A nonparametric approach to detecting the difference of survival medians

Some nonparametric methods have been proposed to compare survival medians. Most of them are based on the asymptotic null distribution to estimate the p-value. However, for small to moderate sample sizes, those tests may have inflated Type I error rate, which makes their application limited. In this article, we proposed a new nonparametric test that uses bootstrap to estimate the sample mean and variance of the median. Through comprehensive simulation, we show that the proposed approach can control Type I error rates well. A real data application is used to illustrate the use of the new test.     

A Bayesian semiparametric accelerated failure time model for arbitrarily censored data with covariates subject to measurement error

A flexible Bayesian semiparametric accelerated failure time (AFT) model is proposed for analyzing arbitrarily censored survival data with covariates subject to measurement error. Specifically, the baseline error distribution in the AFT model is nonparametrically modeled as a Dirichlet process mixture of normals. Classical measurement error models are imposed for covariates subject to measurement error. An efficient and easy-to-implement Gibbs sampler, based on the stick-breaking formulation of the Dirichlet process combined with the techniques of retrospective and slice sampling, is developed for the posterior calculation. An extensive simulation study is conducted to illustrate the advantages of our approach.     

Likelihood ratio test-based chart for monitoring the process variability

This article proposes a new chart with the generalized likelihood ratio (GLR) test statistics for monitoring the process variance of a normally distributed process. The new chart can be easily designed and constructed and the computation results show that it provides quite a satisfactory performance, including the detection of the decrease in the variance and the individual observation at the sampling point which are very important in many practical applications. Average run length (ARL) comparisons between other procedures and the new chart are presented. The optimal parameters that can be used as a design aid in selecting specific parameter values based on the ARL are described. The application of our proposed method is illustrated by a real data example from chemical process control.     

Inference based on progressive Type I interval censored data from log-normal distribution

This article considers inference for the log-normal distribution based on progressive Type I interval censored data by both frequentist and Bayesian methods. First, the maximum likelihood estimates (MLEs) of the unknown model parameters are computed by expectation-maximization (EM) algorithm. The asymptotic standard errors (ASEs) of the MLEs are obtained by applying the missing information principle. Next, the Bayes’ estimates of the model parameters are obtained by Gibbs sampling method under both symmetric and asymmetric loss functions. The Gibbs sampling scheme is facilitated by adopting a similar data augmentation scheme as in EM algorithm. The performance of the MLEs and various Bayesian point estimates is judged via a simulation study. A real dataset is analyzed for the purpose of illustration.     

Restricted ridge estimator in the logistic regression model

It is known that when the multicollinearity exists in the logistic regression model, variance of maximum likelihood estimator is unstable. As a remedy, Schaefer et al. presented a ridge estimator in the logistic regression model. Making use of the ridge estimator, when some linear restrictions are also present, we introduce a restricted ridge estimator in the logistic regression model. Statistical properties of this newly defined estimator will be studied and comparisons are done in the simulation study in the sense of mean squared error criterion. A real-data example and a simulation study are introduced to discuss the performance of this estimator.     

Adaptive procedure for generalized familywise error rate control

This article considers multiple hypotheses testing with the generalized familywise error rate k-FWER control, which is the probability of at least k false rejections. We first assume the p-values corresponding to the true null hypotheses are independent, and propose adaptive generalized Bonferroni procedure with k-FWER control based on the estimation of the number of true null hypotheses. Then, we assume the p-values are dependent, satisfying block dependence, and propose adaptive procedure with k-FWER control. Extensive simulations compare the performance of the adaptive procedures with different estimators.     

Assessing Type I error and power of multistate Markov models for panel data—A simulation study

Ordinal outcomes collected at multiple follow-up visits are common in clinical trials. Sometimes, one visit is chosen for the primary analysis and the scale is dichotomized amounting to loss of information. Multistate Markov models describe how a process moves between states over time. Here, simulation studies are performed to investigate the Type I error and power characteristics of multistate Markov models for panel data with limited non-adjacent state transitions. The results suggest that the multistate Markov models preserve the Type I error and adequate power is achieved with modest sample sizes for panel data with limited non-adjacent state transitions.