Approximate Bayes estimation of the parameters and reliability function of a mixture of two inverse Weibull distributions under Type-2 censoring

The main goal of this paper is to develop the approximate Bayes estimation of the five-dimensional vector of the parameters and reliability function of a mixture of two inverse Weibull distributions (MTIWD) under Type-2 censoring. Usually, the posterior distribution is complicated under the scheme of Type-2 censoring and the integrals that are involved cannot be obtained in a simple explicit form. In this study, we use Lindley's [Approximate Bayesian method, Trabajos Estadist. 31 (1980), pp. 223–237] approximate form of Bayes estimation in the case of an MTIWD under Type-2 censoring. Later, we calculate the estimated risks (ERs) of the Bayes estimates and compare them with the corresponding ERs of the maximum-likelihood estimates through Monte Carlo simulation. Finally, we analyse a real data set using the findings.     

Quantal Risk Assessment Database: A Database for Exploring Patterns in Quantal Dose‐Response Data in Risk Assessment and its Application to Develop Priors for Bayesian Dose‐Response Analysis

Quantitative risk assessments for physical, chemical, biological, occupational, or environmental agents rely on scientific studies to support their conclusions. These studies often include relatively few observations, and, as a result, models used to characterize the risk may include large amounts of uncertainty. The motivation, development, and assessment of new methods for risk assessment is facilitated by the availability of a set of experimental studies that span a range of dose‐response patterns that are observed in practice. We describe construction of such a historical database focusing on quantal data in chemical risk assessment, and we employ this database to develop priors in Bayesian analyses. The database is assembled from a variety of existing toxicological data sources and contains 733 separate quantal dose‐response data sets. As an illustration of the database's use, prior distributions for individual model parameters in Bayesian dose‐response analysis are constructed. Results indicate that including prior information based on curated historical data in quantitative risk assessments may help stabilize eventual point estimates, producing dose‐response functions that are more stable and precisely estimated. These in turn produce potency estimates that share the same benefit. We are confident that quantitative risk analysts will find many other applications and issues to explore using this database.     

Bayesian sample size determination for phase IIA clinical trials using historical data and semi‐parametric prior's elicitation

The Simon's two‐stage design is the most commonly applied among multi‐stage designs in phase IIA clinical trials. It combines the sample sizes at the two stages in order to minimize either the expected or the maximum sample size. When the uncertainty about pre‐trial beliefs on the expected or desired response rate is high, a Bayesian alternative should be considered since it allows to deal with the entire distribution of the parameter of interest in a more natural way. In this setting, a crucial issue is how to construct a distribution from the available summaries to use as a clinical prior in a Bayesian design. In this work, we explore the Bayesian counterparts of the Simon's two‐stage design based on the predictive version of the single threshold design. This design requires specifying two prior distributions: the analysis prior, which is used to compute the posterior probabilities, and the design prior, which is employed to obtain the prior predictive distribution. While the usual approach is to build beta priors for carrying out a conjugate analysis, we derived both the analysis and the design distributions through linear combinations of B‐splines. The motivating example is the planning of the phase IIA two‐stage trial on anti‐HER2 DNA vaccine in breast cancer, where initial beliefs formed from elicited experts' opinions and historical data showed a high level of uncertainty. In a sample size determination problem, the impact of different priors is evaluated.     

Bayesian analysis of multivariate survival data using Monte Carlo methods

This paper deals with the analysis of multivariate survival data from a Bayesian perspective using Markov-chain Monte Carlo methods. The Metropolis along with the Gibbs algorithm is used to calculate some of the marginal posterior distributions. A multivariate survival model is proposed, since survival times within the same group are correlated as a consequence of a frailty random block effect. The conditional proportional-hazards model of Clayton and Cuzick is used with a martingale structured prior process (Arjas and Gasbarra) for the discretized baseline hazard. Besides the calculation of the marginal posterior distributions of the parameters of interest, this paper presents some Bayesian EDA diagnostic techniques to detect model adequacy. The methodology is exemplified with kidney infection data where the times to infections within the same patients are expected to be correlated.     

