Repeated measurements designs with unequal period sizes

Summary This paper is concerned with the designs in which each experimental unit is assigned more than once to a treatment, either different or identical. An easy method of constructing balanced minimal repeated measurements designs with unequal period sizes is presented whenever the number of periods is less than the number of treatments. Strongly balanced minimal repeated measurements designs with unequal period sizes are also constructed whenever the number of periods is less than the number of treatments.     

不定次重复的古诺模型博弈及其仿真研究

重复次数不确定的重复博弈比无限次重复博弈更符合客观实际。提出了不定次重复的古诺模型及不同的博弈策略；通过计算机仿真的方法，根据设计的仿真方案对不定次重复的古诺模型博弈过程进行了仿真，得到了不同贴现因子条件下各种仿真方案的厂商得益；对各方案的结果进行了分析比较，得到了统计意义上的临界贴现因子和均衡策略；阐释了仿真结果的输入弹性的概念，并用其分析了不同仿真方案的结果差异的原因。     

A multistate approach for estimating the incidence of human immunodeficiency virus by using data from a prevalent cohort study

Summary.  Cohort studies of individuals infected with the human immunodeficiency virus (HIV) provide useful information on the past pattern of HIV diagnoses, progression of the disease and use of antiretroviral therapy. We propose a new method for using individual data from an open prevalent cohort study to estimate the incidence of HIV, by jointly modelling the HIV diagnosis, the inclusion in the cohort and the progression of the disease in a Markov model framework. The estimation procedure involves the construction of a likelihood function which takes into account the probability of observing the total number of subjects who are enrolled in the cohort and the probabilities of passage through the stages of disease for each observed subject conditionally on being included in the cohort. The estimator of the HIV infection rate is defined as the function which maximizes a penalized likelihood, and the solution of this maximization problem is approximated on a basis of cubic M -splines. The method is illustrated by using cohort data from a hospital-based surveillance system of HIV infection in Aquitaine, a region of south-western France. A simulation study is performed to study the ability of the model to reconstruct the incidence of HIV from prevalent cohort data.     

Marginal Regression for Binary Longitudinal Data in Adaptive Clinical Trials

Abstract.  In an adaptive clinical trial research, it is common to use certain data-dependent design weights to assign individuals to treatments so that more study subjects are assigned to the better treatment. These design weights must also be used for consistent estimation of the treatment effects as well as the effects of the other prognostic factors. In practice, there are however situations where it may be necessary to collect binary responses repeatedly from an individual over a period of time and to obtain consistent estimates for the treatment effect as well as the effects of the other covariates in such a binary longitudinal set up. In this paper, we introduce a binary response-based longitudinal adaptive design for the allocation of individuals to a better treatment and propose a weighted generalized quasi-likelihood approach for the consistent and efficient estimation of the regression parameters including the treatment effects.     

Multiple imputation compared with restricted pseudo‐likelihood and generalized estimating equations for analysis of binary repeated measures in clinical studies

Non‐likelihood‐based methods for repeated measures analysis of binary data in clinical trials can result in biased estimates of treatment effects and associated standard errors when the dropout process is not completely at random. We tested the utility of a multiple imputation approach in reducing these biases. Simulations were used to compare performance of multiple imputation with generalized estimating equations and restricted pseudo‐likelihood in five representative clinical trial profiles for estimating (a) overall treatment effects and (b) treatment differences at the last scheduled visit. In clinical trials with moderate to high (40–60%) dropout rates with dropouts missing at random, multiple imputation led to less biased and more precise estimates of treatment differences for binary outcomes based on underlying continuous scores. Copyright © 2005 John Wiley & Sons, Ltd.     

博弈论框架下的信用缺失探析

运用博弈论探析了我国在完善市场经济中的信用缺失问题 ,认为信用缺失的原因在于经济主体对未来缺乏足够的信心 ,合同 (战略 )的执行机制不力及政府宏观经济政策的动态不一致 ,并据此提出解决措施。     

Parameter Estimation for a Discretely Observed Integrated Diffusion Process

Abstract.  We consider the estimation of unknown parameters in the drift and diffusion coefficients of a one-dimensional ergodic diffusion X when the observation is a discrete sampling of the integral of X at times i Δ , i  =  1 ,…, n . Assuming that the sampling interval tends to 0 while the total length time interval tends to infinity, we first prove limit theorems for functionals associated with our observations. We apply these results to obtain a contrast function. The associated minimum contrast estimators are shown to be consistent and asymptotically Gaussian with different rates for drift and diffusion coefficient parameters.     

Bayesian incorporation of repeated measurements in logistic discrimination

A common problem in medical statistics is the discrimination between two groups on the basis of diagnostic information. Information on patient characteristics is used to classify individuals into one of two groups: diseased or disease-free. This classification is often with respect to a particular disease. This discrimination has two probabilistic components: (1) the discrimination is not without error, and (2) in many cases the a priori chance of disease can be estimated. Logistic models (Cox 1970; Anderson 1972) provide methods for incorporating both of these components. The a posteriori probability of disease may be estimated for a patient on the basis of both current measurement of patient characteristics and prior information. The parameters of the logistic model may be estimated on the basis of a calibration trial. In practice, not one but several sets of measurements of one characteristic of the patient may be made on a questionable case. These measurements typically are correlated; they are far from independent. How should these correlated measurements be used? This paper presents a method for incorporating several sets of measurements in the classification of a case.     

Optimal Prediction in Stochastic Regression Models with Application to the Analysis of Repeated Surveys

Several results relating to the optimal prediction of regression coefficients and random variables under a general linear model with stochastic coefficients are presented. These results are then applied to the analysis of repeated sample surveys over time. In particular, if the finite population can be modelled by a superpopulation model, a fully efficient method for the analysis of repeated surveys is proposed.     

Gambling Reputation: Repeated Bargaining With Outside Options

We study the role of incomplete information and outside options in determining bargaining postures and surplus division in repeated bargaining between a long‐run player and a sequence of short‐run players. The outside option is not only a disagreement point, but reveals information privately held by the long‐run player. In equilibrium, the uninformed short‐run players' offers do not always respond to changes in reputation and the informed long‐run player's payoffs are discontinuous. The long‐run player invokes inefficient random outside options repeatedly to build reputation to a level where the subsequent short‐run players succumb to his extraction of a larger payoff, but he also runs the risk of losing reputation and relinquishing bargaining power. We investigate equilibrium properties when the discount factor goes to 1 and when the informativeness of outside options diffuses. In both cases, bargaining outcomes become more inefficient and the limit reputation‐building probabilities are interior.