Three-stage designs for monitoring clinical trials

Optimal three-stage designs with equal sample sizes at each stage are presented and compared to fixed sample designs, fully sequential designs, designs restricted to use the fixed sample critical value at the final stage, and to modifications of other group sequential designs previously proposed in the literature. Typically, the greatest savings realized with interim analyses are obtained by the first interim look. More than 50% of the savings possible with a fully sequential design can be realized with a simple two-stage design. Three-stage designs can realize as much as 75% of the possible savings. Without much loss in efficiency, the designs can be modified so that the critical value at the final stage equals the usual fixed sample value while maintaining the overall level of significance, alleviating some potential confusion should a final stage be necessary. Some common group sequential designs, modified to allow early acceptance of the null hypothesis, are shown to be nearly optimal in some settings while performing poorly in others. An example is given to illustrate the use of several three-stage plans in the design of clinical trials.     

A plug-in technique in nonparametric regression with dependence

The problem addressed is that of smoothing parameter selection in kernel nonparametric regression in the fixed design regression model with dependent noise. An asymptotic expression of the optimum bandwidth parameter has been obtained in recent studies, where this takes the form h = C ₀ n ^?1/5. This paper proposes to use a plug-in methodology, in order to obtain an optimum estimation of the bandwidth parameter, through preliminary estimation of the unknown value of C ₀.     

On some probability distributions associated with random walks

The probability distribution of the total number of games to ruin in a gambler's ruin random walk with initial position n, the probability distribution of the total size of an epidemic starting with n cases and the probability distribution of the number of customers served during a busy period M/M/1 when the service starts with n waiting customers are identical. All these can be easily obtained by using Lagrangian expansions instead of long combinatorial methods. The binomial, trinomial, quadrinomial and polynomial random walks of a particle have been considered with an absorbing barrier at 0 when the particle starts its walks from a point n, and the pgfs. and the probability distributions of the total number of jumps (trials) before absorption at 0 have been obtained. The values for the mean and variance of such walks have also been given.     

Using power transformations when approximating quantiles

Estimators are obtained tor quantiles of survival distributions. This is accomplished by approximating Lritr distribution of the transtorrneri data, where the transformation used is that of Box and Cox (1964). The normal approximation as in Box and Cox and, in addition, the extreme value approximation are considered. More generally, to use the methods given, the approximating distribution must come from a location-scale family. For some commonly used survival random variables T the performance of the above approximations are evaluated in terms of the ratio of the true quantiles of T to the estimated one, in the long run. This performance is also evaluated for lower quantiles using simulated lognormai, Weibull and gamma data. Several examples are given to illustrate the methodology herein, including one with actual data.     

Bayesian analysis of a multiple-recapture model

In the Bayesian analysis of a multiple-recapture census, different diffuse prior distributions can lead to markedly different inferences about the population size N. Through consideration of the Fisher information matrix it is shown that the number of captures in each sample typically provides little information about N. This suggests that if there is no prior information about capture probabilities, then knowledge of just the sample sizes and not the number of recaptures should leave the distribution of Nunchanged. A prior model that has this property is identified and the posterior distribution is examined. In particular, asymptotic estimates of the posterior mean and variance are derived. Differences between Bayesian and classical point and interval estimators are illustrated through examples.     

The periodogram regression:correction and comments

Ratios of periodogram and spectral density at different harmonic frequencies are independent if the frequency zero is approached slowly enough. This is an asymptotically relevant condition for the periodogram regression to work with fractionally integrated series. In finite samples, however, this theoretical condition should be ignored as we illustrate experimentally.     

Weighted bivariate logarithmic series distributions

In this paper, we are interested in the weighted distributions of a bivariate three parameter logarithmic series distribution studied by Kocherlakota and Kocherlakota (1990). The weighted versions of the model are derived with weight W(x,y) = x^[r] y^[s]. Explicit expressions for the probability mass function and probability generating functions are derived in the case r = s = l. The marginal and conditional distributions are derived in the general case. The maximum likelihood estimation of the parameters, in both two parameter and three parameter cases, is studied. A procedure for computer generation of bivariate data from a discrete distribution is described. This enables us to present two examples, in order to illustrate the methods developed, for finding the maximum likelihood estimates.     

Estimation of a process capability index for inverse gaussian distribution

In this article, interval estimates of Clements' process capability index are studied through bootstrapping when the underlying distribution is Inverse Gaussian. The standard bootstrap, the percentile bootstrap, and the bias-corrected percentile bootstrap confidence intervals are compared.