Hit and run ARMS: adaptive rejection Metropolis sampling with hit and run random direction

An algorithm for sampling from non-log-concave multivariate distributions is proposed, which improves the adaptive rejection Metropolis sampling (ARMS) algorithm by incorporating the hit and run sampling. It is not rare that the ARMS is trapped away from some subspace with significant probability in the support of the multivariate distribution. While the ARMS updates samples only in the directions that are parallel to dimensions, our proposed method, the hit and run ARMS (HARARMS), updates samples in arbitrary directions determined by the hit and run algorithm, which makes it almost not possible to be trapped in any isolated subspaces. The HARARMS performs the same as ARMS in a single dimension while more reliable in multidimensional spaces. Its performance is illustrated by a Bayesian free-knot spline regression example. We showed that it overcomes the well-known ‘lethargy’ property and decisively find the global optimal number and locations of the knots of the spline function.     

A simulation study of deterministic ridge estimators

Some deterministic ridge rules are proposed and their finite sample properties are studied. Further, a simulation study is also conducted. Based on the simulation results, the proposed ridge estimators can improve the mean squared error over the least squares estimator, provided that the condition number of correlation matrices in the regression model is large, say at least 1,000.     

Reducing errors-in-variables bias in linear regression using compact genetic algorithms

A new technique is devised to mitigate the errors-in-variables bias in linear regression. The procedure mimics a 2-stage least squares procedure where an auxiliary regression which generates a better behaved predictor variable is derived. The generated variable is then used as a substitute for the error-prone variable in the first-stage model. The performance of the algorithm is tested by simulation and regression analyses. Simulations suggest the algorithm efficiently captures the additive error term used to contaminate the artificial variables. Regressions provide further credit to the simulations as they clearly show that the compact genetic algorithm-based estimate of the true but unobserved regressor yields considerably better results. These conclusions are robust across different sample sizes and different variance structures imposed on both the measurement error and regression disturbances.     

Spatially-adaptive Penalties for Spline Fitting

The paper studies spline fitting with a roughness penalty that adapts to spatial heterogeneity in the regression function. The estimates are p th degree piecewise polynomials with p − 1 continuous derivatives. A large and fixed number of knots is used and smoothing is achieved by putting a quadratic penalty on the jumps of the p th derivative at the knots. To be spatially adaptive, the logarithm of the penalty is itself a linear spline but with relatively few knots and with values at the knots chosen to minimize the generalized cross validation (GCV) criterion. This locally-adaptive spline estimator is compared with other spline estimators in the literature such as cubic smoothing splines and knot-selection techniques for least squares regression. Our estimator can be interpreted as an empirical Bayes estimate for a prior allowing spatial heterogeneity. In cases of spatially heterogeneous regression functions, empirical Bayes confidence intervals using this prior achieve better pointwise coverage probabilities than confidence intervals based on a global-penalty parameter. The method is developed first for univariate models and then extended to additive models.     

Semiparametric statistical inferences for longitudinal data with nonparametric covariance modelling

In this paper, semiparametric modelling for longitudinal data with an unstructured error process is considered. We propose a partially linear additive regression model for longitudinal data in which within-subject variances and covariances of the error process are described by unknown univariate and bivariate functions, respectively. We provide an estimating approach in which polynomial splines are used to approximate the additive nonparametric components and the within-subject variance and covariance functions are estimated nonparametrically. Both the asymptotic normality of the resulting parametric component estimators and optimal convergence rate of the resulting nonparametric component estimators are established. In addition, we develop a variable selection procedure to identify significant parametric and nonparametric components simultaneously. We show that the proposed SCAD penalty-based estimators of non-zero components have an oracle property. Some simulation studies are conducted to examine the finite-sample performance of the proposed estimation and variable selection procedures. A real data set is also analysed to demonstrate the usefulness of the proposed method.     

Comparison between Bayesian approach and frequentist methods for estimating relative risk in randomized controlled trials: a simulation study

Relative risks (RRs) are often considered as preferred measures of association in randomized controlled trials especially when the binary outcome of interest is common. To directly estimate RRs, log-binomial regression has been recommended. Although log-binomial regression is a special case of generalized linear models, it does not respect the natural parameter constraints, and maximum likelihood estimation is often subject to numerical instability that leads to convergence problems. Alternative methods for solving log-binomial regression convergence problems have been proposed. A Bayesian approach also was introduced, but the comparison between this method and frequentist methods has not been fully explored. We compared five frequentist and one Bayesian methods for estimating RRs under a variety of scenario. Based on our simulation study, there is not a method that can perform well based on different statistical properties, but COPY 1000 and modified log-Poisson regression can be considered in practice.     

On ridge parameter estimators under stochastic subspace hypothesis

This paper considers several estimators for estimating the restricted ridge parameter estimators. A simulation study has been conducted to compare the performance of these estimators. Based on the simulation study we found that, increasing the correlation between the independent variables has positive effect on the mean square error (MSE). However, increasing the value of ρ has negative effect on MSE. When the sample size increases, the MSE decreases even when the correlation between the independent variables is large. Two real life examples have been considered to illustrate the performance of the estimators.     

Fast Bayesian variable screenings for binary response regressions with small sample size

Screening procedures play an important role in data analysis, especially in high-throughput biological studies where the datasets consist of more covariates than independent subjects. In this article, a Bayesian screening procedure is introduced for the binary response models with logit and probit links. In contrast to many screening rules based on marginal information involving one or a few covariates, the proposed Bayesian procedure simultaneously models all covariates and uses closed-form screening statistics. Specifically, we use the posterior means of the regression coefficients as screening statistics; by imposing a generalized g-prior on the regression coefficients, we derive the analytical form of their posterior means and compute the screening statistics without Markov chain Monte Carlo implementation. We evaluate the utility of the proposed Bayesian screening method using simulations and real data analysis. When the sample size is small, the simulation results suggest improved performance with comparable computational cost.     

Robust multivariate mixture regression models with incomplete data

Multivariate mixture regression models can be used to investigate the relationships between two or more response variables and a set of predictor variables by taking into consideration unobserved population heterogeneity. It is common to take multivariate normal distributions as mixing components, but this mixing model is sensitive to heavy-tailed errors and outliers. Although normal mixture models can approximate any distribution in principle, the number of components needed to account for heavy-tailed distributions can be very large. Mixture regression models based on the multivariate t distributions can be considered as a robust alternative approach. Missing data are inevitable in many situations and parameter estimates could be biased if the missing values are not handled properly. In this paper, we propose a multivariate t mixture regression model with missing information to model heterogeneity in regression function in the presence of outliers and missing values. Along with the robust parameter estimation, our proposed method can be used for (i) visualization of the partial correlation between response variables across latent classes and heterogeneous regressions, and (ii) outlier detection and robust clustering even under the presence of missing values. We also propose a multivariate t mixture regression model using MM-estimation with missing information that is robust to high-leverage outliers. The proposed methodologies are illustrated through simulation studies and real data analysis.     

The Topp–Leone odd log-logistic family of distributions

We introduce a new class of continuous distributions named the Topp–Leone odd log-logistic family, which extends the one-parameter distribution pioneered by Topp and Leone [A family of J-shaped frequency functions. J Amer Statist Assoc. 1955;50:209–219]. We study some of its mathematical properties and describe two special cases. Further, we propose a regression model based on the new Topp–Leone odd log-logistic Weibull distribution. The usefulness and flexibility of the proposed family are illustrated by means of three real data sets.