Example of Block Designs for Plant and Tree Breeding Trials

Experimental designs which use extensive blocking and which are particularly useful in plant and tree breeding trials are discussed. They can be constructed either to accommodate field restrictions or take advantage of favourable plot layouts. Computer software is available to generate these design types for use in practice. Examples cover latinized row-column designs, t -latinized and partially-latinized designs and designs with unequal block sizes.     

A Greedy Randomized Adaptive Search Procedure for the Feedback Vertex Set Problem

A Greedy Randomized Adaptive Search Procedure (GRASP) is a randomized heuristic that has produced high quality solutions for a wide range of combinatorial optimization problems. The NP-complete Feedback Vertex Set (FVS) Problem is to find the minimum number of vertices that need to be removed from a directed graph so that the resulting graph has no directed cycle. The FVS problem has found applications in many fields, including VLSI design, program verification, and statistical inference. In this paper, we develop a GRASP for the FVS problem. We describe GRASP construction mechanisms and local search, as well as some efficient problem reduction techniques. We report computational experience on a set of test problems using three variants of GRASP.     

Two-stage k-sample designs for the ordered alternative problem

In preclinical studies and clinical dose-ranging trials, the Jonckheere-Terpstra test is widely used in the assessment of dose-response relationships. Hewett and Spurrier (1979) presented a two-stage analog of the test in the context of large sample sizes. In this paper, we propose an exact test based on Simon's minimax and optimal design criteria originally used in one-arm phase II designs based on binary endpoints. The convergence rate of the joint distribution of the first and second stage test statistics to the limiting distribution is studied, and design parameters are provided for a variety of assumed alternatives. The behavior of the test is also examined in the presence of ties, and the proposed designs are illustrated through application in the planning of a hypercholesterolemia clinical trial. The minimax and optimal two-stage procedures are shown to be preferable as compared with the one-stage procedure because of the associated reduction in expected sample size for given error constraints.     

Curtailed two-stage designs with two dependent binary endpoints

When phase I clinical trials were found to be unable to precisely estimate the frequency of toxicity, Brayan and Day proposed incorporating toxicity considerations into two-stage designs in phase II clinical trials. Conaway and Petroni further pointed out that it is important to evaluate the clinical activity and safety simultaneously in studying cancer treatments with more toxic chemotherapies in a phase II clinical trial. Therefore, they developed multi-stage designs with two dependent binary endpoints. However, the usual sample sizes in phase II trials make these designs difficult to control the type I error rate at a desired level over the entire null region and still have sufficient power against reasonable alternatives. Therefore, the curtailed sampling procedure summarized by Phatak and Bhatt will be applied to the two-stage designs with two dependent binary endpoints in this paper to reduce sample sizes and speed up the development process for drugs.     

Constructing optimal projection designs

ABSTRACT

The early stages of many real-life experiments involve a large number of factors among which only a few factors are active. Unfortunately, the optimal full-dimensional designs of those early stages may have bad low-dimensional projections and the experimenters do not know which factors turn out to be important before conducting the experiment. Therefore, designs with good projections are desirable for factor screening. In this regard, significant questions are arising such as whether the optimal full-dimensional designs have good projections onto low dimensions? How experimenters can measure the goodness of a full-dimensional design by focusing on all of its projections?, and are there linkages between the optimality of a full-dimensional design and the optimality of its projections? Through theoretical justifications, this paper tries to provide answers to these interesting questions by investigating the construction of optimal (average) projection designs for screening either nominal or quantitative factors. The main results show that: based on the aberration and orthogonality criteria the full-dimensional design is optimal if and only if it is optimal projection design; the full-dimensional design is optimal via the aberration and orthogonality if and only if it is uniform projection design; there is no guarantee that a uniform full-dimensional design is optimal projection design via any criterion; the projection design is optimal via the aberration, orthogonality and uniformity criteria if it is optimal via any criterion of them; and the saturated orthogonal designs have the same average projection performance.     

