Inference for serological surveys investigating past exposures to infections resulting in long-lasting immunity – an approach using finite mixture models with concomitant information

This paper is concerned with developing a latent class mixture modelling technique which efficiently exploits data from serological surveys aiming to investigate past exposures to infections resulting in long-term or life-lasting immunity. Mixture components featured by antibody assays’ distribution are associated with the serological groups in the population, whilst the probability mixture that an individual belongs to the positive serological group is regarded as an age-dependent prevalence. The latter embeds a mechanistic model which explains the infection process, accounting for heterogeneities, contact patterns in the population and incorporating elements of study design. A Bayesian framework for statistical inference using Markov chain Monte Carlo estimation methods naturally accommodates missing responses in the data and allows straightforward assessement of uncertainties in nonlinear models. The applicability of the method is illustrated by investigating past exposure to varicella zoster virus infection in pre-school children, using data from a large scale UK cohort study which included a cross-sectional serological survey based on oral fluid samples.     

Erectile dysfunction is a marker for obstructive sleep apnea

Purpose: To investigate the prevalence of erectile dysfunction (ED) in patients with obstructive sleep apnea (OSA) with and without any other comorbidities.

Methods: The patient group was newly diagnosed as having OSA (apnea–hypopnea index [AHI]?>?5/h) using a polysomnographic examination. A group of subjects with simple snoring were included into the control group. Clinically relevant comorbidities were systematically assessed in face-to-face interviews. All patients were asked to complete the 15-item International Index of Erectile Function (IIEF-15) questionnaire for the evaluation of ED. The patients with OSA and ED were evaluated according to these comorbidities.

Results: Of the 94 patients, 39 patients were excluded because of severe diseases. OSA was observed in 38 (69.1%) of the 55 patients. ED was seen in 24 (63.2%) patients with OSA, and in 8 (47.1%) patients without OSA (p?>?0.05). There were no statistical differences between the groups’ ages, IIEF scores, and body mass index (BMI) scores. There were statistically significant differences between the groups’ AHI scores (p?p?Conclusion: The rate of ED was higher in patients with OSA who had no other comorbidities. Therefore, ED can be a sensitive marker of OSA.     

当代汉语新词语流行性探

当代汉语新词语的流行性具体表现为:新造词、外来词、行业词、网络词和方言词。新词语能够流行的根本原因在于,时代与社会迅猛发展的必然要求和语言系统内部自我调节的客观需要。对待当代汉语新词语的流行性应持平和心态,全面客观分析新词语的流行性,科学合理规范流行性的新词语。     

Bayesian analysis of screening data: Application to AIDS in blood donors

The rapid increase in the number of AIDS cases during the 1980s and the spread of the disease from the high-risk groups into the general population has created widespread concern. In particular, assessing the accuracy of the screening tests used to detect antibodies to the HIV (AIDS) virus in donated blood and determining the prevalance of the disease in the population are fundamental statistical problems. Because the prevalence of AIDS varies widely by geographic region and data on the number of infected blood donors are published regularly, Bayesian methods, which utilize prior results and update them as new data become available, are quite useful. In this paper we develop a Bayesian procedure for estimating the prevalence of a rare disease, the sensitivity and specificity of the screening tests, and the predictive value of a positive or negative screening test. We apply the procedure to data on blood donors in the United States and in Canada. Our results augment those described in Gastwirth (1987) using classical methods. Indeed, we show that the inclusion of sound prior knowledge into the statistical analysis does not yield sufficiently precise estimates of the predictive value of a positive test. Hence confirmatory testing is needed to obtain reliable estimates. The emphasis of the Bayesian predictive paradigm on prediction intervals for future data yields a valuable insight. We demonstrate that using them might have detected a decline in the specificity of the most frequently used screening test earlier than it apparently was.     

