Nonparametric Shrinkage Estimation for Aalen's Additive Hazards Model

Aalen's nonparametric additive model in which the regression coefficients are assumed to be unspecified functions of time is a flexible alternative to Cox's proportional hazards model when the proportionality assumption is in doubt. In this paper, we incorporate a general linear hypothesis into the estimation of the time‐varying regression coefficients. We combine unrestricted least squares estimators and estimators that are restricted by the linear hypothesis and produce James‐Stein‐type shrinkage estimators of the regression coefficients. We develop the asymptotic joint distribution of such restricted and unrestricted estimators and use this to study the relative performance of the proposed estimators via their integrated asymptotic distributional risks. We conduct Monte Carlo simulations to examine the relative performance of the estimators in terms of their integrated mean square errors. We also compare the performance of the proposed estimators with a recently devised LASSO estimator as well as with ridge‐type estimators both via simulations and data on the survival of primary billiary cirhosis patients.     

James - stein regression estimation in a prediction context

Two types of shrunken estimators of regression coefficients are studied in the context of stochastic predictor variables. Emphasis is placed on the choice of the shrinkage parameters, using a ‘deleted-observation’ concept which is motivated by predictive ability.     

On the construction of optimal experimental designs: a penalty approach

Tn optimal experimental design theory there are well-known situations, in which additional constraints are implied to the design set. These constraints destroy in general the simplex structure of the set of feasible points of the design set. Thus the available iteration procedures for the unrestricted case are no longer applicable.

In this paper a penalty approach is suggested which transforms the restricted problem to the unrestricted case and allows the application of well-known algorithms such as the Fedorov-Wynn-type or the projected gradient procedure.     

Asymptotic expansions for sequential confidence levels in inverse linear regression

Non-linear renewal theory is used to derive second order asymptotic expansions for the coverage probability of a fixed-width sequential confidence interval for an unknown parameter xin the inverse linear regression model. These expansions are obtained for a two-stage sequential procedure, proposed by Perng and Tong (1974) for the construction of a confidence interval for x.     

The exact properties of the lawless and wang operational ridge regression estimator in a misspecified regression equation

The exact properties of the Lawless and Wang Operational Ridge Regression estimator are derived in the context of a misspecified regression equation.     

Analysis of Deviance for Hypothesis Testing in Generalized Partially Linear Models

In this study, we develop nonparametric analysis of deviance tools for generalized partially linear models based on local polynomial fitting. Assuming a canonical link, we propose expressions for both local and global analysis of deviance, which admit an additivity property that reduces to analysis of variance decompositions in the Gaussian case. Chi-square tests based on integrated likelihood functions are proposed to formally test whether the nonparametric term is significant. Simulation results are shown to illustrate the proposed chi-square tests and to compare them with an existing procedure based on penalized splines. The methodology is applied to German Bundesbank Federal Reserve data.     

Identifying radon-prone building typologies by marginal modelling

Radon is a naturally occurring decay product of uranium known to be the main contributor to natural background radiation exposure. It has been established that the health risk related to radon exposure is lung cancer. In fact, radon is considered to be a major leading cause of lung cancer, second only to smoking. In this paper, we identified building typologies that affect the probability of detecting indoor radon concentration above reference values, using the data collected within two monitoring campaigns recently conducted in Northern Italy. This information is fundamental both in prevention, i.e. when the construction of a new building is planned and in mitigation, i.e. when a high concentration detected inside buildings has to be reduced. A spatial regression approach for binary data was adopted for this goal where some relevant covariates on the soil were retrieved by linking external spatial databases.     

Ridge Regression: Degrees of Freedom in the Analysis of Variance

It appears to be common practice with ridge regression to obtain a decomposition of the total sum of squares, and assign degrees of freedom, according to established least squares theory. This discussion notes the obvious fallacies of such an approach, and introduces a decomposition based on orthogonality, and degrees of freedom based on expected mean squares, for non-stochastic k.     

Alternative tests for heteroscedasticity of disturbances:a comparative study

This paper presents three small sample tests for testing the heteroscedasticity among regression disturbances. The power of these tests are compared with two of the leading tests for this hypothesis, one by Goldfeld and Quandt [5] and the other by Theil [17]. We also provide a heuristic method of selecting the number of middle observations to be deleted for the Goldfeld-Quandt type of tests.     

Efficacy of Statistical Outlier Analysis for Monitoring Quality of Care

Researchers have proposed that hospitals with excessive statistically unexplained mortality rates are more likely to have quality-of-care problems. The U.S. Health Care Financing Administration currently uses this statistical “outlier” approach to screen for poor quality in hospitals. Little is known, however, about the validity of this technique, since direct measures of quality are difficult to obtain. We use Monte Carlo methods to evaluate the performance of the outlier technique as parameters of the true mortality process are varied. Results indicate that the screening ability of the technique may be very sensitive to how widespread quality-related mortality is among hospitals but insensitive to other factors generally thought to be important.