电视机自动增益控制电路动态特性测量

本文提出一种电视机自动增益控制电路动态特性简易测量方法.按照此法,只需在待测电视机前加一级可调衰减器,就能用常用电子仪器测出自动增益控制电路的动态特性,并以此为依据改善电视机相关电路的性能.     

Constructing optimal designs for fitting pharmacokinetic models

We consider some computational issues that arise when searching for optimal designs for pharmacokinetic (PK) studies. Special factors that distinguish these are (i) repeated observations are taken from each subject and the observations are usually described by a nonlinear mixed model (NLMM), (ii) design criteria depend on the model fitting procedure, (iii) in addition to providing efficient parameter estimates, the design must also permit model checking, (iv) in practice there are several design constraints, (v) the design criteria are computationally expensive to evaluate and often numerical integration is needed and finally (vi) local optimisation procedures may fail to converge or get trapped at local optima.We review current optimal design algorithms and explore the possibility of using global optimisation procedures. We use these latter procedures to find some optimal designs.For multi-purpose designs we suggest two surrogate design criteria for model checking and illustrate their use.     

一种实用自适应PID控制器

本文介绍了一种实用自适应PID控制器,它是以MCS-51系列单片微机为核心,采用PID控制规律结合参数辨识的控制算法,实现了PID参数完全在线自动整定。该控制器适用于被控制对象未知或慢时变的场合,既可替代常规PID控制器,也可作为分布式系统的低级智能控制器。     

机器人、微机和微处理器(RMM)的抗干扰

本文讨论了电磁辐射、电源波动等干扰源,并分析这些干扰源怎样引起机器人控制系统、微机、微处理器的失灵和损坏。最后本文介绍了防止这些干扰的实用方法,它们包括有双层屏蔽、光电隔离、光纤传导等方法。     

Between stability and higher-order asymptotics

We discuss the effects of model misspecifications on higher-order asymptotic approximations of the distribution of estimators and test statistics. In particular we show that small deviations from the model can wipe out the nominal improvements of the accuracy obtained at the model by second-order approximations of the distribution of classical statistics. Although there is no guarantee that the first-order robustness properties of robust estimators and tests will carry over to second-order in a neighbourhood of the model, the behaviour of robust procedures in terms of second-order accuracy is generally more stable and reliable than that of their classical counterparts. Finally, we discuss some related work on robust adjustments of the profile likelihood and outline the role of computer algebra in this type of research.     

Case–control studies with complex sampling

The use of complex sampling designs in population-based case–control studies is becoming more common, particularly for sampling the control population. This is prompted by all the usual cost and logistical benefits that are conferred by multistage sampling. Complex sampling has often been ignored in analysis but, with the advent of packages like SUDAAN, survey-weighted analyses that take account of the sample design can be carried out routinely. This paper explores this approach and more efficient alternatives, which can also be implemented by using readily available software.     

Adaptive Estimation Using Weighted Least Squares

This paper proposes an adaptive estimator that is more precise than the ordinary least squares estimator if the distribution of random errors is skewed or has long tails. The adaptive estimates are computed using a weighted least squares approach with weights based on the lengths of the tails of the distribution of residuals. Smaller weights are assigned to those observations that have residuals in the tails of long-tailed distributions and larger weights are assigned to observations having residuals in the tails of short-tailed distributions. Monte Carlo methods are used to compare the performance of the proposed estimator and the performance of the ordinary least squares estimator. The estimates that were studied in this simulation include the difference between the means of two populations, the mean of a symmetric distribution, and the slope of a regression line. The adaptive estimators are shown to have lower mean squared errors than those for the ordinary least squares estimators for short-tailed, long-tailed, and skewed distributions, provided the sample size is at least 20. The ordinary least squares estimator has slightly lower mean squared error for normally distributed errors. The adaptive estimator is recommended for general use for studies having sample sizes of at least 20 observations unless the random errors are known to be normally distributed.     

Heteroscedastic Regression Models and Applications to Off-line Quality Control

We discuss in the present paper the analysis of heteroscedastic regression models and their applications to off-line quality control problems. It is well known that the method of pseudo-likelihood is usually preferred to full maximum likelihood since estimators of the parameters in the regression function obtained are more robust to misspecification of the variance function. Despite its popularity, however, existing theoretical results are difficult to apply and are of limited use in many applications. Using more recent results in estimating equations, we obtain an efficient algorithm for computing the pseudo-likelihood estimator with desirable convergence properties and also derive simple, explicit and easy to apply asymptotic results. These results are used to look in detail at variance minimization in off-line quality control, yielding techniques of inferences for the optimized design parameter. In application of some existing approaches to off-line quality control, such as the dual response methodology, rigorous statistical inference techniques are scarce and difficult to obtain. An example of off-line quality control is presented to discuss the practical aspects involved in the application of the results obtained and to address issues such as data transformation, model building and the optimization of design parameters. The analysis shows very encouraging results, and is seen to be able to unveil some important information not found in previous analyses.     

Restricted minimax robust designs for misspecified regression models

The authors propose and explore new regression designs. Within a particular parametric class, these designs are minimax robust against bias caused by model misspecification while attaining reasonable levels of efficiency as well. The introduction of this restricted class of designs is motivated by a desire to avoid the mathematical and numerical intractability found in the unrestricted minimax theory. Robustness is provided against a family of model departures sufficiently broad that the minimax design measures are necessarily absolutely continuous. Examples of implementation involve approximate polynomial and second order multiple regression.     

A likelihood ratio test for goodness‐of‐fit of recessive and dominant models for case–control studies

Testing goodness‐of‐fit of commonly used genetic models is of critical importance in many applications including association studies and testing for departure from Hardy–Weinberg equilibrium. Case–control design has become widely used in population genetics and genetic epidemiology, thus it is of interest to develop powerful goodness‐of‐fit tests for genetic models using case–control data. This paper develops a likelihood ratio test (LRT) for testing recessive and dominant models for case–control studies. The LRT statistic has a closed‐form formula with a simple $\chi^{2}(1)$ null asymptotic distribution, thus its implementation is easy even for genome‐wide association studies. Moreover, it has the same power and optimality as when the disease prevalence is known in the population. The Canadian Journal of Statistics 41: 341–352; 2013 © 2013 Statistical Society of Canada