Effect of tuberculosis on immune restoration among HIV-infected patients receiving antiretroviral therapy

In this article, time to immune recovery during antiretroviral therapy was estimated and compared between HIV-infected children with and without tuberculosis (TB). CD4?T-cell restoration was used as a criterion for determining immune recovery. The median residual lifetime function, which is more intuitive and robust compared to the frequently used measures of lifetime data, was used to estimate time to CD4?T-cell restoration. The median residual lifetime is not influenced by extreme observations and heavy-tailed distributions which are commonly encountered in clinical studies. Permutation-based methods were used to compare the CD4?T-cell restoration times between the two groups of patients. Our results indicate that children with TB had uniformly higher median residual lifetimes to immune recovery compared to those without TB. Although TB was associated with slower CD4?T-cell restoration, the differences between the restoration times of the two groups were not statistically significant.     

Predictive Hierarchic Modeling of Operational Characteristics in Clinical Trials

An analytic methodology for patient enrollment modeling using a Poisson-gamma model is developed by Anisimov & Fedorov (2005–2007). For modeling hierarchic processes associated with enrollment, a new methodology using evolving stochastic processes is proposed. This provides rather general and unified framework to describe various operational processes associated with enrollment. The technique for calculating predictive distributions, mean, and credibility bounds for evolving processes is developed. Some applications to modeling operational characteristics in clinical trials are considered with focus to modeling events associated with incoming and follow-up patients in different settings. For these models, predictive characteristics are derived in a closed form.     

Elementary renewal theorems for widely dependent random variables with applications to precise large deviations

Abstract

On the basis of Wang and Cheng (J. Math. Anal. Appl. 384 (2011) 597–606), this paper further investigates elementary renewal theorems for counting processes generated by random walks with widely orthant dependent increments. The obtained results improve the corresponding ones of the above-mentioned paper mainly in the sense of weakening the moment conditions on the positive parts of the increments. Meanwhile, a revised version of strong law of large numbers for random walks with widely orthant dependent increments is established, which improves Theorem 1.4 of Wang and Cheng (2011 Wang, Y., and D. Cheng. 2011. Basic renewal theorems for a random walk with widely dependent increments and their applications. Journal of Mathematical Analysis and Applications 384 (2):597–606. doi:10.1016/j.jmaa.2011.06.010.[Crossref], [Web of Science ®] , [Google Scholar]) by enlarging the regions of dominating coefficients. Finally, by using the above results, some precise large deviation results for a nonstandard renewal risk model are established, in which the innovations are widely orthant dependent random variables with common heavy tails, and the inter-arrival times are also widely orthant dependent.     

Transition probabilities and ARL performance of Six Sigma zone control charts

In this article, Six Sigma zone control charts (SSZCCs) are proposed for world class organizations. The transition probabilities are obtained using the Markov chain approach. The Average Run Length (ARL) values are then presented. The ARL performance of the proposed SSZCCs and the standard Six Sigma control chart (SSCC) without zones or run rules is studied. The ARL performance of these charts is then compared with those of the other standard zone control charts (ZCCs), the modified ZCC and the traditional Shewhart control chart (SCC) with common run rules. As expected, it is shown that the proposed SSZCC outperforms the standard SSCC without zones or run rules for process shifts of any magnitude. When compared to the other standard ZCCs and the Shewhart chart with common run rules, it is observed that the proposed SSZCCs have much higher false alarm rates for smaller shifts and hence they prevent unwanted process disturbances. The application of the proposed SSZCC is illustrated using a real time example.     

The beta generalized linear exponential distribution

In this paper, a new five-parameter lifetime distribution called beta generalized linear exponential distribution (BGLED) is introduced. It includes at least 17 popular sub-models as special cases such as the beta linear exponential, the beta generalized exponential, and the exponentiated generalized linear distributions. Mathematical and statistical properties of the proposed distribution are discussed in details. In particular, explicit expression for the density function, moments, asymptotics distributions for sample extreme statistics, and other statistical measures are obtained. The estimation of the parameters by the method of maximum-likelihood is discussed and the finite sample properties of the maximum-likelihood estimators (MLEs) are investigated numerically. A real data set is used to demonstrate its superior performance fit over several existing popular lifetime models.     

Machine Learning Vasicek Model Calibration with Gaussian Processes

In this article, we calibrate the Vasicek interest rate model under the risk neutral measure by learning the model parameters using Gaussian processes for machine learning regression. The calibration is done by maximizing the likelihood of zero coupon bond log prices, using mean and covariance functions computed analytically, as well as likelihood derivatives with respect to the parameters. The maximization method used is the conjugate gradients. The only prices needed for calibration are zero coupon bond prices and the parameters are directly obtained in the arbitrage free risk neutral measure.     

Prediction intervals for farima processes by bootstrap methods

In this paper we introduce a procedure to compute prediction intervals for FARIMA (p d q) processes, taking into account the variability due to model identification and parameter estimation. To this aim, a particular bootstrap technique is developed. The performance of the prediction intervals is then assessed and compared to that of stand­ard bootstrap percentile intervals. The methods are applied to the time series of Nile River annual minima.     

Estimation for a first-order bifurcating autoregressive process with heavy-tail innovations

Asymptotics of an alternative extreme-value estimator for the autocorrelation parameter in a first-order bifurcating autoregressive (BAR) process with non-gaussian innovations are derived. This contrasts with traditional estimators whose asymptotic behavior depends on the central part of the innovation distribution. Within any BAR model, the main concern is addressing the complex dependency between generations. The inability of traditional methods to handle this dependency motivated an alternative procedure. With the combination of an extreme-value approach and a clever blocking argument, the dependency issue within the BAR process was resolved, which in turn allowed us to derive the limiting distribution for the proposed estimator through the use of regular variation and non-stationary point processes. Finally, the implications of our extreme-value approach are discussed with an extensive simulation study that not only assesses the reliability of our proposed estimate but also presents the findings for a new estimator of an unknown location parameter θ and its implications.     

Classical estimation of hazard rate and mean residual life functions of Pareto distribution

Abstract

In this paper we find the maximum likelihood estimates (MLEs) of hazard rate and mean residual life functions (MRLF) of Pareto distribution, their asymptotic non degenerate distribution, exact distribution and moments. We also discuss the uniformly minimum variance unbiased estimate (UMVUE) of hazard rate function and MRLF. Finally, two numerical examples with simulated data and real data set, are presented to illustrate the proposed estimates.     

Exponentiality test based on Renyi distance between equilibrium distributions

ABSTRACT

On the basis of Csiszar's φ-divergence discrimination information, we propose a measure of discrepancy between equilibriums associated with two distributions. Proving that a distribution can be characterized by associated equilibrium distribution, a Renyi distance of the equilibrium distributions is constructed that made us to propose an EDF-based goodness-of-fit test for exponential distribution. For comparing the performance of the proposed test, some well-known EDF-based tests and some entropy-based tests are considered. Based on the simulation results, the proposed test has better powers than those of competing entropy-based tests for the alternatives with decreasing hazard rate function. The use of the proposed test is evaluated in an illustrative example.