Genetic Studies of Pathological Gambling: A Review of Methodology and Analyses of Data from the Vietnam Era Twin Registry

Twin studies represent an important and powerful approach to estimating the relative contributions of environmental and genetic factors to the expression of psychiatric illnesses. In this article, we first explain the rationale for using large populations of monozygotic and dizygotic twin pairs to estimate genetic and environmental contributions to a disorder and the statistical modeling associated with this approach. We then review results from studies of the Vietnam Era Twin Registry that use this methodology to examine the etiology of pathological gambling (PG) behaviors. The results provide strong evidence for genetic contributions to the development of PG in men and set the foundation for future studies aimed at identifying the manner in which specific genes and environmental factors individually and in conjunction contribute to PG.     

New directions for management accounting

Using a general systems rationale, this paper develops a theoretical structure for approaching the problem of management accounting. The management control problem is explicated in terms of maintaining a relationship between the enterprise's structure and its environment. An enterprise's structure is composed of three elements (and their inter-relations): a decision and control subsystem; a financial funds subsystem and an operating (physical transforms) subsystem. Portrayed in these terms, the problem of management accounting is shown to require a methodology which is able to take cognizance of economic, sociological, psychological and other aspects of the enterprise system. The model described here provides a general intellectual frame of reference for ordering the problem.     

Situational Factors Related to Childhood Sexual Abuse in the Orthodox Jewish Community Among Adult and Juvenile Offenders

In recent years, increasing attention has been paid to situational factors associated with childhood sexual abuse (CSA) to explain incidence of CSA, as well as to provide potential targets for prevention efforts. However, very few studies have examined situational factors associated with juvenile perpetration, despite juveniles composing a substantial proportion of offenders. In addition, no studies to our knowledge have applied a situational framework to CSA research in the Orthodox Jewish community (OJC). In the present study, we obtained data from therapists regarding 80 victims of CSA in the OJC from both the United States and Israel. We hypothesized that (a) more abusers’ first perpetration would be between ages 12 and 17 than between any other age range, which corresponds to increased sexual urges, as well as increased unsupervised access to minors; (b) among juvenile offenders, the time of day of the abuse would depend on the relationship of the offender to the victim; and (c) age of the victim and grooming strategies would be associated with the frequency of abuse. Our first two hypotheses were confirmed, and our third hypothesis was partially confirmed, as younger victims tended to have higher frequency of abuse. Additionally, we discuss possible implications of significant correlations found during exploratory analyses. Our results generally support the importance of considering culturally specific situational factors when studying or developing prevention efforts for CSA.     

Determination of the functional form of the relationship of covariates to the log hazard ratio in a Cox model

In this paper, we review available methods for determination of the functional form of the relation between a covariate and the log hazard ratio for a Cox model. We pay special attention to the detection of influential observations to the extent that they influence the estimated functional form of the relation between a covariate and the log hazard ratio. Our paper is motivated by a data set from a cohort study of lung cancer and silica exposure, where the nonlinear shape of the estimated log hazard ratio for silica exposure plotted against cumulative exposure and hereafter referred to as the exposure–response curve was greatly affected by whether or not two individuals with the highest exposures were included in the analysis. Formal influence diagnostics did not identify these two individuals but did identify the three highest exposed cases. Removal of these three cases resulted in a biologically plausible exposure–response curve.     

Researching social care for minority ethnic older people: implications of some Scottish research

Summary The paper explores issues raised by research on patterns ofwelfare and mutual care among older Pakistani people and theirfamilies, with particular reference to their use, or lack ofuse of social care services. Qualitative interviews were conductedwith (self-defined) minority ethnic older people, professionalsin statutory services and in minority-led community-based groups.The organization of services is discussed, with special referenceto issues of power and control, the role of the voluntary (non-profit)and statutory sectors, the debate regarding the possible needfor specialist versus generic services, and the role of minority-ledinitiatives. Secondly, issues of service staffing are examined,and the dangers of marginalizing minority services and staffreviewed, especially with reference to divisions of labour inservice provision and staff's own perspectives. Thirdly, themethodological implications of the work are explores, includingissues of linguistic and cultural communication and workingwith relatively powerless social groups, whose views are sought.Examining the views of professional social care workers is alsoproblematized, with reference to their gate-keeping role. Itis argued that user perspectives are essential to the developmentof appropriate services for minority ethnic groups. In conclusion,the need to raise these issues in other work is discussed.     

Stress Within Families: Some Questions and Possibilities

Individual children's capacity to cope with stressors may be predicated by the stress-coping mechanisms utilised by their families There appears to be a paucity of information about families' responses to stressors. It is postulated that there are significant questions about family coping mechanisms, and that research directed towards these questions may provide information of use in programmes which aim to facilitate the development of effective coping mechanisms in children. Assumptions about the delineation of coping mechanisms, the structure of family units, the designation of stressors., and the study of human behaviour are discussed. A brief outline is provided on a research project aimed at defining and analysing family coping behaviour, and at differentiating families that cope effectively with stressors from those that do not. Some initial impression of findings are presented.     