转型经济体制下创业团队的先前经验、无力感与适应能力

在资源依赖理论的基础上,从创业团队的先前经验出发,通过分析4家高科技创业企业的案例资料,考察了创业团队无力感与适应能力之间的关联性,并分析了创业团队的认知趋同性对该作用过程的影响机制,从而为新创企业提高在动态环境中的生存能力提供建议.研究表明,创业团队先前经验可以降低团队成员的无力感,从而提升团队的适应能力,且当创业团队认知趋同性越高时,无力感与适应能力的负向作用越强.     

引入信息成本的信息结构与股权融资成本

本文放松了Easley和O’Hara信息成本为0的假设,在他们的信息结构模型的理论框架下,构建了一个引入信息成本因素的信息结构模型。从信息结构的四个方面：信息成本、信息风险、信息披露的质量和先验信息质量研究了信息结构与股权融资成本之间的关系,得出了四个推论,从而拓展了信息结构模型。在进一步的实证研究中,选取市场微观结构理论中的逆向选择成本、知情交易概率-PIN分别作为信息成本和信息风险的衡量指标,研究发现：信息成本与股权融资成本之间呈倒‘U’型曲线关系;信息风险越高的股票股权融资成本越高;信息披露质量越高的公司,股权融资成本越低;先验信息质量越高,股权融资成本越低;从而对推论进行了有效验证。本文与Easley和O’Hara最大不同在于引入了信息成本因素,并且用实证方法对推论进行了验证,具有一定的开创性。     

Restricted most powerful Bayesian tests for linear models

Uniformly most powerful Bayesian tests (UMPBTs) are a new class of Bayesian tests in which null hypotheses are rejected if their Bayes factor exceeds a specified threshold. The alternative hypotheses in UMPBTs are defined to maximize the probability that the null hypothesis is rejected. Here, we generalize the notion of UMPBTs by restricting the class of alternative hypotheses over which this maximization is performed, resulting in restricted most powerful Bayesian tests (RMPBTs). We then derive RMPBTs for linear models by restricting alternative hypotheses to g priors. For linear models, the rejection regions of RMPBTs coincide with those of usual frequentist F‐tests, provided that the evidence thresholds for the RMPBTs are appropriately matched to the size of the classical tests. This correspondence supplies default Bayes factors for many common tests of linear hypotheses. We illustrate the use of RMPBTs for ANOVA tests and t‐tests and compare their performance in numerical studies.     

Bayesian inference for the randomly censored Weibull distribution

In this paper, we consider the Bayesian inference of the unknown parameters of the randomly censored Weibull distribution. A joint conjugate prior on the model parameters does not exist; we assume that the parameters have independent gamma priors. Since closed-form expressions for the Bayes estimators cannot be obtained, we use Lindley's approximation, importance sampling and Gibbs sampling techniques to obtain the approximate Bayes estimates and the corresponding credible intervals. A simulation study is performed to observe the behaviour of the proposed estimators. A real data analysis is presented for illustrative purposes.     

Bayesian composite quantile regression

One advantage of quantile regression, relative to the ordinary least-square (OLS) regression, is that the quantile regression estimates are more robust against outliers and non-normal errors in the response measurements. However, the relative efficiency of the quantile regression estimator with respect to the OLS estimator can be arbitrarily small. To overcome this problem, composite quantile regression methods have been proposed in the literature which are resistant to heavy-tailed errors or outliers in the response and at the same time are more efficient than the traditional single quantile-based quantile regression method. This paper studies the composite quantile regression from a Bayesian perspective. The advantage of the Bayesian hierarchical framework is that the weight of each component in the composite model can be treated as open parameter and automatically estimated through Markov chain Monte Carlo sampling procedure. Moreover, the lasso regularization can be naturally incorporated into the model to perform variable selection. The performance of the proposed method over the single quantile-based method was demonstrated via extensive simulations and real data analysis.