Inferring gene regulatory networks by an order independent algorithm using incomplete data sets

Analyzing incomplete data for inferring the structure of gene regulatory networks (GRNs) is a challenging task in bioinformatic. Bayesian network can be successfully used in this field. k-nearest neighbor, singular value decomposition (SVD)-based and multiple imputation by chained equations are three fundamental imputation methods to deal with missing values. Path consistency (PC) algorithm based on conditional mutual information (PCA–CMI) is a famous algorithm for inferring GRNs. This algorithm needs the data set to be complete. However, the problem is that PCA–CMI is not a stable algorithm and when applied on permuted gene orders, different networks are obtained. We propose an order independent algorithm, PCA–CMI–OI, for inferring GRNs. After imputation of missing data, the performances of PCA–CMI and PCA–CMI–OI are compared. Results show that networks constructed from data imputed by the SVD-based method and PCA–CMI–OI algorithm outperform other imputation methods and PCA–CMI. An undirected or partially directed network is resulted by PC-based algorithms. Mutual information test (MIT) score, which can deal with discrete data, is one of the famous methods for directing the edges of resulted networks. We also propose a new score, ConMIT, which is appropriate for analyzing continuous data. Results shows that the precision of directing the edges of skeleton is improved by applying the ConMIT score.     

Detection of a changepoint,a mean-shift accompanied with a trend change,in short time-series with autocorrelation

In this study, a changepoint model, which can detect either a mean shift or a trend change when accounting for autocorrelation in short time-series, was investigated with simulations and a new method is proposed. The changepoint hypotheses were tested using a likelihood ratio test. The test statistic does not follow a known distribution and depends on the length of the time-series and the autocorrelation. The results imply that it is not possible to detect autocorrelation and that the estimate of the autocorrelation parameter is biased. It is therefore recommended to use critical values from the empirical distribution for a fixed autocorrelation.     

A monte carlo study on the robustness of the two-sample sequential t test

The robustness of the two-sample sequentla1 t test was studied against departures from normality and equality of variances The effect of skewness and kurtosis of the underlying distribution on the test 1s relatively mild but the effect of heteroscedasticity serious.     

Permutation Test for Equality of Individual an Eigenvalue from a Covariance Matrix in High-Dimension

A test statistic for examining the equality of an individual eigenvalue in two populations of high dimension is proposed. The asymptotic distribution of the proposed statistic is derived and the validity of the permutation test is discussed. Simulations were used to investigate the power of the suggested statistic. The proposed statistic is applied to hand measurement data on white and aboriginal Australians to test the equality of the eigenvalues.     

体育院系术课技能考核若干问题的指导思想和原则

根据《课程纲要》精神 ,结合体育院系专业术课教学实际 ,提出了确定术课技能考核内容、考核形式的有关指导思想和原则 ,对于深化体育院系术课教学改革、促进学生术课技能能力的提高具有一定意义     

Sur la convergence des tests de Schlee et de Yatchew

L'auteur adapte l'approche de Schlee (1980) et de Yatchew (1992) à la construction de deux tests de convexité pour une fonction de régression dans un modèle non paramétrique. Il établit de nouveaux résultats de convergence pour ces tests et étudie leur comportement dans de petits échantillons à l'aide de simulations.     

Improved testing for the binomial distribution using chi-squared components with data-dependent cells

A power study suggests that a good test of fit analysis for the binomial distribution is provided by a data-dependent Chernoff–Lehmann X ² test with class expectations greater than unity, and its components. These data-dependent statistics involve arithmetically simple parameter estimation, convenient approximate distributions and provide a comprehensive assessment of how well the data agree with a binomial distribution. We suggest that a well-performed single test of fit statistic is the Anderson–Darling statistic.     

Model selection and parameter estimation of a multinomial logistic regression model

In the multinomial regression model, we consider the methodology for simultaneous model selection and parameter estimation by using the shrinkage and LASSO (least absolute shrinkage and selection operation) [R. Tibshirani, Regression shrinkage and selection via the LASSO, J. R. Statist. Soc. Ser. B 58 (1996), pp. 267–288] strategies. The shrinkage estimators (SEs) provide significant improvement over their classical counterparts in the case where some of the predictors may or may not be active for the response of interest. The asymptotic properties of the SEs are developed using the notion of asymptotic distributional risk. We then compare the relative performance of the LASSO estimator with two SEs in terms of simulated relative efficiency. A simulation study shows that the shrinkage and LASSO estimators dominate the full model estimator. Further, both SEs perform better than the LASSO estimators when there are many inactive predictors in the model. A real-life data set is used to illustrate the suggested shrinkage and LASSO estimators.     

Testing for markov process vs semi-markov process

Here we have obtained a non-parametric test for testing the null hypothesis H₀ that the given realization is from a Markov process against the alternative hypothesis H₁ that it is from a semi-Markov process with the transition rate monotone increasing (or decreasing). We have shown that the test criterion has normal distribution asymptotically, and the test is consistent and unbiased.