Evaluation of Inhaled Versus Deposited Dose Using the Exponential Dose‐Response Model for Inhalational Anthrax in Nonhuman Primate,Rabbit, and Guinea Pig

The application of the exponential model is extended by the inclusion of new nonhuman primate (NHP), rabbit, and guinea pig dose‐lethality data for inhalation anthrax. Because deposition is a critical step in the initiation of inhalation anthrax, inhaled doses may not provide the most accurate cross‐species comparison. For this reason, species‐specific deposition factors were derived to translate inhaled dose to deposited dose. Four NHP, three rabbit, and two guinea pig data sets were utilized. Results from species‐specific pooling analysis suggested all four NHP data sets could be pooled into a single NHP data set, which was also true for the rabbit and guinea pig data sets. The three species‐specific pooled data sets could not be combined into a single generic mammalian data set. For inhaled dose, NHPs were the most sensitive (relative lowest LD₅₀) species and rabbits the least. Improved inhaled LD₅₀s proposed for use in risk assessment are 50,600, 102,600, and 70,800 inhaled spores for NHP, rabbit, and guinea pig, respectively. Lung deposition factors were estimated for each species using published deposition data from Bacillus spore exposures, particle deposition studies, and computer modeling. Deposition was estimated at 22%, 9%, and 30% of the inhaled dose for NHP, rabbit, and guinea pig, respectively. When the inhaled dose was adjusted to reflect deposited dose, the rabbit animal model appears the most sensitive with the guinea pig the least sensitive species.     

Performance management practices in lean manufacturing organizations: a systematic review of research evidence

This paper provides the first systematic look into the existing research on performance management (PM) practices employed in lean manufacturing organisations (LMOs). It adopts a systematic review method to examine the evidence generated in the period 2004 – 2015 and uses a comprehensive PM framework to synthesise the findings. The results suggest that PM practices that have the most prominent role in LMOs are those that, firstly, are located closest to front-line actions and, secondly, explicitly address operational realities. This calls into question the primacy of accounting-driven controls in LMOs, suggesting that operational controls may be more effective than top-down accounting-based PM practices. The results also confirm the bias towards operational-level issues but suggest that LMOs may integrate the operational and the strategic levels by using PM practices that drive organisational learning through employee involvement and engagement.     

Non-asymptotic sequential confidence regions with fixed sizes for the multivariate nonlinear parameters of regression

In this paper we consider a sequential design for the estimation of nonlinear parameters of regression with guaranteed accuracy. Non-asymptotic confidence regions with fixed sizes for the least squares estimates are used. The obtained confidence region is valid for finite numbers of data points when the distributions of the observations are unknown.     

Confidence intervals for treatment effect from restricted maximum likelihood

An explicit form of confidence intervals for the treatment effect in random effects meta-analysis model obtained from Harville–Jeske–Kenward–Roger approach is given. These restricted likelihood based intervals are compared to alternative procedures commonly used in collaborative studies when the number of participants is small and study-specific variances are heterogeneous. Monte Carlo simulation experiments show that the former intervals have quite conservative coverage probabilities and favor the latter intervals.     

On the relative accuracy of certain bootstrap procedures

We show the second-order relative accuracy, on bounded sets, of the Studentized bootstrap, exponentially tilted bootstrap and nonparametric likelihood tilted bootstrap, for means and smooth functions of means. We also consider the relative errors for larger deviations. Our method exploits certain connections between Edgeworth and saddlepoint approximations to simplify the computations.     

Optimal discrimination designs for exponential regression models

We investigate optimal designs for discriminating between exponential regression models of different complexity, which are widely used in the biological sciences; see, e.g., Landaw [1995. Robust sampling designs for compartmental models under large prior eigenvalue uncertainties. Math. Comput. Biomed. Appl. 181–187] or Gibaldi and Perrier [1982. Pharmacokinetics. Marcel Dekker, New York]. We discuss different approaches for the construction of appropriate optimality criteria, and find sharper upper bounds on the number of support points of locally optimal discrimination designs than those given by Caratheodory's Theorem. These results greatly facilitate the numerical construction of optimal designs. Various examples of optimal designs are then presented and compared to different other designs. Moreover, to protect the experiment against misspecifications of the nonlinear model parameters, we adapt the design criteria such that the resulting designs are robust with respect to such misspecifications and, again, provide several examples, which demonstrate the advantages of our approach.     

Some aspects of probability forecasting

The problems of assessing, comparing and combining probability forecasts for a binary events sequence are considered. A Gaussian threshold model (analytically of closed form) is introduced which allows generation of different probability forecast sequences valid for the same events. Chi - squared type test statistics, and also a marginal-conditional method are proposed for the assessment problem, and an asymptotic normality result is given. A graphical method is developed for the comparison problem, based upon decomposing arbitrary proper scoring rules into certain elementary scoring functions. The special role of the logarithmic scoring rule is examined in the context of Neyman - Pearson theory.     

Linear statistics in change-point estimation and their asymptotic behaviour

ABSTRACT The limiting behaviour of Bayes procedures in the asymptotic setting of the change-point estimation problem is studied. It is shown that the distribution of the difference between the Bayes estimator and the parameter converges to the distribution of a fairly complicated random variable. A class of linear statistics is introduced, and the form of the Bayes estimator within this class is deduced. The asymptotic properties of this linear estimator are investigated in two different settings for the prior distribution.     

Recursive procedures for multiple decisions: finite time memory and stepwise maximum likelihood procedure

A version of the multiple decsion problem is studied in which the procedure is based only on the current observation and the previous decision. A necessary and sufficient condition for inconsistency of the stepwise maximum likelihood procedure is shown to be the boundedness of the likelihood ratios. In the case of consistency the (typically slow) rate of convergence to zero of the error probabilities is determined.