On the bias and variance of some proportion estimators

Providing certain parameters are known, almost any linear map from R^P to R¹ can be adjusted to yield a consistent and unbiased estimator in the context of estimating the mixing proportion θ on the basis of an unclassified sample of observations taken from a mixture of two p-dimensional distributions in proportions θ and 1-θ. Attention is focused on an estimator proposed recently, θ, which has minimum variance over all such linear maps. Unfortunately, the form of θ depends on the means of the component distributions and the covariance matrix of the mixture distribution. The effect of using appropriate sample estimates for these unknown parameters in forming θ is investigated by deriving the asymptotic mean and variance of the resulting estimator. The relative efficiency of this estimator under normality is derived. Also, a study is undertaken of the performance of a similar type of estimator appropriate in the context where an observed data vector is not an observation from either one or the other onent distributions, but is recorded as an integrated measurement over a surface area which is a mixture of two categories whose characteristics have different statistical distributions.The asymptotic bias in this case is compared with some available practical results.     

A semiparametric Bayesian approach to simplex regression model with heterogeneous dispersion

ABSTRACT

Simplex regression model is often employed to analyze continuous proportion data in many studies. In this paper, we extend the assumption of a constant dispersion parameter (homogeneity) to varying dispersion parameter (heterogeneity) in Simplex regression model, and present the B-spline to approximate the smoothing unknown function within the Bayesian framework. A hybrid algorithm combining the block Gibbs sampler and the Metropolis-Hastings algorithm is presented for sampling observations from the posterior distribution. The procedures for computing model comparison criteria such as conditional predictive ordinate statistic, deviance information criterion, and averaged mean squared error are presented. Also, we develop a computationally feasible Bayesian case-deletion influence measure based on the Kullback-Leibler divergence. Several simulation studies and a real example are employed to illustrate the proposed methodologies.     

CLASSIFICATION AND PROPORTION ESTIMATION

Assume that a number of individuals are to be classified into one of two populations and that, at the same time, the proportion of members of each population needs to be estimated. The allocated proportions given by the Bayes classification rule are not consistent estimates of the true proportions, so a different classification rule is proposed; this rule yields consistent estimates with only a small increase in the probability of misclassification. As an illustration, the case of two normal distributions with equal covariance matrices is dealt with in detail.     

Bayesian tests for matched proportions

A sample of n subjects is observed in each of two states, S₁-and S₂. In each state, a subject is in one of two conditions, X or Y. Thus, a subject may be recorded as showing a change if its condition in the two states is ‘Y,X’ or ‘X,Y’ and, otherwise, the condition is unchanged. We consider a Bayesian test of the null hypothesis that the probability of an ‘X,Y’ change exceeds that of a ‘Y,X’ change by amount k_O. That is, we develop the posterior distribution of k_O, the difference between the two probabilities and reject the null hypothesis if k lies outside the appropriate posterior probability interval. The performance of the method is assessed by Monte Carlo and other numerical studies and brief tables of exact critical values are presented     

Methods for one-sided testing of the difference between proportions and sample size considerations related to non-inferiority clinical trials

Assessment of non-inferiority is often performed using a one-sided statistical test through an analogous one-sided confidence limit. When the focus of attention is the difference in success rates between test and active control proportions, the lower confidence limit is computed, and many methods exist in the literature to address this objective. This paper considers methods which have been shown to be popular in the literature and have surfaced in this research as having good performance with respect to controlling type I error at the specified level. Performance of these methods is assessed with respect to power and type I error through simulations. Sample size considerations are also included to aid in the planning stages of non-inferiority trials focusing on the difference in proportions. Results suggest that the appropriate method to use depends on the sample size allocation of subjects in the test and active control groups.     

Testing equality of proportions with incomplete correlated data

Let (ψ_i,φ_i) be independent, identically distributed pairs of zero-one random variables with (possible) dependence of ψ_i and φ_i within the pair. For n pairs, both variables are observed, but for m₁ additional pairs only ψ_i is observed and for m₂ others φ_i is observed. If π_1· = P{ψ_i = 1} and π_·1=P{φ_i, the problem is to test π_1·=π_·1. Maximum likelihood estimates of π_1· and π_·1 are obtained via the EM algorithm. A test statistic is developed whose null distribution is asymptotically chi-square with one degree of freedom (as n and either m₁ or m₂ tend to infinity). If m₁ = m₂ = 0 the statistic reduces to that of McNemar's test; if n = 0, it is equivalent to the statistic for testing equality of two independent proportions. This test is compared with other tests by means of Pitman efficiency. Examples are presented.     

A beta-inflated mean regression model with mixed effects for fractional response variables

Abstract

In this article we propose a new mixed-effects regression model for fractional bounded response variables. Our model allows us to incorporate covariates directly to the expected value, so we can quantify exactly the influence of these covariates in the mean of the variable of interest rather than to the conditional mean. Estimation is carried out from a Bayesian perspective. Due to the complexity of the augmented posterior distribution, we use a Hamiltonian Monte Carlo algorithm, the No-U-Turn sampler, implemented using the Stan software. A simulation study was performed showing that our model has a better performance than other traditional longitudinal models for bounded variables. Finally, we applied our beta-inflated mean mixed-effects regression model to real data which consists of utilization of credit lines in the peruvian financial system.