Androgen deficiency in the adult male

Introduction. The purpose of this study was to investigate the association between severity of lower urinary tract symptoms (LUTS), erectile dysfunction (ED) and metabolic syndrome.

Methods. Our study population included a consecutive series of 190 patients with LUTS (International Prostate Symptom Score-IPSS >7) with or without manifestations of the metabolic syndrome. The diagnoses of diabetes mellitus and hypertension were obtained from the patient's medical history. Data on blood pressure, waist measure, body height and weight were collected and body mass index were calculated. Patients were assessed based on the International Index of Erectile Function (IIEF) for ED and IPSS and IPSS-Quality of Life for LUTS. Blood samples were drawn from fasting patients to determine, fasting blood glucose (FBG), triglycerides, HDL-cholesterol and serum total testosterone levels.

Results. In severe LUTS patient group, IIEF erectile function domain scores were significantly lower than moderate LUTS patient group (p < 0.05). Multiple logistic regression analysis confirmed that presence of ED was the most predictor of severe LUTS. The prevalence of metabolic syndrome was higher in patients with severe LUTS (26%vs. 46%, p = 0.009). The severe form of the LUTS was significantly correlated with waist circumference >102 cm (p < 0.05), blood pressure ≥130/85 mmHg (p < 0.05) and FBG >110 mg/dl (p < 0.01).

Conclusion. Obesity, high plasma level of FBG and hypertension constitute risk factors for the development of severe LUTS. Metabolic syndrome may play a key role in the pathogenesis in both ED and LUTS. Presence of ED is the most predictor of severe LUTS.     

Methods for Detecting and Estimating Population Threshold Concentrations for Air Pollution–Related Mortality with Exposure Measurement Error

The association between daily fluctuations in ambient particulate matter and daily variations in nonaccidental mortality have been extensively investigated. Although it is now widely recognized that such an association exists, the form of the concentration–response model is still in question. Linear, no threshold and linear threshold models have been most commonly examined. In this paper we considered methods to detect and estimate threshold concentrations using time series data of daily mortality rates and air pollution concentrations. Because exposure is measured with error, we also considered the influence of measurement error in distinguishing between these two completing model specifications. The methods were illustrated on a 15-year daily time series of nonaccidental mortality and particulate air pollution data in Toronto, Canada. Nonparametric smoothed representations of the association between mortality and air pollution were adequate to graphically distinguish between these two forms. Weighted nonlinear regression methods for relative risk models were adequate to give nearly unbiased estimates of threshold concentrations even under conditions of extreme exposure measurement error. The uncertainty in the threshold estimates increased with the degree of exposure error. Regression models incorporating threshold concentrations could be clearly distinguished from linear relative risk models in the presence of exposure measurement error. The assumption of a linear model given that a threshold model was the correct form usually resulted in overestimates in the number of averted premature deaths, except for low threshold concentrations and large measurement error.     

Parenting and children’s prosocial and problem behaviors in middle childhood: The role of Turkish mothers’ emotion socialization practices

Mechanisms by which the relations between different parenting behaviors and children’s prosocial and problem behaviors occur are the focus of the current study. Supportive and nonsupportive emotion socialization practices of mothers were considered as potential mediators. Further, the moderator role of gender was explored. Participants were 228 mothers of 6‐ to 11‐year‐old children living in Ankara, Turkey. Scales assessing parenting behaviors (specifically, positive parenting and inconsistent discipline), maternal reactions to children’s negative emotions, and prosocial and problem behaviors of children were completed by the mothers. The results revealed that supportive emotion socialization practices fully mediated the relation between positive parenting behaviors and both boys’ and girls’ prosocial behaviors. In contrast, nonsupportive emotion socialization practices partially mediated the relation between inconsistent parenting behaviors and problem behaviors, but only for girls. Findings indicated that girls were more vulnerable to their mothers’ inconsistent behaviors possibly because mother–daughter dyads are more likely to use emotion‐related language and to discuss emotions than mother–son dyads from a very early age.