Robustness to non-normality and autocorrelation of individuals control charts

This paper studies the effects of non-normality and autocorrelation on the performances of various individuals control charts for monitoring the process mean and/or variance. The traditional Shewhart X chart and moving range (MR) chart are investigated as well as several types of exponentially weighted moving average (EWMA) charts and combinations of control charts involving these EWMA charts. It is shown that the combination of the X and MR charts will not detect small and moderate parameter shifts as fast as combinations involving the EWMA charts, and that the performana of the X and MR charts is very sensitive to the normality assumption. It is also shown that certain combinations of EWMA charts can be designed to be robust to non-normality and very effective at detecting small and moderate shifts in the process mean and/or variance. Although autocorrelation can have a significant effect on the in-control performances of these combinations of EWMA charts, their relative out-of-control performances under independence are generally maintained for low to moderate levels of autocorrelation.     

Comparing diagnostic tests: test of hypothesis for likelihood ratios

Likelihood ratios (LRs) are used to characterize the efficiency of diagnostic tests. In this paper, we use the classical weighted least squares (CWLS) test procedure, which was originally used for testing the homogeneity of relative risks, for comparing the LRs of two or more binary diagnostic tests. We compare the performance of this method with the relative diagnostic likelihood ratio (rDLR) method and the diagnostic likelihood ratio regression (DLRReg) approach in terms of size and power, and we observe that the performances of CWLS and rDLR are the same when used to compare two diagnostic tests, while DLRReg method has higher type I error rates and powers. We also examine the performances of the CWLS and DLRReg methods for comparing three diagnostic tests in various sample size and prevalence combinations. On the basis of Monte Carlo simulations, we conclude that all of the tests are generally conservative and have low power, especially in settings of small sample size and low prevalence.     

On the reciprocity of connections in weighted and unweighted networks

Bivariate Bernoulli and bivariate geometric distributions are proposed to model reciprocity in weighted and unweighted networks. Sampling properties of commonly used reciprocity measures are studied, under both presence and absence of reciprocity. Extensions to situations where link parameters depend on outgoing and incoming nodes are investigated. Results are illustrated with a data set, on 50 anesthesia providers at a hospital, that describes the number of times an anesthesia provider starting an operation transfers his/her responsibilities to another anesthesia provider.     

Modeling censored data using modified lambda family

In the present article we propose the modified lambda family (MLF) which is the Freimer, Mudholkar, Kollia, and Lin (FMKL) parametrization of generalized lambda distribution (GLD) as a model for censored data. The expressions for probability weighted moments of MLF are derived and used to estimate the parameters of the distribution. We modified the estimation technique using probability weighted moments. It is shown that the distribution provides reasonable fit to a real censored data.     

Asymptotic hypothesis test to simultaneously compare the weighted kappa coefficients of multiple binary diagnostic tests in the presence of ignorable missing data

The weighted kappa coefficient of a binary diagnostic test is a measure of the beyond-chance agreement between the diagnostic test and the gold standard, and is a measure that allows us to assess and compare the performance of binary diagnostic tests. In the presence of partial disease verification, the comparison of the weighted kappa coefficients of two or more binary diagnostic tests cannot be carried out ignoring the individuals with an unknown disease status, since the estimators obtained would be affected by verification bias. In this article, we propose a global hypothesis test based on the chi-square distribution to simultaneously compare the weighted kappa coefficients when in the presence of partial disease verification the missing data mechanism is ignorable. Simulation experiments have been carried out to study the type I error and the power of the global hypothesis test. The results have been applied to the diagnosis of coronary disease.     

Phase-II monitoring and diagnosing of multivariate categorical processes using generalized linear test-based control charts

In this paper, two control charts based on the generalized linear test (GLT) and contingency table are proposed for Phase-II monitoring of multivariate categorical processes. The performances of the proposed methods are compared with the exponentially weighted moving average-generalized likelihood ratio test (EWMA-GLRT) control chart proposed in the literature. The results show the better performance of the proposed control charts under moderate and large shifts. Moreover, a new scheme is proposed to identify the parameter responsible for an out-of-control signal. The performance of the proposed diagnosing procedure is evaluated through some simulation experiments.     

The economic design of multivariate binomial EWMA VSSI control charts

Since multi-attribute control charts have received little attention compared with multivariate variable control charts, this research is concerned with developing a new methodology to employ the multivariate exponentially weighted moving average (MEWMA) charts for m-attribute binomial processes; the attributes being the number of nonconforming items. Moreover, since the variable sample size and sampling interval (VSSI) MEWMA charts detect small process mean shifts faster than the traditional MEWMA, an economic design of the VSSI MEWMA chart is proposed to obtain the optimum design parameters of the chart. The sample size, the sampling interval, and the warning/action limit coefficients are obtained using a genetic algorithm such that the expected total cost per hour is minimized. At the end, a sensitivity analysis has been carried out to investigate the effects of the cost and the model parameters on the solution of the economic design of the VSSI MEWMA chart.     

Group sequential monitoring based on the weighted log‐rank test statistic with the Fleming–Harrington class of weights in cancer vaccine studies

In recent years, immunological science has evolved, and cancer vaccines are now approved and available for treating existing cancers. Because cancer vaccines require time to elicit an immune response, a delayed treatment effect is expected and is actually observed in drug approval studies. Accordingly, we propose the evaluation of survival endpoints by weighted log‐rank tests with the Fleming–Harrington class of weights. We consider group sequential monitoring, which allows early efficacy stopping, and determine a semiparametric information fraction for the Fleming–Harrington family of weights, which is necessary for the error spending function. Moreover, we give a flexible survival model in cancer vaccine studies that considers not only the delayed treatment effect but also the long‐term survivors. In a Monte Carlo simulation study, we illustrate that when the primary analysis is a weighted log‐rank test emphasizing the late differences, the proposed information fraction can be a useful alternative to the surrogate information fraction, which is proportional to the number of events. Copyright © 2016 John Wiley & Sons, Ltd.     

Outlier detection and robust variable selection via the penalized weighted LAD-LASSO method

This paper studies the outlier detection and robust variable selection problem in the linear regression model. The penalized weighted least absolute deviation (PWLAD) regression estimation method and the adaptive least absolute shrinkage and selection operator (LASSO) are combined to simultaneously achieve outlier detection, and robust variable selection. An iterative algorithm is proposed to solve the proposed optimization problem. Monte Carlo studies are evaluated the finite-sample performance of the proposed methods. The results indicate that the finite sample performance of the proposed methods performs better than that of the existing methods when there are leverage points or outliers in the response variable or explanatory variables. Finally, we apply the proposed methodology to analyze two real datasets.     

Semiparametric regression of clustered current status data

This paper discusses regression analysis of clustered current status data under semiparametric additive hazards models. In particular, we consider the situation when cluster sizes can be informative about correlated failure times from the same cluster. To address the problem, we present estimating equation-based estimation procedures and establish asymptotic properties of the resulting estimates. Finite sample performance of the proposed method is assessed through an extensive simulation study, which indicates the procedure works well. The method is applied to a motivating data set from a lung tumorigenicity study.