An individual measure of relative survival

Summary.  Relative survival techniques are used to compare survival experience in a study cohort with that expected if background population rates apply. The techniques are especially useful when cause-specific death information is not accurate or not available as they provide a measure of excess mortality in a group of patients with a certain disease. Whereas these methods are based on group comparisons, we present here a transformation approach which instead gives for each individual an outcome measure relative to the appropriate background population. The new outcome measure is easily interpreted and can be analysed by using standard survival analysis techniques. It provides additional information on relative survival and gives new options in regression analysis. For example, one can estimate the proportion of patients who survived longer than a given percentile of the respective general population or compare survival experience of individuals while accounting for the population differences. The regression models for the new outcome measure are different from existing models, thus providing new possibilities in analysing relative survival data. One distinctive feature of our approach is that we adjust for expected survival before modelling. The paper is motivated by a study into the survival of patients after acute myocardial infarction.     

"生态旅游"概念探微

选取国外 44个生态旅游定义作为研究对象 ,通过确认关键词、对关键词进行聚类分析 ,将定义内容归纳为 6大类 11组分 ,进而构建生态旅游概念模型。在检验模型理论上的可靠性和实践上的适应性后 ,依据模型提出自己的生态旅游定义     

On Block Updating in Markov Random Field Models for Disease Mapping

Gaussian Markov random field (GMRF) models are commonly used to model spatial correlation in disease mapping applications. For Bayesian inference by MCMC, so far mainly single-site updating algorithms have been considered. However, convergence and mixing properties of such algorithms can be extremely poor due to strong dependencies of parameters in the posterior distribution. In this paper, we propose various block sampling algorithms in order to improve the MCMC performance. The methodology is rather general, allows for non-standard full conditionals, and can be applied in a modular fashion in a large number of different scenarios. For illustration we consider three different applications: two formulations for spatial modelling of a single disease (with and without additional unstructured parameters respectively), and one formulation for the joint analysis of two diseases. The results indicate that the largest benefits are obtained if parameters and the corresponding hyperparameter are updated jointly in one large block. Implementation of such block algorithms is relatively easy using methods for fast sampling of Gaussian Markov random fields ( Rue, 2001 ). By comparison, Monte Carlo estimates based on single-site updating can be rather misleading, even for very long runs. Our results may have wider relevance for efficient MCMC simulation in hierarchical models with Markov random field components.     

广义孙子定理

给出了一次同余式组的解的计算公式.     

佛山市旅游市场结构的初步分析

佛山市旅游发展与其经济发展水平相比相对滞后，旅游市场发育不够完善，在旅游市场结构上表现为：区内客源市场已趋完善，省内近程客源市场正在形成，省内远程客源市场已现端倪，而省外客源市场尚未具备。所以，佛山旅游业的发展要求根据佛山旅游市场结构的特点，有层次性、倾向性和综合性地加强旅游市场的开发。     

Nonparametric smoothing in the analysis of air pollution and respiratory illness

While most of epidemiology is observational, rather than experimental, the culture of epidemiology is still derived from agricultural experiments, rather than other observational fields, such as astronomy or economics. The mismatch is made greater as focus has turned to continue risk factors, multifactorial outcomes, and outcomes with large variation unexplainable by available risk factors. The analysis of such data is often viewed as hypothesis testing with statistical control replacing randomization. However, such approaches often test restricted forms of the hypothesis being investigated, such as the hypothesis of a linear association, when there is no prior empirical or theoretical reason to believe that if an association exists, it is linear. In combination with the large nonstochastic sources of error in such observational studies, this suggests the more flexible alternative of exploring the association. Conclusions on the possible causal nature of any discovered association will rest on the coherence and consistency of multiple studies. Nonparametric smoothing in general, and generalized additive models in particular, represent an attractive approach to such problems. This is illustrated using data examining the relationship between particulate air pollution and daily mortality in Birmingham, Alabama; between particulate air pollution, ozone, and SO₂ and daily hospital admissions for respiratory illness in Philadelphia; and between ozone and particulate air pollution and coughing episodes in children in six eastern U.S. cities. The results indicate that airborne particles and ozone are associated with adverse health outcomes at very low concentrations, and that there are likely no thresholds for these relationships.     

Collapsing the Boundaries? Fatherhood,Organization and Home‐Working

In the modern western world, the discursive construction of fatherhood and everyday fathering practices has been underpinned by the spatial separation of work from home, of public from private. However, increasing numbers of employees are now working from home and a disproportionate number of these are men with young children. This article draws on new empirical research to examine the implications for fathers and for organizations as home‐working disrupts earlier spatial configurations of fatherhood and fathering practices. The article concludes that as the spatial boundaries between home and work collapse, new accommodations between fatherhood/fathering and organization are emerging. However, these are underpinned by a traditional gender division of labour in the household. More broadly, these findings confirm the inadequacy of static distinctions between public and private, showing that while such distinctions are still used to mark space and time, this is relational, contingent and unstable.     

房地产企业留住人才的博弈分析

本文通过建立博弈矩阵模型,并利用线性规划理论进行分析,指出房地产企业在提高工资待遇吸引人才的同时,建立有效的动态激励机制才是留住人才的关键.     

Physiologically Based Liver Modeling and Risk Assessment

Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments.     

对偶线性规划问题性质探析

探讨对偶线性规划的原始问题与对偶问题的属性，阐述两者的区别和内在联系，用较简便的方法论证其重要性质，揭示可行解与目标函数、可行解与最优解的关系，指出线性规划问题最优解从约束条件较少的对偶问题寻求为另一较简便之方法。