible or impractical to measure the exact magnitude of covariates for all subjects in a study. To compensate the missing information, some auxiliary covariates are utilized instead. We propose two easy-to-implement procedures for estimation of regression parameters by making use of auxiliary information. The asymptotic properties of the resulting estimators are established and extensive numerical studies indicate that both procedures work well in practice. 相似文献
19.
ADE-4: a multivariate analysis and graphical display software 总被引:59,自引:0,他引:59
Thioulouse Jean Chessel Daniel Dole´dec Sylvain Olivier Jean-Michel 《Statistics and Computing》1997,7(1):75-83
We present ADE-4, a multivariate analysis and graphical display software. Multivariate analysis methods available in ADE-4 include usual one-table methods like principal component analysis and correspondence analysis, spatial data analysis methods (using a total variance decomposition into local and global components, analogous to Moran and Geary indices), discriminant analysis and within/between groups analyses, many linear regression methods including lowess and polynomial regression, multiple and PLS (partial least squares) regression and orthogonal regression (principal component regression), projection methods like principal component analysis on instrumental variables, canonical correspondence analysis and many other variants, coinertia analysis and the RLQ method, and several three-way table (k-table) analysis methods. Graphical display techniques include an automatic collection of elementary graphics corresponding to groups of rows or to columns in the data table, thus providing a very efficient way for automatic k-table graphics and geographical mapping options. A dynamic graphic module allows interactive operations like searching, zooming, selection of points, and display of data values on factor maps. The user interface is simple and homogeneous among all the programs; this contributes to making the use of ADE-4 very easy for non- specialists in statistics, data analysis or computer science. 相似文献
20.
农业生产风险管理策略的研究 总被引:4,自引:0,他引:4
农业生产经营风险管理所涉及的风险因素很多,主要有:(1)单产变化;(2)价格变化;(3)新技术或新知识变化;(4)农业投入水平变化;(5)政府政策变化;(6)法律变化;(7)消费者偏好变化,等等。通过权衡风险和收益,采用适宜的管理策略来规避风险,提高收益,形成了一系列非确定性关系下的风险决策方法。联系河北省20世纪90年代以来农业生产的实际情况,探讨了各种主要的规避或减少农业生产风险的方法和策略,如利用偏相关系数最小的方法选择稳定的生产项目;采用多种经营以分散风险的组合策略;提高农业生产经营灵活性的诸多措施;利用二次规划以建立风险最小而又能保证一定收入水平的最优规划方法等。 相似文献