Hormone profiles,body mass index and aging male symptoms: results of the Androx Vienna Municipality study

Aging in the male is accompanied by steroid hormonal decline, and men may develop symptoms associated with hypogonadism. Increased awareness of ‘andropause’ in recent years has led to greater demand for hormonal assessments, resulting in a rising burden for health economics. We conducted a cross-sectional study to define men at risk for hypogonadism, in whom further hormonal investigation should be performed.

We examined 664 blue-collar workers aged 40–60 years at their workplace and determined hormonal status and body mass index (BMI). Men with an abnormal urogenital status and those on medication that might affect endocrine status were excluded from the study. All participants completed the validated Aging Male Symptom (AMS) questionnaire and obtained scores for psychological symptoms, somatovegetative symptoms, and sexual symptoms.

Multiple logistic regression analyses revealed a significantly increased risk (represented by the odds ratio) of psychological symptoms for men with low levels of testosterone and/or bioavailable testosterone (BAT). Increased BMI as well as low testosterone levels and/or low BAT levels raised the risk of somatovegetative symptoms. Each decrease of BAT by 1?ng/ml caused an approximately 1.8-fold increase of the risk (odds ratio?=?1.832, p?=?0.005). Additional independent risk factors were increased age and low luteinizing hormone (LH) level. Men aged 55 years with BMI >?28?kg/m² and with somatovegetative symptoms and moderate or severe psychological symptoms had a 7.2-fold increase in the risk of a BAT level <?1.5?ng/ml compared to men without these risk factors (p <?0.001). Sensitivity and specificity were 75% and 71%, respectively.

The AMS score combined with age and BMI provides an easy and convenient method to identify men with probable androgen deficiency who require hormonal assessment.     

Changes in incidence of sexual intercourse of unmarried teenagers following a community‐based sex education program

The nature and frequency of men's and women's sexual fantasies were investigated by surveying 307 students (182 females, 125 males) at a California state university or junior college via a paper‐and‐pencil questionnaire. The questionnnaire was inspired by modern evolutionary theory and was designed to investigate sex differences in sexual fantasies. Substantial sex differences were found in the salience of visual images, touching, context, personalization, emotion, partner variety, partner response, fantasizer response, and inward versus outward focus. These data, the scientific literature on sexual fantasy, the historically‐stable contrasts between male‐oriented pornography and female‐oriented romance novels, the ethnographic record of human sexuality, and the ineluctable implications of an evolutionary perspective on our species, taken together, imply the existence of profound sex differences in sexual psychologies.     

Regression calibration for logistic regression with multiple surrogates for one exposure

Methods have been developed by several authors to address the problem of bias in regression coefficients due to errors in exposure measurement. These approaches typically assume that there is one surrogate for each exposure. Occupational exposures are quite complex and are often described by characteristics of the workplace and the amount of time that one has worked in a particular area. In this setting, there are several surrogates which are used to define an individual's exposure. To analyze this type of data, regression calibration methodology is extended to adjust the estimates of exposure-response associations for the bias and additional uncertainty due to exposure measurement error from multiple surrogates. The health outcome is assumed to be binary and related to the quantitative measure of exposure by a logistic link function. The model for the conditional mean of the quantitative exposure measurement in relation to job characteristics is assumed to be linear. This approach is applied to a cross-sectional epidemiologic study of lung function in relation to metal working fluid exposure and the corresponding exposure assessment study with quantitative measurements from personal monitors. A simulation study investigates the performance of the proposed estimator for various values of the baseline prevalence of disease, exposure effect and measurement error variance. The efficiency of the proposed estimator relative to the one proposed by Carroll et al. [1995. Measurement Error in Nonlinear Models. Chapman & Hall, New York] is evaluated numerically for the motivating example. User-friendly and fully documented Splus and SAS routines implementing these methods are available (http://www.hsph.harvard.edu/faculty/spiegelman/multsurr.html).     

An economic model of teenage pregnancy decision-making

In this paper, we model unmarried teenagers' decisions about their pregnancy outcome by considering that the teenager contrasts her expected utility (1) as a married mother, (2) as an unmarried mother, or (3) after abortion. We use cross-sectional data on 297 California teenagers aged 13-19 who were pregnant for the first time between 1972 and 1974. Both Anglo and Mexican-American girls are included. We find that pregnant girls who are eligible for or are receiving public assistance are more likely to give birth and remain unmarried. Teenagers with greater time values are more likely to choose abortion, and Mexican-American girls are more likely to carry their pregnancies to term.