中国信息化的发展进程

从信息化问题的提出及国家信息化管理体制的建立、中国信息化现状、水平测试和中国部分省市信息化发展三个方面阐述了中国信息化的发展进程     

Gendered gambling domains and changes in Sweden

Pachinko is an ‘amusement arcade’ type machine that is popular throughout Japan, with an estimated 17.1 million ‘players’ providing an enormous annual revenue of 2.87 trillion yen (US$250 billion). It is simple and easy to play and has all the hallmarks and structural features of gaming machines worldwide. While academic discourses on the addictive potential of gaming machines are well developed, their application to pachinko is very limited. This is, perhaps, due to a number of factors. First, pachinko is portrayed as a game rather than as gambling in Japan, so that addiction issues are ignored or downplayed. Second, most accounts of ‘playing’ pachinko are journalistic rather than academic. Third, academics tend to focus on police corruption and organized crime rather than addiction. Here, we take the approach that pachinko represents ‘gambling by proxy’ and explore its addictive potential. We conclude that unless pachinko is recognized as a form of gambling, present changes in Japanese legislation will be of limited value in tackling addiction.     

Prevalence of gambling problems among adolescents in the Nordic countries: an overview of national gambling surveys 1997–2009

Kristiansen S, Jensen SM. Prevalence of gambling problems among adolescents in the Nordic countries: an overview of national gambling surveys 1997–2009 Int J Soc Welfare 2011: 20: 75–86 © 2009 The Author(s), Journal compilation © 2009 Blackwell Publishing Ltd and the International Journal of Social Welfare. The study presents an overview of prevalence studies focusing on problem and pathological gambling among adolescent populations in the Nordic countries. Past‐year prevalence of problem gambling among adolescents in the Nordic countries ranges from 0.4 per cent (Denmark) to 4.2 per cent (Sweden). Past‐year prevalence of pathological gambling ranges from 0.1 per cent (Denmark) to 1.76 per cent (Norway). Results from the Nordic countries also show that boys gamble more than girls, older adolescents gamble more than younger adolescents and that, as shown in adult prevalence surveys, problem gambling is more widespread among adolescents than among adults. It is concluded that investigations of gambling problems among adolescents in the Nordic countries differ regarding age groups, sampling procedures, response rates, nomenclature and screening instruments, all of which complicates valid comparisons. More collaboration between researchers from different countries is urged in order to improve comparability between national studies.     

Subjective Sexual Well-Being in a Web Sample of Heterosexual Norwegians

ABSTRACT

The aim of this study was to describe and analyze subjective sexual well-being in terms of emotional and cognitive evaluation of the individual's sexual function in adult Norwegians. The results from this study are based on 1,671 Web interviews among 18- to 67-year-olds randomly selected from Synovate's eBase. A total of 4,285 persons in the Web panel were asked to participate, yielding a response-rate of 39%. The results showed that sexual well-being decreased with increasing age and the number of years married or cohabiting. Young women were more satisfied than young men, and older men were more satisfied than older women. The presence of sexual problems heavily inflicted sexual well-being, as well as living with a partner or not. Subjective sexual well-being was also related to the person's habitualized negative or positive thinking about oneself. In a therapeutic context, restoring sexual function and increasing the client's self-esteem may be the way to increased sexual well-being.     

Problem Gambling and its Impact on Families: A Literature Review

This paper offers an overview of the existing literature concerning problem gambling and families and identifies gaps in current research knowledge on this topic. Relevant theoretical perspectives are outlined and the role of familial factors in the development of problem gambling is discussed. This is followed by a focused review of the effects of problem gambling on family members, specifically the spouse, children and parents. Available treatments and therapies for family members are also reviewed. The paper concludes by identifying the limitations of existing knowledge and some directions for future research on this topic.     

Sleep Quality and Body Mass Index in College Students: The Role of Sleep Disturbances

Abstract

Objective: Obesity and its comorbidities have emerged as a leading public health concern. The aim of this study was to explore the relationship between body mass index (BMI) and sleep patterns, including duration and disturbances. Methods: A convenience sample of 515 college students completed an online survey consisting of the Pittsburgh Sleep Quality Index (PSQI), and self-reported height and weight to calculate BMI. Univariate and multivariate logistic regression analyses were performed using components of the PSQI as predictors of overweight (BMI ≥ 25). Results: One-third of the participants had BMI ≥ 25, and 51% were poor-quality sleepers (PSQI > 5). Controlling for age and sex, only sleep disturbances were associated with overweight (odds ratio = 1.66, 95% confidence interval [1.08, 2.57]). Conclusions: Sleep disturbances, rather than sleep duration, predicted overweight among young adults; this is consistent with the most recent evidence in the literature. These findings support expanding the scope of wellness programs to promote healthy sleep among students.