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This paper proposes a new problem by integrating the job shop scheduling, the part feeding, and the automated storage and retrieval problems. These three problems are intertwined and the performance of each of these problems influences and is influenced by the performance of the other problems. We consider a manufacturing environment composed of a set of machines (production system) connected by a transport system and a storage/retrieval system. Jobs are retrieved from storage and delivered to a load/unload area (LU) by the automated storage retrieval system. Then they are transported to and between the machines where their operations are processed on by the transport system. Once all operations of a job are processed, the job is taken back to the LU and then returned to the storage cell. We propose a mixed-integer linear programming (MILP) model that can be solved to optimality for small-sized instances. We also propose a hybrid simulated annealing (HSA) algorithm to find good quality solutions for larger instances. The HSA incorporates a late acceptance hill-climbing algorithm and a multistart strategy to promote both intensification and exploration while decreasing computational requirements. To compute the optimality gap of the HSA solutions, we derive a very fast lower bounding procedure. Computational experiments are conducted on two sets of instances that we also propose. The computational results show the effectiveness of the MILP on small-sized instances as well as the effectiveness, efficiency, and robustness of the HSA on medium and large-sized instances. Furthermore, the computational experiments clearly shown that importance of optimizing the three problems simultaneous. Finally, the importance and relevance of including the storage/retrieval activities are empirically demonstrated as ignoring them leads to wrong and misleading results.

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This article proposes a Bayesian computing algorithm to infer Gaussian directed acyclic graphs (DAGs). It has the ability of escaping local modes and maintaining adequate computing speed compared to existing methods. Simulations demonstrated that the proposed algorithm has low false positives and false negatives in comparison to an algorithm applied to DAGs. We applied the algorithm to an epigenetic dataset to infer DAG's for smokers and nonsmokers.  相似文献   
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