Statistical Inference for Stochastic Dominance and for the Measurement of Poverty and Inequality

We derive the asymptotic sampling distribution of various estimators frequently used to order distributions in terms of poverty, welfare, and inequality. This includes estimators of most of the poverty indices currently in use, as well as estimators of the curves used to infer stochastic dominance of any order. These curves can be used to determine whether poverty, inequality, or social welfare is greater in one distribution than in another for general classes of indices and for ranges of possible poverty lines. We also derive the sampling distribution of the maximal poverty lines up to which we may confidently assert that poverty is greater in one distribution than in another. The sampling distribution of convenient dual estimators for the measurement of poverty is also established. The statistical results are established for deterministic or stochastic poverty lines as well as for paired or independent samples of incomes. Our results are briefly illustrated using data for four countries drawn from the Luxembourg Income Study data bases.     

Child protection: a new approach in South Australia

This paper argues the case for an integrated approach to child protection services, embracing children's safety, risk and needs and incorporating formal assessment instruments. It then provides a brief overview of the new child protection system in South Australia. The steady rise in child abuse/neglect reports raises questions about how best to provide child protection services. Analysis of South Australian data suggests that much of the rise can be attributed to an increase in reports of neglect and emotional abuse and an increase in re‐notifications. This in turn raises questions about the traditional investigative approach. In 1995 Messages from Research advocated that agencies re‐focus on children's needs and concentrate less on investigations into safety and risk. The critical question is how to distinguish families requiring investigation from those needing support. The latest research suggests that such decision‐making in child protection is generally inconsistent and unreliable. This paper argues that statutory agencies should use formal assessment tools to determine the level and nature of their interventions. These arguments have been critical in the development of the new child protection model in SA, which relies on a centralized intake, differential response to reports and the structured decision‐making system. Initial evaluation of the new model indicates improvements in consistency of initial screening and responses to children in danger. Copyright © 1999 John Wiley & Sons, Ltd.     

ESTIMATION OF MULTIVARIATE SHANNON ENTROPY USING MOMENTS

Three new entropy estimators of multivariate distributions are introduced. The two cases considered here concern when the distribution is supported by a unit sphere and by a unit cube. In the former case, the consistency and the upper bound of the absolute error for the proposed entropy estimator are established. In the latter one, under the assumption that only the moments of the underlying distribution are available, a non‐traditional estimator of the entropy is suggested. We also study the practical performances of the constructed estimators through simulation studies and compare the estimators based on the moment‐recovered approaches with their counterparts derived by using the histogram and k th nearest neighbour constructions. In addition, one worked example is briefly discussed.     

Two‐sample empirical likelihood ratio tests for medians in application to biomarker evaluations

The median is a commonly used parameter to characterize biomarker data. In particular, with two vastly different underlying distributions, comparing medians provides different information than comparing means; however, very few tests for medians are available. We propose a series of two‐sample median‐specific tests using empirical likelihood methodology and investigate their properties. We present the technical details of incorporating the relevant constraints into the empirical likelihood function for in‐depth median testing. An extensive Monte Carlo study shows that the proposed tests have excellent operating characteristics even under unfavourable occasions such as non‐exchangeability under the null hypothesis. We apply the proposed methods to analyze biomarker data from Western blot analysis to compare normal cells with bronchial epithelial cells from a case–control study. The Canadian Journal of Statistics 39: 671–689; 2011. © 2011 Statistical Society of Canada     

A note on testing the regression functions via nonparametric smoothing

The authors present a consistent lack‐of‐fit test in nonlinear regression models. The proposed procedure possesses some nice properties of Zheng's test such as the consistency, the ability to detect any local alternatives approaching the null at rates slower than the parametric rate. What's more, for a predetermined kernel function, the proposed test is more powerful than Zheng's test and the validity of these findings is confirmed by the simulation studies and a real data example. In addition, the authors find out a close connection between the choices of normal kernel functions and the bandwidths. The Canadian Journal of Statistics 39: 108–125; 2011 © 2011 Statistical Society of Canada     

A note on Läuter-type robust design for polynomial regression models

In this paper, we consider the problem of model robust design for simultaneous parameter estimation among a class of polynomial regression models with degree up to k. A generalized D-optimality criterion, the Ψ_α‐optimality criterion, first introduced by Läuter (1974) is considered for this problem. By applying the theory of canonical moments and the technique of maximin principle, we derive a model robust optimal design in the sense of having highest minimum Ψ_α‐efficiency. Numerical comparison indicates that the proposed design has remarkable performance for parameter estimation in all of the considered rival models.     

A ratio-to-control Williams-type test for trend

Under certain conditions, many multiple contrast tests based on the difference of treatment means can also be conveniently expressed in terms of ratios. In this paper, a Williams test for trend is defined as ratios-to-control for ease of interpretation and to obtain directly comparable confidence intervals. Simultaneous confidence intervals for percentages are particularly helpful for interpretations in the case of multiple endpoints. Methods for constructing simultaneous confidence intervals are discussed under both homogeneous and heterogeneous error variances. This approach is available in the R extension package mratios. The proposed method is used to test for trend in an immunotoxicity study with several endpoints as an example.     

A course for clinical trial personnel in clinical study designs, randomization, allocation schedules, and interactive response systems

This continuing education course for professionals involved in all areas of clinical trials integrates concepts related to the role of randomization in the scientific process. The course includes two interactive lecture and discussion sections and a workshop practicum. The first interactive lecture introduces basic clinical trial issues and statistical principles such as bias, blinding, randomization, control groups, and the importance of formulating clear and discriminating clinical and statistical hypotheses. It then focuses on the most commonly used clinical study designs and the corresponding patient randomization schemes. The second interactive lecture focuses on the implementation of randomization of patients and drug supply through allocation and component ID schedules. The workshop practicum, conducted in small groups, enables students to apply the lecture concepts to real clinical studies. Flexibility was built into the workshop practicum materials to allow the course content to be customized to specific audiences, and the interactive lecture sessions can be stretched to cover more advanced topics according to class interest and time availability.     

The potential for bias in reporting of industry-sponsored clinical trials

Concerns about potentially misleading reporting of pharmaceutical industry research have surfaced many times. The potential for duality (and thereby conflict) of interest is only too clear when you consider the sums of money required for the discovery, development and commercialization of new medicines. As the ability of major, mid-size and small pharmaceutical companies to innovate has waned, as evidenced by the seemingly relentless decline in the numbers of new medicines approved by Food and Drug Administration and European Medicines Agency year-on-year, not only has the cost per new approved medicine risen: so too has the public and media concern about the extent to which the pharmaceutical industry is open and honest about the efficacy, safety and quality of the drugs we manufacture and sell. In 2005 an Editorial in Journal of the American Medical Association made clear that, so great was their concern about misleading reporting of industry-sponsored studies, henceforth no article would be published that was not also guaranteed by independent statistical analysis. We examine the precursors to this Editorial, as well as its immediate and lasting effects for statisticians, for the manner in which statistical analysis is carried out, and for the industry more generally.