Performance of traditional f tests in repeated measures designs under covariance heterogeneity

This study investigates the performance of two traditional F tests, one for main effects and the other for interaction in repeated measures designs under several conditions of covariance heterogeneity. Overall, the test for interaction is more vulnerable than the one for main effects. Distortion in the level of significance is less serious for the case of equal group size.     

A Class of Sampling Two Units with Probability Proportional to Size

A class of sampling two units without replacement with inclusion probability proportional to size is proposed in this article. Many different well known probability proportional to size sampling designs are special cases from this class. The first and second inclusion probabilities of this class satisfy important properties and provide a non-negative variance estimator of the Horvitz and Thompson estimator for the population total. Suitable choice for the first and second inclusion probabilities from this class can be used to reduce the variance estimator of the Horvitz and Thompson estimator. Comparisons between different proportional to size sampling designs through real data and artificial examples are given. Examples show that the minimum variance of the Horvitz and Thompson estimator obtained from the proposed design is not attainable for the most cases at any of the well known designs.     

Counterexamples in unbalanced two-way analysis of variance

Recommended methods for analyzing unbalanced two-way data may be classified into two major categories:the parametric interpretation approach and the model comparison approach. Each approach has its advantages and its drawbacks. The main drawback of the parametric interpretation approach is non-orthogonality.For the model comparison approach the main drawback is the dependence of the hypothesis tested on the cell sizes. In this paper we provide examples to illustrate these drawbacks.     

Exponential tilt models for two-group comparison with censored data

We study application of the Exponential Tilt Model (ETM) to compare survival distributions in two groups. The ETM assumes a parametric form for the density ratio of the two distributions. It accommodates a broad array of parametric models such as the log-normal and gamma models and can be sufficiently flexible to allow for crossing hazard and crossing survival functions. We develop a nonparametric likelihood approach to estimate ETM parameters in the presence of censoring and establish related asymptotic results. We compare the ETM to the Proportional Hazards Model (PHM) in simulation studies. When the proportional hazards assumption is not satisfied but the ETM assumption is, the ETM has better power for testing the hypothesis of no difference between the two groups. And, importantly, when the ETM relation is not satisfied but the PHM assumption is, the ETM can still have power reasonably close to that of the PHM. Application of the ETM is illustrated by a gastrointestinal tumor study.     

Covariate Selection for the Semiparametric Additive Risk Model

Abstract.  This paper considers covariate selection for the additive hazards model. This model is particularly simple to study theoretically and its practical implementation has several major advantages to the similar methodology for the proportional hazards model. One complication compared with the proportional model is, however, that there is no simple likelihood to work with. We here study a least squares criterion with desirable properties and show how this criterion can be interpreted as a prediction error. Given this criterion, we define ridge and Lasso estimators as well as an adaptive Lasso and study their large sample properties for the situation where the number of covariates p is smaller than the number of observations. We also show that the adaptive Lasso has the oracle property. In many practical situations, it is more relevant to tackle the situation with large p compared with the number of observations. We do this by studying the properties of the so-called Dantzig selector in the setting of the additive risk model. Specifically, we establish a bound on how close the solution is to a true sparse signal in the case where the number of covariates is large. In a simulation study, we also compare the Dantzig and adaptive Lasso for a moderate to small number of covariates. The methods are applied to a breast cancer data set with gene expression recordings and to the primary biliary cirrhosis clinical data.     

Parameter estimation in nonlinear regression models 1

Fisher information contained in record values, inter-record times and their concomitants from a sample of fixed size is derived in general and explicit expressions are deduced for some specific known bivariate classes of distributions. A comparison between fixed sampling and inverse sampling schemes with equal number of records and concomitants is also carried out. We also consider parameter estimation based on bivariate records and a small simulation study is done.     

Hypothesis Testing of Hazard Ratio Parameters in Marginal Models for Multivariate Failure Time Data

Marginal hazard models for multivariate failure time data have been studied extensively in recent literature. However, standard hypothesis test statistics based on the likelihood method are not exactly appropriate for this kind of model. In this paper, extensions of the three commonly used likelihood hypothesis test statistics are discussed. Generalized Wald, generalized score and generalized likelihood ratio tests for hazard ratio parameters in a marginal hazard model for multivariate failure time data are proposed and their asymptotic distributions examined. The finite sample properties of these statistics are studied through simulations. The proposed method is applied to data from Busselton Population Health Surveys.     

Choice of Parametric Accelerated Life and Proportional Hazards Models for Survival Data: Asymptotic Results

We discuss the impact of misspecifying fully parametric proportional hazards and accelerated life models. For the uncensored case, misspecified accelerated life models give asymptotically unbiased estimates of covariate effect, but the shape and scale parameters depend on the misspecification. The covariate, shape and scale parameters differ in the censored case. Parametric proportional hazards models do not have a sound justification for general use: estimates from misspecified models can be very biased, and misleading results for the shape of the hazard function can arise. Misspecified survival functions are more biased at the extremes than the centre. Asymptotic and first order results are compared. If a model is misspecified, the size of Wald tests will be underestimated. Use of the sandwich estimator of standard error gives tests of the correct size, but misspecification leads to a loss of power. Accelerated life models are more robust to misspecification because of their log-linear form. In preliminary data analysis, practitioners should investigate proportional hazards and accelerated life models; software is readily available for several such models.     

反命名和戏谑式命名——杨绛散文的反讽修辞

杨绛散文的反讽修辞对应着两个语境 :故事发生时的语境 ( 5 0年代初至 70年代初 )和故事写作时的语境 ( 80 - 90年代 )。她将“陪斗者”这一政治身份转化为叙述人的观察和言说视角 ,通过“反命名和戏谑式命名”的修辞方式 (表现为“我不是…”/“我是…”的语式 ) ,实现了对语境限制的反限制 ,构成了一种“互文本”的深层意义结构。其戏谑式命名的常用方式是“贬低陈述”。作为女性写作 ,杨绛选择反讽作为自己散文的基本修辞方式 ,既是时间的积累沉淀对她的话语启示 ,也是她对自己文化素质审美心智优长的一种发挥     

知识经济时代的人性假定与图书馆的使命管理

从知识经济时代的人性假定的角度,阐述了人性假定在图书馆人力资源管理的关系,并论述了图书馆管理中结合人性假定融入"使命管理"这一新的管理理念的意义和现实性策略,指出知识经济时代的图书馆贯彻"以人为本"的管理理念,在管理中要渗透人文关怀,尊重人的个性,重视人的价值。