The performance of subset response surface designs for estimating third order terms

Response surface designs are widely used in industries like chemicals, foods, pharmaceuticals, bioprocessing, agrochemicals, biology, biomedicine, agriculture and medicine. One of the major objectives of these designs is to study the functional relationship between one or more responses and a number of quantitative input factors. However, biological materials have more run to run variation than in many other experiments, leading to the conclusion that smaller response surface designs are inappropriate. Thus designs to be used in these research areas should have greater replication. Gilmour (2006) introduced a wide class of designs called “subset designs” which are useful in situations in which run to run variation is high. These designs allow the experimenter to fit the second order response surface model. However, there are situations in which the second order model representation proves to be inadequate and unrealistic due to the presence of lack of fit caused by third or higher order terms in the true response surface model. In such situations it becomes necessary for the experimenter to estimate these higher order terms. In this study, the properties of subset designs, in the context of the third order response surface model, are explored.     

Use of Two Decks of Cards in Randomized Response Techniques for Complex Survey Designs

The randomized response (RR) technique with two decks of cards proposed by Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) can always be made more efficient than the RR techniques proposed by Warner (1965 Warner , S. L. ( 1965 ). Randomize response: A survey technique for eliminating evasive answer bias . J. Amer. Statist. Assoc. 60 : 63 – 69 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Mangat and Singh (1990 Mangat , N. S. , Singh , R. ( 1990 ). An alternative randomized response procedure . Biometrika 77 : 349 – 442 .[Crossref], [Web of Science ®] , [Google Scholar]), and Mangat (1994 Mangat , N. S. ( 1994 ). An improved randomized response strategy . J. Roy. Statist. Soc. B 56 : 93 – 95 . [Google Scholar]) by adjusting the proportion of cards in the decks. The proposed method of Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) is limited to simple random sampling with replacement (SRSWR) sampling only. In this article, generalization of Odumade and Singh strategy is provided for complex survey designs and a wider class of estimators. The results of Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) can be derived from the proposed method as a special case.     

A heuristic approach to long-haul freight transportation with multiple objective functions

This paper studies a long-haul freight transportation problem stimulated by a real-life application, whose underlying vehicle routing problem is a multi-objective one, where travel time and route cost are to be minimized together with the maximization of a transportation mean sharing index, related to the capability of the transportation system of generating economy scale solutions. In terms of constraints, besides vehicle capacity and time windows, transportation jobs have to obey additional constraints related to mandatory nodes (e.g., logistic platform nearest to the origin or the destination) and forbidden nodes (e.g., logistic platforms not compatible with the operations required). Based on the network definition, routes can be multimodal. To solve this problem, we propose a heuristic algorithm that can be applied in the tactical and the operational planning phase, and present the results of an extensive experimentation.     

Bayesian D-optimal supersaturated designs

We introduce a new class of supersaturated designs using Bayesian D-optimality. The designs generated using this approach can have arbitrary sample sizes, can have any number of blocks of any size, and can incorporate categorical factors with more than two levels. In side by side diagnostic comparisons based on the E(s²)$E(s^2)$ criterion for two-level experiments having even sample size, our designs either match or out-perform the best designs published to date. The generality of the method is illustrated with quality improvement experiment with 15 runs and 20 factors in 3 blocks.     

New 3-level response surface designs constructed from incomplete block designs

Box and Behnken [1958. Some new three level second-order designs for surface fitting. Statistical Technical Research Group Technical Report No. 26. Princeton University, Princeton, NJ; 1960. Some new three level designs for the study of quantitative variables. Technometrics 2, 455–475.] introduced a class of 3-level second-order designs for fitting the second-order response surface model. These 17 Box–Behnken designs (BB designs) are available for 3–12 and 16 factors. Although BB designs were developed nearly 50 years ago, they and the central-composite designs of Box and Wilson [1951. On the experimental attainment of optimum conditions. J. Royal Statist. Soc., Ser. B 13, 1–45.] are still the most often recommended response surface designs. Of the 17 aforementioned BB designs, 10 were constructed from balanced incomplete block designs (BIBDs) and seven were constructed from partially BIBDs (PBIBDs). In this paper we show that these seven BB designs constructed from PBIBDs can be improved in terms of rotatability as well as average prediction variance, D$D$- and G$G$-efficiency. In addition, we also report new orthogonally blocked solutions for 5, 8, 9, 11 and 13 factors. Note that an 11-factor BB design is available but cannot be orthogonally blocked. All new designs can be found at http://www.math.montana.edu/∼$\sim$jobo/bbd/.