Estimation of a Change Point in a Hazard Function Based on Censored Data

The hazard function plays an important role in reliability or survival studies since it describes the instantaneous risk of failure of items at a time point, given that they have not failed before. In some real life applications, abrupt changes in the hazard function are observed due to overhauls, major operations or specific maintenance activities. In such situations it is of interest to detect the location where such a change occurs and estimate the size of the change. In this paper we consider the problem of estimating a single change point in a piecewise constant hazard function when the observed variables are subject to random censoring. We suggest an estimation procedure that is based on certain structural properties and on least squares ideas. A simulation study is carried out to compare the performance of this estimator with two estimators available in the literature: an estimator based on a functional of the Nelson-Aalen estimator and a maximum likelihood estimator. The proposed least squares estimator tums out to be less biased than the other two estimators, but has a larger variance. We illustrate the estimation method on some real data sets.     

On shrinkage least squares estimation in a parallelism problem

In a multi-sample simple regression model, generally, homogeneity of the regression slopes leads to improved estimation of the intercepts. Analogous to the preliminary test estimators, (smooth) shrinkage least squares estimators of Intercepts based on the James-Stein rule on regression slopes are considered. Relative pictures on the (asymptotic) risk of the classical, preliminary test and the shrinkage least squares estimators are also presented. None of the preliminary test and shrinkage least squares estimators may dominate over the other, though each of them fares well relative to the other estimators.     

Superiority comparisons between mixed regression estimators

This paper gives necessary and sufficient conditions for a mixed regression estimator to be superior to another mixed estimator. The comparisons are based on the mean square error matrices of the estimators. Both estimators are allowed to be biased.     

Multiple Linear Regression Model Under Nonnormality

Abstract

We consider multiple linear regression models under nonnormality. We derive modified maximum likelihood estimators (MMLEs) of the parameters and show that they are efficient and robust. We show that the least squares esimators are considerably less efficient. We compare the efficiencies of the MMLEs and the M estimators for symmetric distributions and show that, for plausible alternatives to an assumed distribution, the former are more efficient. We provide real-life examples.     

Least significant spacing for ‘one versus the rest’ normal populations

Consider sample means from k(≥2) normal populations where the variances and sample sizes are equal. The problem is to find the ‘least significant difference’ or ‘spacing’ (LSS) between the two largest means, so that if an observed spacing is larger we have confidence 1 - α that the population with largest sample mean also has the largest population mean.

When the variance is known it is shown that the maximum LSS occurs when k = 2, provided a < .2723. In other words, for any value of k we may use the usual (one-tailed) least significant difference to demonstrate that one population has a population mean greater than (or equal to) the rest.

When the variance is estimated bounds are obtained for the confidence which indicate that this last result is approximately correct.     

On the analysis of multivariate repeated measures designs

The relationship between the mixed-model analysis and multivariate approach to a repeated measures design with multiple responses is presented. It is shown that by taking the trace of the appropriate submatrix of the hypothesis (error) sums of squares and crossproducts (SSCP) matrix obtained from the multivariate approach, one can get the hypothesis (error) SSCP matrix for the mixed-model analysis. Thus, when analyzing data from a multivariate repeated measures design, it is advantageous to use the multivariate approach because the result of the mixed-model analysis can also be obtained without additional computation.     

Two-Event Model for Carcinogenesis: Biological, Mathematical, and Statistical Considerations

A two-mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time-dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.     

基于非线性偏最小二乘的操作臂逆解算法

操作臂逆运动学问题是机器人控制中的一项重要内容。目前使用较多的神经网络法大多为多输入多输出或者 多输入单输出方式,需要大量运算。非线性偏最小二乘法( NLPLS)建立的模型分为内部和外部模型,样本数据经外部模 型处理后才用于训练若干个单输入单输出的神经网络。对PUMA560操作臂的仿真试验表明,在相同隐层神经元数的情 况下,该算法比普通神经网络法具有更好的预测精度。这也表明,NLPLS只需较少的隐层神经元数就可以达到普通方法 的精度,从而减少运算量。     

Nonparametric multiple expectile regression via ER-Boost

Expectile regression [Newey W, Powell J. Asymmetric least squares estimation and testing, Econometrica. 1987;55:819–847] is a nice tool for estimating the conditional expectiles of a response variable given a set of covariates. Expectile regression at 50% level is the classical conditional mean regression. In many real applications having multiple expectiles at different levels provides a more complete picture of the conditional distribution of the response variable. Multiple linear expectile regression model has been well studied [Newey W, Powell J. Asymmetric least squares estimation and testing, Econometrica. 1987;55:819–847; Efron B. Regression percentiles using asymmetric squared error loss, Stat Sin. 1991;1(93):125.], but it can be too restrictive for many real applications. In this paper, we derive a regression tree-based gradient boosting estimator for nonparametric multiple expectile regression. The new estimator, referred to as ER-Boost, is implemented in an R package erboost publicly available at http://cran.r-project.org/web/packages/erboost/index.html. We use two homoscedastic/heteroscedastic random-function-generator models in simulation to show the high predictive accuracy of ER-Boost. As an application, we apply ER-Boost to analyse North Carolina County crime data. From the nonparametric expectile regression analysis of this dataset, we draw several interesting conclusions that are consistent with the previous study using the economic model of crime. This real data example also provides a good demonstration of some nice features of ER-Boost, such as its ability to handle different types of covariates and its model interpretation tools.     

基于两阶段风险的定制类信息系统开发项目绩效模型构建与实证研究

开发阶段绩效风险和实施阶段绩效风险是信息系统开发项目中两个重要的中介变量,它们调节了项目内在不确定性和管理实践对项目绩效的影响.在项目不同阶段,绩效风险的主要影响因素是不同的.在开发阶段,主要影响因素是项目计划和控制、内部整合和用户参与;在实施阶段,主要影响因素是用户参与和高层支持.另外,用户参与直接地正向影响产品绩效,但对过程绩效没有直接影响.过程绩效对产品绩效也没有显著的正向影响.