Urn Sampling and the Proportional Hazard Model

This paper investigates the urn sampling analogue for the score statistic relating survival to covariates assuming a proportional hazard model. The exact permutation distribution can be calculated as well as the exact low order moments for arbitrary censoring patterns. The asymptotic distribution of the score statistic is an easy consequence. The method is naturally extended to deal with the multivariate case, time varying covariates and interval censoring. Finally the relationship between the censoring process, the survival times and covariates are studied considering different reference sets for the distribution of the score statistic. Some assumptions about the censoring process are investigated and as a consequence the effect of censoring is clarified.     

Emergency Planning for Hazardous Industrial Areas: A Brazilian Case Study

One of the characteristics of modern industrial development is the emergence of a new typology of accidents whose effects can be spread, in space as well as in time, well beyond the borders of the installations where they occur, sometimes impacting the local population and the environment in a catastrophic fashion. This is the result of a number of factors that have changed the risk profile of modern industrial activities. For a number of reasons, the developing countries have proved to be more vulnerable to industrial disasters. Three of the most catastrophic industrial accidents—Bhopal, San Juan de Ixhuatepec, and Cubatão—occurred in developing countries, claiming thousands of lives. During the 1970s and 1980s the higher degree of public visibility of industrial hazards as a result of serious accidents, led to the creation, especially in the more industrialized countries, of regulations for greater control over industrial activities, either by means of new laws or by updating existing legislation. Some of these regulations were designed to improve the response to accidents with potential impacts outside the industrial sites. This article attempts to describe the current status and identify the shortcomings of off‐site emergency planning for hazardous industrial areas in Brazil. The most important problems are the lack of specific legislation and the absence of awareness and active participation of public authorities. The experience of an off‐site emergency planning process for a Brazilian industrial area is presented. This experience illustrates how difficult it is to prepare and implement emergency planning processes in an industrializing country.     

Calculating the power or sample size for the logistic and proportional hazards models

An algorithm is presented for calculating the power for the logistic and proportional hazards models in which some of the covariates are discrete and the remainders are multivariate normal. The mean and covariance matrix of the multivariate normal covariates may depend on the discrete covariates.

The algorithm, which finds the power of the Wald test, uses the result that the information matrix can be calculated using univariate numerical integration even when there are several continuous covariates. The algorithm is checked using simulation and in certain situations gives more accurate results than current methods which are based on simple formulae. The algorithm is used to explore properties of these models, in particular, the power gain from a prognostic covariate in the analysis of a clinical trial or observational study. The methods can be extended to determine power for other generalized linear models.     

Stochastic comparisons of order statistics,with applications in relibility

This paper reviews recent developments in the stochastic comparison of order statistics. The results discussed are basically: (l) Stochastic comparisons of linear combinations of order statistics from distributions F and G where G^?1 F is convex or starshaped. (2) Stochastic comparisons of individual order statistics and of vectors of order statistics from underlying heterogeneous distributions by the use of majorization and Schur function theory. (3) Stochastic comparison of random processes. Applications to reliability problems are presented illustrating the use and value of the theoretical results described     

Evaluation of an analysis approach used to account for extra-variation in clustered categorical responses

This article presents the results of a simulation study investigating the performance of an approach developed by Miller and Landis (1991) for the analysis of clustered categorical responses. Evaluation of this “two-step” approach, which utilizes the method of moments to estimate the extra-variation pardmeters and subsequently incorporates these parameters into estimating equations for modelling the marginal expectations, is carried out in an experimental setting involving a comparison between two groups of observations. We assume that data for both groups are collected from each cluster and responses are measured on a three-point ordinal scale. The performance of the estimators used in both “steps” of the analysisis investigated and comparisons are made to an alternative analysismethod that ignores the clustering. The results indicate that in the chosen setting the test for a difference between groups generally operatbs at the nominal α=0.05 for 10 or more clusters and hasincreasing power with both an increasing number of clusters and an inrreasing treatment effect. These results provide a striking contrasc to those obtained from an improper analysis that ignores clustering.     

A class of semiparametric transormation frailty models with application to estimating treatment effects and heterogenity in aids clinical traials

Muitivariate failure time data are common in medical research; com¬monly used statistical models for such correlated failure-time data include frailty and marginal models. Both types of models most often assume pro¬portional hazards (Cox, 1972); but the Cox model may not fit the data well This article presents a class of linear transformation frailty models that in¬cludes, as a special case, the proportional hazards model with frailty. We then propose approximate procedures to derive the best linear unbiased es¬timates and predictors of the regression parameters and frailties. We apply the proposed methods to analyze results of a clinical trial of different dose levels of didansine (ddl) among HIV-infected patients who were intolerant of zidovudine (ZDV). These methods yield estimates of treatment effects and of frailties corresponding to patient groups defined by clinical history prior to entry into the trial.     

Pseudo-bayes estimation of multinomial proportions

In the simultaneous estimation of multinomial proportions, two estimators are developed which incorporate prior means and a prior parameter which reflects the accuracy of the prior means. These estimators possess substantially smaller risk than the standard estimator in a region of the parameter space and are much more robust than the conjugate Bayes estimator with respect to parameter values far from the prior mean. When vague prior information is available, these estimators and confidence regions derived from them appear to be attractive alternatives to the procedures based on the standard estimator.     

Risk Perception, Federal Spending, and the Savannah River Site: Attitudes of Hunters and Fishermen

This paper examines the attitudes of 285 hunters and fishermen from South Carolina about hunting and fishing, risk, environmental issues, and future land use of the Savannah River Site. We test the null hypothesis that there is no difference in hunting and fishing rates, attitudes toward the safety of fish and deer obtained from SRS, attitudes toward future land use at SRS, and perceptions of the severity of environmental problems as a function of how far respondents lived from the site. Respondents hunted or fished an average of over 40 days a year, and only half felt that the fish and deer from SRS were safe to eat. Willingness to expend federal funds was correlated with perceptions of the severity of the problem. Preferences for future land use at SRS fell into three categories: high (environmental research park, hunting, fishing, camping), medium (nuclear production, factories, preserve only), and low (nuclear waste storage, residential). There were no differences in hunting and fishing rates, ranking of the severity of environmental problems, and willingness to expend federal funds as a function of distance of residence from SRS, but attitudes toward future land use differed significantly as a function of location of residence. Those living close to SRS were more willing to have the site used for factories, residential, nuclear material production and to store nuclear wastes than those living farther from the site. Our data on recreational rates, attitudes toward future land use, and willingness to expend federal funds to solve environmental problems reiterate the importance of assessing stakeholder attitudes toward decisions regarding future land use at DOE sites     

论西方审美游戏说的双向演绎

“游戏”语词是现代思想的关键词语,是理解思想、语言和文学的奥秘的通道。西方不同历史阶段对这一概念不同理解导致对他们文学本质的寻求也呈现出历史的变化起伏。从亚里斯多德的娱乐到康德的自由到席勒的生命冲动,从儿童游戏到上帝掷色子到后现代的语言游戏,审美游戏说在西方历史中呈现出有趣的双向演绎和延伸。     

行政法上的比例原则初探

行政法上的比例原则主要包括适当性原则、必要性原则和狭义比例原则三个方面。在德国、法国、美国、日本以及我国台湾地区等行政法治较为发达的国家和地区,比例原则都得到了不同程度的运用,但我国大陆地区对比例原则的运用还局限于自由裁量权领域。